Imaging and speciation of trace elements in biological environment

Biochimie

Volumn 88, Issue 11, 2006, Pages 1591-1604

  Lobinski, R ^a   Moulin, C ^b   Ortega, R ^c  

^a Laboratoire de Chimie Analytique Bio Inorganique et Environnement UMR 5034   (France)

^b DANS   (France)

^c CENTRE D ETUDES NUCLÉAIRES DE BORDEAUX GRADIGNAN   (France)

Author keywords

Bioinorganic; Chemical imaging; Metallogenomics; Metallomics; Metalloproteomics; Speciation

Indexed keywords

TRACE ELEMENT; PROTEOME;

ANION EXCHANGE; ARTICLE; ATOMIC EMISSION SPECTROMETRY; BIOLOGICAL MONITORING; CAPILLARY ELECTROCHROMATOGRAPHY; CHROMATOGRAPHY; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENE SEQUENCE; GENOME; HUMAN; ION CYCLOTRON RESONANCE MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MICROANALYSIS; NONHUMAN; OXIDATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEOMICS; QUANTITATIVE ANALYSIS; SENSITIVITY ANALYSIS; SYNCHROTRON RADIATION; TISSUE SECTION; X RAY FLUORESCENCE; FOOD; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; POLLUTION; REVIEW; SENSITIVITY AND SPECIFICITY;

ENVIRONMENTAL POLLUTION; FOOD; MAGNETIC RESONANCE SPECTROSCOPY; PROTEOME; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TRACE ELEMENTS;

EID: 33751205918     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2006.10.003     Document Type: Article

References (124)

