A topoisomerase II-dependent mechanism for resetting replicons at the S-M-phase transition

Genes and Development

Volumn 22, Issue 7, 2008, Pages 860-865

  Cuvier, Olivier ^a   Stanojcic, Slavica ^a   Lemaitre, Jean Marc ^a,b   Mechali, Marcel ^a  

^a INSTITUTE OF HUMAN GENETICS   (France)

^b INSTITUT DE GÉNOMIQUE FONCTIONNELLE   (France)

Author keywords

Checkpoint; DNA combing; DNA replication foci; DNA replication origins; ICRF; ORC

Indexed keywords

CAFFEINE; CELL PROTEIN; DNA TOPOISOMERASE (ATP HYDROLYSING); PROTEIN ORC1; PROTEIN ORC2; SINGLE STRANDED DNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CYCLE M PHASE; CELL CYCLE S PHASE; CHROMOSOME SEGREGATION; COMPLEX FORMATION; CONTROLLED STUDY; DNA REPLICATION; MITOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN STABILITY; REPLICON;

ANIMALS; CELL DIVISION; CHROMATIN ASSEMBLY AND DISASSEMBLY; CYCLIN-DEPENDENT KINASES; DNA TOPOISOMERASES, TYPE II; FEMALE; IMMUNOBLOTTING; MALE; MUTATION; OOCYTES; ORIGIN RECOGNITION COMPLEX; PURINES; REPLICON; S PHASE; XENOPUS; XENOPUS PROTEINS;

EID: 41649088278     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.445108     Document Type: Article

References (34)

