Design and synthesis of novel diaryl heterocyclic derivatives as selective cyclooxygenase-2

Letters in Drug Design and Discovery

Volumn 5, Issue 2, 2008, Pages 127-133

  Li, S X ^a,b   Deng, X D ^b   Jiang, F L ^b   Zhao, Y J ^a   Xiao, W S ^b   Kuang, X Z ^b   Sun, X M ^b  

^a BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

^b JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Analgesic; Anti inflammatory; COX 2; NSAIDs; Potency; Synthesis

Indexed keywords

1 (3 FLUOROPHENYL) 5 [4 (METHYLSULFONYL)PHENYL] 3 (TRIFLUOROMETHYL) 1H PYRAZOLE; 2 FLUORO 4 (3 METHYL 5 PHENYL 1H PYRAZOL 1 YL)BENZENESULFONAMIDE; 2 FLUORO 4 [5 (4 METHOXYPHENYL) 3 (TRIFLUOROMETHYL) 1H PYRAZOL 1 YL]BENZENESULFONAMIDE; 2 FLUORO 4 [5 [3 FLUORO 4 (METHYLTHIO)PHENYL] 3 (TRIFLUOROMETHYL) 1H PYRAZOL 1 YL]BENZENESULFONAMIDE; 2 FLUORO 4 [5 [4 (METHYLTHIO)PHENYL] 3 (TRIFLUOROMETHYL) 1H PYRAZOL 1 YL]BENZENESULFONAMIDE; 2 FLUORO 4 [5 [4 (PYRROLIDIN 1 YL)PHENYL] 3 (TRIFLUOROMETHYL) 1H PYRAZOL 1 YL]BENZENESULFONAMIDE; 3 [4 (1H PYRROL 1 YL)PHENYL] 4 [3 FLUORO 4 (METHYLSULFONYL)PHENYL]FURAN 2(5H) ONE; 3 [4 (1H PYRROL 1 YL)PHENYL] 4 [4 (METHYLSULFONYL)PHENYL]FURAN 2(5H) ONE; 4 [3 FLUORO 4 (METHYLSULFONYL)PHENYL] 3 (THIOPHEN 3 YL)FURAN 2(5H) ONE; 4 [5 [3 FLUORO 4 (METHYLTHIO)PHENYL] 3 (TRIFLUOROMETHYL) 1H PYRAZOL 1 YL]BENZENESULFONAMIDE; 4 [5 [4 (1H PYRROL 1 YL)PHENYL] 3 (TRIFLUOROMETHYL) 1H PYRAZOL 1 YL] 2 FLUOROBENZENESULFONAMIDE; 4 [5 [4 (1H PYRROL 1 YL)PHENYL] 3 (TRIFLUOROMETHYL) 1H PYRAZOL 1 YL]BENZENESULFONAMIDE; CELECOXIB; CYCLOOXYGENASE 2 INHIBITOR; HETEROCYCLIC COMPOUND; ROFECOXIB; SULFONAMIDE; SULFONE DERIVATIVE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; EDEMA; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 41649091601     PISSN: 15701808     EISSN: None     Source Type: Journal    
DOI: 10.2174/157018008783928517     Document Type: Article

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