1. Guerinot M.L., and Salt D.E. Fortified foods and phytoremediation. Two sides of the same coin. Plant Physiol. 125 (2001) 164-167
2. Lahner B., Gong J., Mahmoudian M., Smith E.L., Abid K.B., Rogers E.E., Guerinot M.L., Harper J.F., Ward J.M., McIntyre L., Schroeder J.I., and Salt D.E. Genomic scale profiling of nutrient and trace elements in Arabidopsis thaliana. Nat. Biotechnol. 21 (2003) 1215-1221
3. Szpunar J. Advances in analytical methodology for bioinorganic speciation analysis: metallomics, metalloproteomics and heteroatom-tagged proteomics and metabolomics. Analyst 130 (2005) 442-465
4. Lobinski R., Schaumloffel D., and Szpunar J. Mass spectrometry in bioinorganic analytical chemistry. Mass Spectrom. Rev. 25 (2005) 255-289
5. Eide D.J., Clark S., Nair T.M., Gehl M., Gribskov M., Guerinot M.L., and Harper J.F. Characterization of the yeast ionome: a genome-wide analysis of nutrient mineral and trace element homeostasis in Saccharomyces cerevisiae. Genome Biol. 6 (2005) R77
6. Ortega R. Chemical elements distribution in cells. Nucl. Instrum. Methods. B231 (2005) 218-223
7. Goldstein J.I., Newburry D.E., Echlin P., Joy D.C., Romig Jr. A.D., Lyman C.E., Fiori C., and Lifshin E. Scanning Electron Microscopy and X-ray Microanalysis. A Text for Biologists, Materials Scientists, and Geologists (1992), Plenum Press, New York
8. Nott J.A. In: Siegee D.C., Morgan A.J., Summer A.T., and Warley A. (Eds). X-ray Microanalysis in Biology. Experimental Techniques and Applications (1993), Cambridge University Press, Cambridge
9. Zierold K. Heavy metal cytotoxicity studied by electron probe X-ray microanalysis of cultured hepatocytes. Toxicol. In Vitro 14 (2000) 557-563
10. Roomans G.M. Application of X-ray microanalysis to the study of cell physiology in cells attached to biomaterials. Eur. Cells Mat. 3 (2002) 1-8
11. Laquerriere P., Michel J., Balossier G., and Chénais B. Light element quantification in stimulated cells cryosections studied by electron probe microanalysis. Micron 33 (2002) 597-603
12. Llabador Y., and Moretto P. Applications of Nuclear Microprobes in the Life Sciences (1998), World Scientific, Singapore
13. Watt F., and Grime G.W. Particle Induced X-ray Emission Spectrometry (1995), John Wiley & Sons, New York
14. Devès G., Bouhacina T., and Ortega R. STIM mass measurements for quantitative trace element analysis within biological samples and validation using AFM thickness measurements. Spectrochimica Acta B 59 (2004) 1733-1738
15. Ortega R., Moretto P., Fajac A., Bénard J., Llabador Y., and Simonoff M. Quantitative mapping of platinum and essential trace metal in cisplatin resistant and sensitive human ovarian adenocarcinoma cells. Cell. Mol. Biol. 42 (1996) 77-88
16. Ortega R. Intracellular distributions of the anthracycline 4′-iodo-4′-deoxy-doxorubicin and essential trace metals using nuclear microprobe analysis. Polycyclic Aromatic Compd. 21 (2000) 99-108
17. Ortega R., Suda A., and Devès G. Nuclear microprobe imaging of gallium nitrate in cancer cells. Nucl. Instr. Methods. B 210 (2003) 364-367
18. Bertsch P.M., and Hunter D.B. Applications of synchrotron-based X-ray microprobes. Chem. Rev. 101 (2001) 1809-1842
19. Ortega R., Bohic S., Tucoulou R., Somogyi A., and Devès G. Micro-chemical element imaging of yeast and human cells using synchrotron X-ray microprobe with Kirkpatrick-Baez optics. Anal. Chem. 76 (2004) 309-314
20. 2-oligonucleotide nanocomposites. Nat. Mater. 2 (2003) 343
21. Twining B.S., Baines S.B., Fisher N.S., Maser J., Vogt S., Jacobsen C., Tovar-Sanchez A., and Sanudo-Wilhemy S. Quantifying trace elements un individual aquatic protest cells with a synchrotron X-ray fluorescence microprobe. Anal. Chem. 75 (2003) 3806-3816
22. Yang L., McRae R., Henary M.M., Patel R., Lai B., Vogt S., and Fahrni C. Imaging of the intracellular topography of copper with a fluorescent sensor and by synchrotron X-ray fluorescence microscopy. Proc. Natl. Acad. Sci. USA 102 (2005) 11179-11184
