Kinetic parameters and recognition of thymidine analogues with varying functional groups by thymidine phosphorylase

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 7, 2008, Pages 3866-3870

  Hatano, Akihiko ^a   Harano, Aiko ^a   Takigawa, Yoshikatsu ^a   Naramoto, Yasuhiro ^a   Toda, Keisuke ^a   Nakagomi, Yuuichi ^a   Yamada, Hideyuki ^a  

^a SHIZUOKA INSTITUTE OF SCIENCE AND TECHNOLOGY   (Japan)

Author keywords

Kinetic parameters; Substrate recognition; Thymidine analogues; Thymidine phosphorylase

Indexed keywords

1 [[2 HYDROXY 1 (HYDROXYMETHYL)ETHOXY]METHYL]THYMINE; 2',3' DIDEOXYTHYMIDINE; 4' BETA THIOTHYMIDINE; 4' THIO 1' ALPHA THYMIDINE; 4' THIOTHYMIDINE; 5' DEOXYTHYMIDINE; AMINO ACID; AZATHYMIDINE; DEOXYCYTIDINE; FUNCTIONAL GROUP; HYDROXYL GROUP; PHOSPHATE; PYRIMIDINE NUCLEOSIDE; THYMIDINE; THYMIDINE DERIVATIVE; THYMIDINE PHOSPHORYLASE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; MOLECULAR RECOGNITION; POLARIZATION; REACTION ANALYSIS;

KINETICS; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; THYMIDINE; THYMIDINE PHOSPHORYLASE;

EID: 41649102610     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.01.038     Document Type: Article

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