1. Adachi, Y. and Laemmli, U.K. 1994. Study of the cell cycle-dependent assembly of the DNA pre-replication centres in Xenopus egg extracts. EMBO J. 13: 4153-4164.
2. Adachi, Y., Luke, M., and Laemmli, U.K. 1991. Chromosome assembly in vitro: Topoisomerase II is required for condensation. Cell 64: 137-148.
3. Andrews, C.A., Vas, A.C., Meier, B., Gimenez-Abian, J.F., Diaz-Martinez, L.A., Green, J., Erickson, S.L., Vanderwaal, K.E., Hsu, W.S., and Clarke, D.J. 2006. A mitotic topoisomerase II checkpoint in budding yeast is required for genome stability but acts independently of Pds1/securin. Genes & Dev. 20: 1162-1174.
4. Berezney, R., Dubey, D.D., and Huberman, J.A. 2000. Heterogeneity of eukaryotic replicons, replicon clusters, and replication foci. Chromosoma 108: 471-484.
5. Bernis, C., Vigneron, S., Burgess, A., Labbe, J.C., Fesquet, D., Castro, A., and Lorca, T. 2007. Pin1 stabilizes Emi1 during G2 phase by preventing its association with SCF(βtrcp). EMBO Rep. 8: 91-98.
6. Cuvier, O. and Hirano, T. 2003. A role of topoisomerase II in linking DNA replication to chromosome condensation. J. Cell Biol. 160: 645-655.
7. Cuvier, O., Lutzmann, M., and Mechali, M. 2006. ORC is necessary at the interphase to mitosis transition to recruit cdc2 kinase and disassemble RPA foci. Curr. Biol. 16: 516-523.
8. DePamphilis, M.L. 1997. The search for origins of DNA replication. Methods 13: 211-219.
9. DePamphilis, M.L. 2003. The 'ORC cycle': A novel pathway for regulating eukaryotic DNA replication. Gene 310: 1-15.
10. Di Fiore, B. and Pines, J. 2007. Emi1 is needed to couple DNA replication with mitosis but does not regulate activation of the mitotic APC/C. J. Cell Biol. 177: 425-437.
11. Françon, P., Lemaître, J.-M., Dryer, C., Maiorano, D., Cuvier, O., and Méchali, M. 2004. A hypophosphorylated form of RPA 34 is a specific component of pre-replication centers. J. Cell Sci. 117: 4909-4920.
12. Gavin, K.A., Hidaka, M., and Stillman, B. 1995. Conserved initiator proteins in eukaryotes. Science 270: 1667-1671.
13. Gilbert, D.M. 2001. Making sense of eukaryotic DNA replication origins. Science 294: 96-100.
14. Hirano, T. and Mitchison, T.J. 1993. Topoisomerase II does not play a scaffolding role in the organization of mitotic chromosomes assembled in Xenopus egg extracts. J. Cell Biol. 120: 601-612.
15. Kitamura, E., Blow, J.J., and Tanaka, T.U. 2006. Live-cell imaging reveals replication of individual replicons in eukaryotic replication factories. Cell 125: 1297-1308.
16. Lemaitre, J.M., Danis, E., Pasero, P., Vassetzky, Y., and Mechali, M. 2005. Mitotic remodeling of the replicon and chromosome structure. Cell 123: 787-801.
17. Li, C.J. and DePamphilis, M.L. 2002. Mammalian Orc1 protein is selectively released from chromatin and ubiquitinated during the S-to-M transition in the cell division cycle. Mol. Cell. Biol. 22: 105-116.
18. Losada, A., Hirano, M., and Hirano, T. 2002. Cohesin release is required for sister chromatid resolution, but not for condensin-mediated compaction, at the onset of mitosis. Genes & Dev. 16: 3004-3016.
19. Mechali, M. 2001. DNA replication origins: From sequence specificity to epigenetics. Nat. Rev. Genet. 2: 640-645.
20. Mendez, J., Zou-Yang, X.H., Kim, S.Y., Hidaka, M., Tansey, W.P., and Stillman, B. 2002. Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication. Mol. Cell 9: 481-491.
21. Michalet, X., Ekong, R., Fougerousse, F., Rousseaux, S., Schurra, C., Hornigold, N., van Slegtenhorst, M., Wolfe, J., Povey, S., Beckmann, J.S., et al. 1997. Dynamic molecular combing: Stretching the whole human genome for high-resolution studies. Science 277: 1518-1523.
22. Prasanth, S.G., Prasanth, K.V., and Stillman, B. 2002. Orc6 involved in DNA replication, chromosome segregation, and cytokinesis. Science 297: 1026-1031.
23. Prasanth, S.G., Prasanth, K.V., Siddiqui, K., Spector, D.L., and Stillman, B. 2004. Human Orc2 localizes to centrosomes, centromeres and heterochromatin during chromosome inheritance. EMBO J. 23: 2651-2663.
24. Reimann, J.D., Freed, E., Hsu, J.Y., Kramer, E.R., Peters, J.M., and Jackson, P.K. 2001. Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Cell 105: 645-655.
25. Romanowski, P., Madine, M.A., Rowles, A., Blow, J.J., and Laskey, R.A. 1996. The Xenopus origin recognition complex is essential for DNA replication and MCM binding to chromatin. Curr. Biol. 6: 1416-1425.
26. Saha, T., Ghosh, S., Vassilev, A., and DePamphilis, M.L. 2006. Ubiquitylation, phosphorylation and Orc2 modulate the subcellular location of Orc1 and prevent it from inducing apoptosis. J. Cell Sci. 119: 1371-1382.
27. Shechter, D., Costanzo, V., and Gautier, J. 2004. ATR and ATM regulate the timing of DNA replication origin firing. Nat. Cell Biol. 6: 648-655.
28. Solomon, M.J., Glotzer, M., Lee, T.H., Philippe, M., and Kirschner, M.W. 1990. Cyclin activation of p34cdc2. Cell 63: 1013-1024.
29. Takasuga, Y., Andoh, T., Yamashita, J., and Yagura, T. 1995. ICRF-193, an inhibitor of topoisomerase II, demonstrates that DNA replication in sperm nuclei reconstituted in Xenopus egg extracts does not require chromatin decondensation. Exp. Cell Res. 217: 378-384.
30. Tanabe, K., Ikegami, Y., Ishida, R., and Andoh, T. 1991. Inhibition of topoisomerase II by antitumor agents bis(2,6-dioxopiperadine) derivatives. Cancer Res. 51: 4903-4908.
31. Walter, J. and Newport, J.W. 1997. Regulation of replicon size in Xenopus egg extracts. Science 275: 993-995.
32. Wang, J.C. 2002. Cellular roles of DNA topoisomerases: A molecular perspective. Nat. Rev. Mol. Cell Biol. 3: 430-440.
33. Woodward, A.M., Gohler, T., Luciani, M.G., Oehlmann, M., Ge, X., Gartner, A., Jackson, D.A., and Blow, J.J. 2006. Excess Mcm2-7 license dormant origins of replication that can be used under conditions of replicative stress. J. Cell Biol. 173: 673-683.
34. Xu, Y.X. and Manley, J.L. 2007. The prolyl isomerase Pin1 functions in mitotic chromosome condensation. Mol. Cell 26: 287-300.