23. Pacholski M.L., and Winograd N. Imaging with mass spectrometry. Chem. Rev. 99 (1999) 2977-3005
24. Guerquin-Kern J.L., Wu T.D., Quintana C., and Croisy A. Progress in analytical imaging of the cell by dynamic secondary ion mass spectrometry. Biochim. Biophys. Acta 1724 (2005) 228-238
25. Chandra S., Smith D.R., and Morrison G.H. Subcellular imaging by dynamic SIMS ion microscopy. Anal. Chem. 72 (2000) A104-A114
26. Strick R., Strissel P.L., Gavrilov K., and Levi-Setti R. Cation-chromatin binding as shown by ion microscopy is essential for the structural integrity of chromosomes. J. Cell Biol. 155 (2001) 899-910
27. Guerquin-Kern J.L., Hillion F., Madelmont J.C., Labarre P., Papon J., and Croisy A. Ultra-structural cell distribution of the melanoma marker iodobenzamide: improved potentiality of SIMS imaging in life sciences. BioMedical Engeenering 3 (2004) 10-17
28. Galle P., Levi-Setti R., Lamperti A., Bourahla K., and Escaig F. Subcellular localization of aluminum and indium in the rat kidney. Appl. Surf. Sci. 231-232 (2004) 475-478
29. Chandra S., Lorey D.R., and Smith D.R. Quantitative subcellular secondary ion mass spectrometry (SIMS) imaging of boron-10 and boron-11 isotopes in the same cell delivered two combined BNCT drugs: in vitro studies on human glioblastoma T98G cells. Radiat. Res. 157 (2002) 700-710
30. Becker J.S., Zoriy M.V., Dehnhardt M., Pickhardt C., and Zilles K. Copper, zinc, phosphorous and sulfur distribution in thin section of rat brain tissues measured by LA-ICP MS: possibility for small-size tumor analysis. J. Anal. At. Spectrom. 20 (2005) 912-917
31. Kindness A., Sekaran C.N., and Feldmann J. Two-dimensional mapping of copper and zinc in liver sections by laser ablation-inductively coupled plasma mass spectrometry. Clin. Chem. 49 (2003) 1916-1923
32. Becker J.S., Zoriy M.V., Pickhardt C., Palomero-Gallagher N., and Zilles K. Imaging of copper, zinc, and other elements in thin section of human brain samples (hippocampus) by laser ablation inductively coupled plasma mass spectrometry. Anal. Chem. 77 (2005) 3208-3216
33. Pickhardt C., Brenner I.B., Becker J.S., and Dietze H.J. Determination of trace elements in zeolites by laser ablation ICP-MS. Fresenius J. Anal. Chem. 368 (2000) 79-87
34. Becker J.S., Gorbunoff A., Zoriy M., Izmer A., and Kayser M. Evidence of near-field laser ablation inductively coupled plasma mass spectrometry (NF-LA-ICP-MS) at nanometre scale for elemental and isotopic analysis on gels and biological samples. J. Anal. Atom. Spectrom. 21 (2006) 19-25
35. Becker J.S., Zoriy M., Przybylski M., and Becker J.S. Investigation of Cu-, Zn- and Fe-containing human brain proteins using isotopic-enriched tracers by LA-ICP-MS and MALDI-FT-ICR-Ms. Int. J. Mass Spectrom. 242 (2005) 135-144
36. Becker J.S., Boulyga S.F., Pickhardt C., Becker J., Buddrus S., and Przybylski M. Determination of phosphorus in small amounts of protein samples by ICP-MS. Anal. Bioanal. Chem. 375 (2003) 561-566
37. Becker J.S., Zoriy M., Becker J.S., Pickhardt C., and Przybylski M. Determination of phosphorous and metals in human brain proteins after isolation by GE by LA-ICP MS. J. Anal. At. Spectrom. 19 (2004) 149-152
38. J.L. Fleche, C. Moulin. Ab initio modeling of the interaction between Eu and DTPA. Chem. Eur. J. in press.
39. Moulin C., Amekraz B., Steiner V., Plancque G., and Ansoborlo E. Speciation studies on DTPA using the complementary nature of electrospray ionization mass spectrometry and time-resolved laser-induced fluorescence. Appl. Spectrosc. 57 (2003) 1151-1161
40. Ross A.R.S., Ikonomou M.G., Orians K.J., and Thompson J.J.A. Determination of dissolved metal species by electrospray ionization mass spectrometry. Anal. Chem. 70 (1998) 2225-2235
