Biochemical characterization of the optic nerve in mice overexpressing the p53 gen. Oxidative stress assays;Caracterización bioquímica del nervio óptico en el ratón que sobreexpresa el gen p53. Análisis de estrés oxidativo

Archivos de la Sociedad Espanola de Oftalmologia

Volumn 83, Issue 2, 2008, Pages 105-111

  Gallego Pinazo, Roberto ^a,b   Zanon Moreno V ^c   Sanz, S ^c,d   Andres V ^c,d   Serrano, M ^d,e   Garcia Cao I ^d,e   Pinazo Duran M D ^b,e  

^a HOSPITAL UNIVERSITARIO LA FE   (Spain)

^b HOSPITAL UNIVERSITARIO DR PESET   (Spain)

^c INSTITUTO DE BIOMEDICINA DE VALENCIA   (Spain)

^d CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

^e HOSPITAL PUNTA DE EUROPA   (Spain)

Author keywords

Nitric oxide; Optic nerve; Oxidative stress; P53 gene; Super p53 mice

Indexed keywords

PROTEIN P53;

ANIMAL; ARTICLE; BIOSYNTHESIS; C57BL MOUSE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOUSE; OPTIC NERVE; OXIDATIVE STRESS; TUMOR SUPPRESSOR GENE;

ANIMALS; GENE EXPRESSION REGULATION; GENES, P53; MICE; MICE, INBRED C57BL; OPTIC NERVE; OXIDATIVE STRESS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 41549143856     PISSN: 03656691     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Muñoz A. Genes supresores de tumores y genes de reparación del DNA. Madrid: Editorial Hélice; 1997; 205-239.
2. Zavaglia D, Lin EH, Guidetti M, Pluquet O, Hianaut P, Favrot MC, et al. Poor intercellular transport and abscence of enhanced antiproliferative activity alter non-viral gene transfer of VP22-P53 or P53-VP22 fusions into p53 null cell lines in vitro or in vivo. J Gene Med 2005; 7: 936-944.
3. García-Cao I, Carcía-Cao M, Martín-Caballero J, Criado LK, Klatt P, Flores JM, et al. «Super p53» mice exhibit enhanced DNA damage response, are tumor resistant and age normally. EMBO J 2002; 21: 6225-6235.
4. Steller H. Mechanisms and genes of cellular suicide. Science 1995; 267: 1445-1449.
5. Odin L, Favrot M, Poujol D, Mitchot JP, Moingeon P, Tartaglia J, et al. Canarypox virus expressing wild type p53 for gene therapy in murine tumors mutated in p53. Cancer Gene Ther 2001; 8: 87-98.
6. Boultwood J. Ataxia telangiectasia gene mutations in leukaemia and lymphoma. J Clin Pathol 2001; 54: 512-516.
7. Bates S, Voudsen KH. P53 in signaling checkpoint arrest or apoptosis. Curr Opin Genet Dev 1996; 6: 12-18.
8. Lotem J, Peled-Kamar M, Groner Y, Sachs L. Cellular oxidative stress and the control of apoptosis by wild type p53, cytotoxic compounds and cytokines. Proctl Natl Acad Sci USA 1996; 93: 9166-9171.
9. Raff MC. Social controls on cell survival and cell death. Nature 1992; 356: 397-400.
10. Guo L, Moss SE, Alexander RA, Ali RR, Fitzke FW, Cordeiro MF. Retinal glanglion cell apoptosis in glaucoma is related to intraocular pressure and IOP-induced effects on extracellular matrix. Invest Ophthalmol Vis Sci 2005; 46: 175-182.
11. Kerrigan LA, Zack DJ, Quigley HA, Smith SD, Pease ME. TUNEL-positive ganglion cell in human primary open-angle glaucoma. Arch Ophthalmol 1997; 115: 1031-1035.
12. Wu LY, Hinton DR, Guo L, Jiang S, Wang JT, Zeng A, et al. Microphtalmia resulting from MSX2-induced apoptosis in the optic vesicle. Invest Ophthalmol Vis Sci 2003; 44: 2404-2412.
13. Strömland K, Pinazo-Duran MD. Optic nerve hypoplasia: comparative effects in children and rats exposed to alcohol during pregnancy. Teratology 1994; 50: 100-111.
14. Pinazo-Duran MD, Renau J, Guerri C, Strömland K. Optic nerve hypoplasia in fetal alcohol syndrome: an update. Eur J Ophthalmol 1997; 7: 262-270.
15. Strömland K, Pinazo-Duran MD. Ophthalmic involvement in the fetal alcohol syndrome: clinical and animal model studies. Alcohol Alcohol 2002; 37: 2-8.
16. Pinazo-Duran MD, Iborra JF, Pons S, Sevilla E, Gallego-Pinazo R, Muñoz A. Postnatal thyroid hormone supplementation rescues developmental abnormalities induced by congenital-neonatal hypothyroidism in the rat retina. Ophthalmic Res 2002; 37: 225-234.
17. Melo P, Rodrigues LG, Pinazo-Duran MD, Tavares MA. Methamphetamine and lipid peroxidation in the rat retina. Birth Defects Res A Clin Mol Teratol 2005; 73: 455-460.
18. Pinazo-Duran MD, Cervera R, Pons S, Zanon VC, Gallego-Pinazo R, Guerri C. Mecanismos de expresión proteica en el nervio óptico de la rata. Arch Soc Esp Oftalmol 2005; 80: 99-104.
19. Lowe SW, Bodis S, McClatchey, Remington L, Ruley HE, Fisher DE, et al. p53 status and the efficacy of cancer therapy in vivo. Science 1994; 266: 807-810.
20. Neufeld AH, Sawada A, Becker B. Inhibition of nitric oxide synthase 2 by aminoguanidine provides neuroprotection of retinal ganglion cells in a rat miodel of chronic glaucoma. Proctl Natl Acad Sci USA 1999; 96: 9944-9948.
21. Wang X, Zalcenstein A, Oren M. Nitric oxide promotes p53 nuclear retention and sensitizes neuroblastoma cells to apoptosis by ionizing radiation. Cell Death Differ 2003; 10: 468-476.
22. Forrester K, Ambs S, Lupold SE, Kapust RB, Spillare EA, Weinberg WC, et al. Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild type p53. Proctl Natl Acad Sci USA 1996; 93: 2442-2447.