Effect of folic acid in women with and without insulin resistance who have hyperhomocysteinemic polycystic ovary syndrome

International Journal of Gynecology and Obstetrics

Volumn 101, Issue 2, 2008, Pages 156-160

  Kazerooni, Talieh ^a   Asadi, Nasrin ^a   Dehbashi, Sedigheh ^a   Zolghadri, Jaleh ^a  

^a SHIRAZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Folic acid; Hyperhomocysteinemia; Insulin resistance; Polycystic ovary syndrome

Indexed keywords

FOLIC ACID; HOMOCYSTEINE;

ADOLESCENT; ADULT; ARTICLE; BLOOD ANALYSIS; BODY MASS; CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; FEMALE; HUMAN; HYPERHOMOCYSTEINEMIA; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL;

EID: 41549115875     PISSN: 00207292     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijgo.2007.10.024     Document Type: Article

References (24)

1. De la Calle M., Usandizga R., Sancha M., Magdaleon F., Herranz A., and Carillo E. Homocysteine, folic acid and B-group vitamins in obstetrics and gynecology. Eur J Obstet Gynecol Reprod Biol 107 (2003) 125-134
2. Villa P., Perr C., Suriano R., Cucinelli F., Panunzi S., Ranieri M., et al. Folic acid supplementation in healthy postmenopausal women: effect on homocysteine and glycolipid metabolism. J Clin Endocrinol Metab 90 (2005) 4622-4629
3. Meigs J.B., Jacques P.F., Selhub J., Singer D.E., Nathan D.M., Rifai N., et al. Fasting plasma homocysteine levels in the insulin resistance syndrome: the Framingham offspring study. Diabetes Care 24 (2001) 1403-1410
4. Fonseca V.A., Fink K.L., and Kern P.A. Insulin sensitivity and plasma homocysteine concentrations in nondiabetic obese and normal-weight subjects. Atherosclerosis 167 (2003) 105-109
5. Laivuori H., Kaaja R., Turpeinen V., Vinikka L., and Yli korkala D. Plasma homocysteine levels elevated and inversely related to insulin sensitivity in preeclampsia. Obstet Gynecol 93 (1999) 489-930
6. Audelin M.C., and Genest Jr. J. Homocysteine and cardiovascular disease in diabetes mellitus. Atherosclerosis 159 (2001) 497-511
7. Mcfarlane S.I., Banerji M., and Sowers J.R. Insulin resistance and cardiovascular disease. J Clin Endocrinol Metab 86 (2001) 713-718
8. Stout R.W. Insulin and atheroma: a 20-yr perspective [abstract]. Diabetes Care 13 (1990) 631-654
9. Gallisth S., Sudi K., Mangge H., Erwa W., and Borkenstein M. Insulin is an independent correlate of plasma homocysteine levels in obese children and adolescents. Diabetes Care 23 (2000) 1348-1352
10. Godsland I.F., Rosankiewicz J.R., Proudler A.J., and Johnston D.G. Plasma total homocysteine concentrations are unrelated to insulin sensitivity and components of the metabolic syndrome in healthy men. J Clin Endocrinol Metab 86 (2001) 719-723
11. Scarpitta A.M., and Sinagra D. Polycystic ovary syndrome: an endocrine and metabolic disease [abstract]. Gynecol Endocrinol 14 (2000) 392-395
12. Kely C.J., Speirs A., Gould G.W., Petvie J.R., Lyall H., and Kelly J.M. Altered vascular function in young women with polycystic ovary syndrome. J Clin Endocrinol Metab 87 (2002) 742-746
13. Lergo R.S., Kunselman A.R., and Dunaif A. Prevalence and predictors of dyslipedemia in women with polycystic ovary syndrome. Am J Med 111 (2001) 607-613
14. The Rotterdam ESHRE/ASRM-sponsored PCOS consensus work-shop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod 19 1 (2004) 41-47
15. Woo K.S., Chook P., Chan L.L., Cheung A.S., Fung W.H., Oiao M., et al. Long-term improvement in homocysteine levels and arterial endothelial function after one-year folic acid supplementation. Am J Med 112 (2002) 535-539
16. De Leo V., La Marea A., Morgante G., Ciani F., Zammarchi, and Steacci C. Low-dose folic acid supplementation reduces plasma levels of the cardiovascular risk factor homocysteine in postmenopausal women. Am J Obstet Gynecol 183 (2000) 945-947
17. Kilicdag E.B., Bagis T., Tarim E., Aslan E., Erkanli S., Simsek E., et al. Administration of B-group vitamins reduces circulating homocysteine in polycystic ovarian syndrome patients treated with metformin: a randomized trial. Hum reprod 20 (2005) 1521-1528
18. Hrnciar J., Gabor D., Hrn Ciarova M., Okapcova J., Szentivanyi M., and Kurray P. Relation between cytokines (TNF-alpha, IL-1 and 6) and homocysteine in android obesity and the phenomenon of insulin resistance syndrome. Vnitr Lek 45 (1999) 11-16
19. Giltay E.G., Hoogeveen E.K., Elbers J.M., Gooren L.J., Asscherman H., and Stehouwer C.D. Insulin resistance is associated with elevated plasma total homocysteine levels in healthy, nonobese subjects. Atherosclerosis 139 (2001) 197-198
20. Gori T., Buvotein J.M., Ahmed S., Miner S.E., Kelly S., Parker J.D., et al. Folic acid prevents nitroglycerin-induced nitric oxide synthase dysfunction and nitrate tolerance: a human in vivo study. Circulation 104 (2001) 119-123
21. Schachter M., Raziel A., Friedler S., Strassburger D., Bern O., and Ron-El R. Insulin resistance in patients with polycystic ovary syndrome with elevated plasma homocycsteine. Hum Reprod 18 (2003) 721-727
22. Abbasi F., Facchini F., Humphreys M.H., and Reaven G.M. Plasma homocysteine concentrations in healthy volunteers are not related to differences in insulin-mediated glucose disposal. Atherosclerosis 146 (1999) 175-178
23. Sills E.S., Genton M.G., Perloe M., Schattman G.L., Bralley J.A., and Tucker M.J. Plasma homocysteine, fasting insulin, and androgen patterns among women with polycystic ovaries and infertility. J Obstet Gynecol Res 27 (2001) 163-168
24. Badawy A., State O., El Gawad S.Sh., and El Aziz O.A. Plasma homocysteine and polycystic ovary syndrome: the missed link. Eur J Obstet Gynecol Reprod Biol 131 (2007) 68-72