41. Harris W.R., Wang Z., and Hamada Z.H. Competition between transferrin and the serum ligands citrate and phosphate for the binding of aluminum. Inorg. Chem. 42 (2003) 3262-3273
42. Urvoas A., Amekraz B., Moulin C., Le Clainche L., Stocklin R., and Moutiez M. Analysis of the metal binding selectivity of the metallochaperone CopZ from Enterococcus hirae by electrospray ionization mass spectrometry. Rapid Commun. Mass Spectrom. 17 (2003) 1889-1896
43. Gao H., Yu Y., and Leary A.L. Mechanisms and kinetics of metalloenzyme phosphomannose isomerase: measurement of dissociation constant and effect of zinc binding using ESI-FTICR mass spectrometry. Anal. Chem. 77 (2005) 5596-5603
44. Bergquist J., Palmblad M., Wetterhall M., Hakansson P., and Markides E. Peptide mapping of proteins in human body fluids using electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry. Mass Spectrom. Rev. 21 (2002) 2-15
45. Klostermeier D., and Millar P.D. Time resolved fluorescence resonance energy transfer: a versatile tool for the analysis of nucleic acids. Biopolymers 61 (2001) 159-179
46. Rubino F.M., Verduci C., Giampiccolo R., Pulvirenti S., Brambilla G., and Colombi A. Characterization of the disulfides of bio-thiols by electrospray ionization and triple-quadrupole tandem mass spectrometry. J. Mass Spectrom. 39 (2004) 1408-1416
47. Szpunar J. Bioinorganic speciation analysis by hyphenated techniques. Analyst 125 (2000) 963-988
48. Wang J., Houk R.S., Dreessen D., and Wiederin D.R. Speciation of trace elements in proteins in human and bovine serum by size exclusion chromatography and inductively coupled plasma-mass spectrometry with a magnetic sector mass spectrometer. J. Biol. Inorg. Chem. 4 (1999) 546-553
49. Wang J., Dreessen D., Wiederin D.R., and Houk R.S. Measurement of trace elements in proteins extracted from liver by size exclusion chromatography-inductively coupled plasma-mass spectrometry with a magnetic sector mass spectrometer. Anal. Biochem. 288 (2001) 89-96
50. Rivero Martino F.A., Fernandez Sanchez M.L., and Sanz-Medel A. The potential of double focusing-ICP-MS for studying elemental distribution patterns in whole milk, skimmed milk and milk whey of different milks. Anal. Chim. Acta 442 (2001) 191-200
51. Ferrarello C.N., Fernandez de la Campa M.R., Sariego Muniz C., and Sanz-Medel A. Metal distribution patterns in the mussel mytilus edulis cytosols using size-exclusion chromatography and double focusing ICP-MS detection. Analyst 125 (2000) 2223-2229
52. Boulyga S.F., Loreti V., Bettmer J., and Heumann K.G. Application of SEC-ICP-MS for comparative analyses of metal-containing species in cancerous and healthy human thyroid samples. Anal. Bioanal. Chem. 380 (2004) 198-203
53. Goenaga Infante H., Van Campenhout K., Blust R., and Adams F.C. Inductively coupled plasma time-of-flight mass spectrometry coupled to high-performance liquid chromatography for multi-elemental speciation analysis of metalloproteins in carp cytosols. J. Anal. At. Spectrom. 17 (2002) 79-87
54. Ferrarello C.N., Fernandez de la Campa M.R., and Sanz-Medel A. Multielement trace-element speciation in metal-biomolecules by chromatography coupled with ICP-MS. Anal. Bioanal. Chem. 373 (2002) 412-421
55. Richarz A.N., and Bratter P. Speciation analysis of trace elements in the brains of individuals with Alzheimer's disease with special emphasis on metallothioneins. Anal. Bioanal. Chem. 372 (2002) 412-417
56. Richarz A.N., Wolf C., and Bratter P. Determination of protein-bound trace elements in human cell cytosols of different organs and different pathological states. Analyst 128 (2003) 640-645
57. Mason A.Z., and Borja M.R. A study of Cu turnover in proteins of the visceral complex of littorina littorea by stable isotopic analysis using coupled HPLC-ICP-MS. Mar. Environ. Res. 54 (2002) 351-355
58. Rodriguez-Cea A., Fernandez de la Campa M.R., Blanco Gonzalez E., Andon Fernandez B., and Sanz-Medel A. Metal speciation analysis in eel metallothioneins by anionic exchange-FPLC-isotope dilution-ICP-MS. J. Anal. At. Spectrom. 18 (2003) 1357-1364
59. De Smet H., De Wachter B., Lobinski R., and Blust R. Dynamics of (Cd,Zn)-metallothioneins in gills, liver and kidney of common carp Cyprinus carpio during cadmium exposure. Aquat. Toxicol. 52 (2001) 269-281
60. Mounicou S., Szpunar J., Andrey D., Blake C., and Lobinski R. Development of a sequential enzymolysis approach for the evaluation of the bioaccessibility of Cd and Pb from cocoa. Analyst 127 (2002) 1638-1641
61. Mounicou S., Szpunar J., Andrey D., Blake C., and Lobinski R. Bioavailability of cadmium and lead in cocoa: comparison of extraction procedures prior to size-exclusion fast-flow liquid chromatography with inductively coupled plasma mass spectrometric detection (SEC-ICP-MS). J. Anal. At. Spectrom. 17 (2002) 880-886
62. Mounicou S., Szpunar J., Andrey D., Blake C., and Lobinski R. Concentrations and bioavailability of cadmium and lead in cocoa powder and related products. Food Addit. Contam. 20 (2003) 343-352
63. Ferrarello C.N., Fernandez de la Campa M.R., Carrasco J.F., and Sanz-Medel A. Speciation of metallothionein-like proteins of the mussel Mytilus edulis at basal levels by chromatographic separations coupled to quadrupole and double-focusing magnetic sector ICP MS. Anal. Chem. 72 (2000) 5874-5880
64. Van Campenhout K., Goenaga Infante H., Adams F., and Blust R. Induction and binding of Cd, Cu, and Zn to metallothionein in carp (Cyprinus carpio) using HPLC-ICP-TOFMS. Toxicol. Sci. 80 (2004) 276-287
65. Bouyssiere B., Knispel T., Ruhnau C., Denkhaus E., and Prange A. Analysis of nickel species in cytosols of normal and malignant human colonic tissues using two dimensional liquid chromatography with ICP-sector field MS detection. J. Anal. At. Spectrom. 19 (2004) 196-200
66. Polec K., Perez-Calvo M., Garcia-Arribas O., Szpunar J., Ribas-Ozonas B., and Lobinski R. Investigation of metal complexes with metallothionein in rat tissues by hyphenated techniques. J. Inorg. Biochem. 88 (2002) 197-206
67. Giusti P., Schaumlöffel D., Preud'homme H., Szpunar J., and Lobinski R. Selenopeptide mapping in a selenium-yeast protein digest by the parallel nanoHPLC-ICPMS and nanoHPLC-electrospray MS/MS after on-line preconcentration. J. Anal. At. Spectrom. 21 (2006) 26-32
68. Kannamkumarath S.S., Wrobel K., B'Hymer C., and Caruso J.A. Capillary electrophoresis-inductively coupled plasma-mass spectrometry: an attractive complementary technique for elemental speciation analysis. J. Chromatogr. A 975 (2002) 245-266
69. Schaumlöffel D. Capillary liquid separation techniques with ICP MS detection. Anal. Bioanal. Chem. 379 (2004) 351-354
70. Yeh C.F., and Jiang S.J. Determination of monophosphate nucleotides by capillary electrophoresis inductively coupled plasma mass spectrometry. Analyst 127 (2002) 1324-1327
71. Profrock D., Leonhard P., Ruck W., and Prange A. Development and characterisation of a new interface for coupling capillary LC with collision-cell ICP-MS and its application for phosphorylation profiling of tryptic protein digests. Anal. Bioanal. Chem. 381 (2005) 194-204
72. Song Q.J., Greenway G.M., and McCreedy T. Interfacing a microfluidic electrophoresis chip with ICP MS for rapid elemental speciation. J. Anal. At. Spectrom. 19 (2004) 883-887
73. Prange A., Schaumloffel D., Bratter P., Richarz A.N., and Wolf C. Species analysis of metallothionein isoforms in human brain cytosols by use of capillary electrophoresis hyphenated to inductively coupled plasma-sector field mass spectrometry. Fresenius J. Anal. Chem. 371 (2001) 764-774
74. Profrock D., Leonhard P., and Prange A. Determination of sulfur and selected trace elements in metallothionein-like proteins using capillary electrophoresis hyphenated to inductively coupled plasma mass spectrometry with an octopole reaction cell. Anal. Bioanal. Chem. 377 (2003) 132-139
75. Polec-Pawlak K., Schaumlöffel D., Szpunar J., Prange A., and Lobinski R. Analysis for metal complexes with metallothionein in rat liver by capillary zone electrophoresis using ICP double-focussing sector-field isotope dilution MS and electrospray MS detection. J. Anal. At. Spectrom. 17 (2002) 908-912
76. Schaumloffel D., Prange A., Marx G., Heumann K.G., and Bratter P. Characterization and quantification of metallothionein isoforms by capillary electrophoresis-inductively coupled plasma-isotope-dilution mass spectrometry. Anal. Bioanal. Chem. 372 (2002) 155-163
77. Polec K., Szpunar J., Palacios O., Gonzalez-Duarte P., Atrian S., and Lobinski R. Investigation of metal binding by recombinant and native metallothioneins by capillary zone electrophoresis (CZE) coupled with inductively coupled plasma mass spectrometry (ICP MS) via a self-aspirating total consumption micronebulizer. J. Anal. At. Spectrom. 16 (2001) 567-574
78. Wang Z., and Prange A. Use of surface-modified capillaries in the separation and characterization of metallothionein isoforms by capillary electrophoresis inductively coupled plasma mass spectrometry. Anal. Chem. 74 (2002) 626-631
79. Timerbaev A.R., Aleksenko S.S., Polec-Pawlak K., Ruzik R., Semenova O., Hartinger C.G., Oszwaldowski S., Galanski M., Jarosz M., and Keppler B.K. Platinum metallodrug-protein binding studies by capillary electrophoresis-inductively coupled plasma-mass spectrometry: characterization of interactions between Pt(II) complexes and human serum albumin. Electrophoresis 25 (2004) 1988-1995
80. Van Lierde V., Strijckmans K., Galleni M., Devreese B., Van Beeumen J., Vanhaecke F., and Moens L. CE-ICP-SF MS for the detection of S and Zn in aeromonas hydrophila Zn-beta-lactamase, LC-GC Europe September (2003) 617-622
81. Van Lierde V., Chéry C.C., Strijckmans K., Galleni M., Devreese B., Van Beeumen J., Moens L., and Vanhaecke F. Capillary electrophoresis hyphenated to inductively coupled plasma-sector field-mass spectrometry for the stoichiometric determination of Zn bound to aeromonas hydrophila Zn beta-lactamase. J. Anal. At. Spectrom. 19 (2004) 888-893
82. Hagege A., Baldinger T., Martin-Jouet M., Zal F., Leroy M., Leize E., and Dorsselaer A.V. Assessment of the contribution of inductively coupled plasma mass spectrometry to metalloprotein analysis: a novel approach for studies of multiproteic complexes. Rapid Commun. Mass Spectrom. 18 (2004) 735-738
83. Lavorante A.F., Gine M.F., Gervasio A.P., Miranda C.E., Fiore M.F., Bellato C.M., and Carrilho E. Identification of a metallothionein in synechococcus by capillary electrophoresis hyphenated with inductively coupled plasma mass spectrometry. Anal. Sci. 19 (2003) 1611-1616
84. Alvarez-Llamas G., and Fernandez de la Campa M.R. Metallothionein isoforms separation and Cd speciation by capillary electrophoresis with UV and quadrupole-ICP MS detection. Anal. Chim. Acta 448 (2001) 105-119
85. Wolf C., Schaumloffel D., Richarz A.N., Prange A., and Bratter P. Cze-ICP-MS separation of metallothioneins in human brain cytosols: comparability of electropherograms obtained from different sample matrices. Analyst 128 (2003) 576-580
86. Schaumlöffel D., Ouerdane L., Bouyssiere B., and Lobinski R. Speciation analysis of nickel in the latex of a hyperaccumulating tree Sebertia acuminata by HPLC and CZE with ICP MS and electrospray MS-MS detection. J. Anal. At. Spectrom. 18 (2003) 120-127
87. Mounicou S., Polec K., Chassaigne H., Potin-Gautier M., and Lobinski R. Characterization of metal complexes with metallothioneins by CZE with ICP and ES MS detection. J. Anal. At. Spectrom. 15 (2000) 635-642
88. Polec K., Mounicou S., Chassaigne H., and Lobinski R. Probing metal-complexes with metallothioneins by reversed phase microbore chromatography and capillary zone electrophoresis coupled with inductively coupled plasma and electrospray mass spectrometry. Cell. Mol. Biol. 46 (2000) 221-235
89. Mounicou S., Vacchina V., Szpunar J., Potin-Gautier M., and Lobinski R. Determination of phytochelatins by capillary zone electrophoresis with electrospray tandem mass spectrometry detection (CZE-ES MS/MS). Analyst 126 (2001) 624-632
90. Gao Y.X., Chen C.Y., Zhang P.Q., Chai Z.F., He W., and Huang Y.Y. Detection of metalloproteins in human liver cytosol by synchrotron radiation X-ray fluorescence after sodium dodecyl sulphate polyacrylamide gel electrophoresis. Anal. Chim. Acta 485 (2003) 131-137
91. Weseloh G., Kühbacher M., Bertelsmann H., Özaslan M., Kyriakopoulos A., Knöchel A., and Behne D. Analysis of metal-containing proteins by gel electrophoresis and synchrotron radiation X-ray fluorescence. J. Radioanal. Nucl. Chem. 259 (2004) 473-477
92. Verbi F.M., Arruda S.C., Rodriguez A.P., Perez C.A., and Arruda M.A. Metal-binding proteins scanning and determination by combining gel electrophoresis, synchrotron radiation X-ray fluorescence and atomic spectrometry. J. Biochem. Biophys. Methods 62 (2005) 97-109
93. Bertrand M., Weber G., and Schoefs B. Metal determination and quantification in biological material using particle-induced X-ray emission. Trens Anal. Chem. 22 (2003) 254-262
94. Neilsen J.L., Abildtrup A., Christensen J., Watson P., Cox A., and McLeod C.W. Laser ablation inductively coupled plasma-mass spectrometry in combination with gel electrophoresis: a new strategy for speciation of metal binding serum proteins. Spectrochimica Acta B 53 (1998) 339-345
95. Ma R.L., McLeod C.W., Tomlinson K., and Poole R.K. Speciation of protein-bound trace elements by gel electrophoresis and atomic spectrometry. Electrophoresis 25 (2004) 2469-2477
96. Chery C.C., Gunther D., Cornelis R., Vanhaecke F., and Moens L. Detection of metals in proteins by means of polyacrylamide gel electrophoresis and laser ablation-inductively coupled plasma-mass spectrometry: application to selenium. Electrophoresis 24 (2003) 3305-3313
97. Ballihaut G., Tastet L., Pecheyran C., Bouyssiere B., Donard O.F.X., Grimaud R., and Lobinski R. Biosynthesis, purification and analysis of selenomethionyl calmodulin by gel electrophoresis-laser ablation ICP MS and capillary HPLC-ICP MS peptide mapping following in-gel tryptic digestion. J. Anal. At. Spectrom. 20 (2005) 493-499
98. Fan T.W.M., Pruszkowski E., and Shuttleworth S. Speciation of selenoproteins in se-contaminated wildlife by gel electrophoresis and laser ablation-ICP-MS. J. Anal. At. Spectrom. 17 (2002) 1621-1623
99. Wind M., Feldmann I., Jakubowski N., and Lehmann W.D. Spotting and quantification of phosphoproteins purified by gel electrophoresis and laser ablation-element mass spectrometry with phosphorus-31 detection. Electrophoresis 24 (2003) 1276-1280
100. Becker J.S., Boulyga S., Becker J.S., Pickhardt C., Damoc E., and Przybylski M. Structural identification and quantification of protein phosphorylations after gel electrophoresis separation using Fourier transform ion cyclotron resonance mass spectrometry, and LA ICP MS. Int. J. Mass Spectrom. 228 (2003) 985-997
101. Binet M.R.B., Ma R.L., McLeod C.W., and Poole R.K. Detection and characterization of zinc- and cadmium-binding proteins in Escherichia coli by gel electrophoresis and laser ablation-inductively coupled plasma-mass spectrometry. Anal. Biochem. 318 (2003) 30-38
102. Allardyce C.S., Dyson P.J., Abou-Shakra F.R., Birtwistle H., and Coffey J. Inductively coupled plasma mass spectrometry to identify protein drug targets from whole cell systems. Chem. Commun. (2001) 2708-2709
103. Becker J.S., Zoriy M., Krause-Buchholz U., Becker J.S., Pickhardt C., Przybylski M., Pompe W., and Rödel G. In gel screening of phosphorus and copper, zinc and iron in proteins of yeast mitochondria by LA-ICP-MS and identification of phosphorylated protein structures by MALDI-FT-ICR-MS after separation with two-dimensional gel electrophoresis. J. Anal. Atom. Spectrom. 19 (2004) 1236-1243
104. Behne D., and Kyriakopoulos A. Mammalian selenium-containing proteins. Annu. Rev. Nutr. 21 (2001) 453-473
105. Egerton R.F. Electron Energy-Loss Spectroscopy in the Electron Microscope, second ed (1996), Plenum, New York
106. In: Reimer L. (Ed). Energy-Filtering Transmission Electron Microscopy, Springer, Berlin (1995)
107. Leapman R.D. Detecting single atoms of calcium and iron in biological structures by electron energy-loss spectrum imaging. J. Microsc. 210 (2003) 5-15
108. Grohovaz F., Bossi M., Pezzati R., Meldolesi J., and Torri Tarelli F. High resolution ultrastructural mapping of total calcium: electron spectroscopic imaging/electron energy loss spectroscopy analysis of a physically/chemically processed nerve-muscle preparation. Proc. Natl. Acad. Sci. USA 93 (1996) 4799-4803
109. Daulton T.L., Little B.J., Lowe K., and Jones-Meehan J. Electron energy loss spectroscopy techniques for the study of microbial chromium(VI) reduction. J. Microbiol. Methods 50 (2002) 39-54
110. Morello M., Canini A., Grilli Caiola M., Martorana P., Bernardi G., and Sancesario G. Manganese detected by electron spectroscopy imaging and electron energy loss spectroscopy in mitochondria of normal rat brain cells. J. Trace Microprobe Tech. 20 (2002) 481-491
111. Susini J., Joyeux D., and Polack F. X-ray microscopy, Proceedings of the Seventh International Conference on X-ray Microscopy, J. Physique IV, vol. 104 (2002)
112. Harris H.H., Levina A., Dillon C.T., Mulyani I., Lai B., Cai Z., and Lay P.A. Time-dependent uptake, distribution and biotransformation of chromium(VI) in individual and bulk human lung cells: application of synchrotron radiation techniques. J. Biol. Inorg. Chem. 10 (2005) 105-118
113. Ortega R., Fayard B., Salomé M., Devès G., and Susini J. Chromium oxidation state imaging in mammalian cells exposed in vitro to soluble or particulate chromate compounds. Chem. Res. Toxicol. 18 (2005) 1512-1519
114. Pickering I.J., Wright C., Bubner B., Ellis D., Persans M.W., Yu E.Y., George G.N., Prince R.C., and Salt D.E. Chemical form and distribution of selenium and sulfur in the selenium hyperaccumulator Astragalus bisulcatus. Plant Physiol. 131 (2003) 1460-1467
115. Giusti P., Lobinski R., Szpunar J., and Schaumlöffel D. Development of a nebulizer for a sheathless interfacing of nanoHPLC and ICP MS. Anal. Chem. 21 (2006) 26-32
116. Ascone I., Fourme R., Hasnain S., and Hodgson K. Metallogenomics and biological X-ray absorption spectroscopy. J. Synchrotron Radiat. 12 (2005) 1-3
117. Hasnain S.S. Synchrotron techniques for metalloproteins and human disease in post genome era. J. Synchrotron Radiat. 11 (2004) 7-11
118. Kryukov G.V., and Gladyshev V.N. The prokaryotic selenoproteome. EMBO Rep. 5 (2004) 538-543
119. Gladyshev V.N., Kryukov G.V., Fomenko D.E., and Hatfield D.L. Identification of trace element-containing proteins in genomic databases. Annu. Rev. Nutr. 24 (2004) 579-596
120. Zhang Y., Fomenko D.E., and Gladyshev V.N. The microbial selenoproteome of the Sargasso Sea. Genome Biol. 6 (2005) R37
121. Andreini C., Bertini I., and Rosato A. A hint to search for metalloproteins in gene banks. Bioinformatics 20 (2004) 1373-1380
122. Maret W. Exploring the zinc proteome. J. Anal. At. Spectrom. 19 (2004) 15-19
123. Bertini I., and Rosato A. Bioinorganic chemistry in the postgenomic era. Proc. Natl. Acad. Sci. USA 100 (2003) 3601-3604
124. Vacchina V., Mari S., Czernic P., Margues L., Pianelli K., Schaumloeffel D., Lebrun M., and Lobinski R. Speciation of nickel in a hyperaccumulating plant by HPLC-ICP MS and electrospray MS/MS assisted by cloning using yeast complementation. Anal. Chem. 75 (2003) 2740-2745