L-folic acid supplementation in healthy postmenopausal women: Effect on homocysteine and glycolipid metabolism

Journal of Clinical Endocrinology and Metabolism

Volumn 90, Issue 8, 2005, Pages 4622-4629

  Villa, Paola ^a   Perri, Concetta ^a   Suriano, Rosanna ^a   Cucinelli, Francesco ^a   Panunzi, Simona ^b   Ranieri, Micaela ^a   Mele, Cristina ^a   Lanzone, Antonio ^a  

^a CATHOLIC UNIVERSITY   (Italy)

^b National Research Center   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; CYSTEINE; FOLIC ACID; GLUCOSE; GLYCINE; GLYCOLIPID; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HOMOCYSTEINE; INSULIN; LEVOFOLENE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; METHIONINE; PLACEBO;

ADULT; AMINO ACID METABOLISM; AREA UNDER THE CURVE; ARTICLE; ATHEROSCLEROSIS; CARBOHYDRATE METABOLISM; CHOLESTEROL BLOOD LEVEL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; FEMALE; GLUCOSE METABOLISM; GLYCEMIC INDEX; HUMAN; HYPERINSULINEMIA; INSULIN SENSITIVITY; LIPID METABOLISM; LIPOPROTEIN BLOOD LEVEL; LOADING TEST; NORMAL HUMAN; ORAL GLUCOSE TOLERANCE TEST; POSTMENOPAUSE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; SUPPLEMENTATION;

BLOOD GLUCOSE; CARDIOVASCULAR DISEASES; CHOLESTEROL, HDL; CHOLESTEROL, LDL; CYSTEINE; ENERGY METABOLISM; FEMALE; FOLIC ACID; HEMATINICS; HOMOCYSTEINE; HUMANS; HYPERHOMOCYSTEINEMIA; INSULIN; MIDDLE AGED; POSTMENOPAUSE; RISK FACTORS; RISK REDUCTION BEHAVIOR;

EID: 23844464791     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2004-1954     Document Type: Article

References (46)

1. Kluijtmans LA, Van den Heuvel LP, Boers GH, Frosst P, Stevens EM, Van Oost BA, Den Heijer M, Trijbels FJ, Rozen R, Blom HJ 1996 Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation in the methylentetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease. Am J Hum Genet 58:35-41
2. Selhub J, Jacques PF, Wilson PW, Rush D, Rosenberg IH 1993 Vitamin status and intake as primary determinants of homocysteinemia in the ederly. J Am JAMA 270:2693-2698
3. Van Der Gried R, Biesma DH, Haas FJLM, Faber JAJ, Duran M, Meuwissen OJATH, Banga JD 2000 The effect of different treatment regimens in reducing fasting and postmethionine-load homocysteine concentrations. J Int Med 248:223-229
4. Scott JM 2000 Homocysteine and cardiovascular risk. Am J Clin Nutr 72:333-334
5. Pfanzagl B, Tribl F, Koller E, Moslinger T 2003 Homocysteine strongly enhances metal-catalyzed LDL oxidation in the presence of cysteine. Atherosclerosis 168:39-48
6. Dudman NPB, Wilcken DEL, Stocker R 1993 Circulating lipid hydroperoxide levels in human hyperhomocysteinemia: relevance to development of atherosclerosis. Arterioscl Thromb 13:512-516
7. Saez G, Thornalley PJ, Hill HA, Herms R, Bannister JV 1982 The production of free radicals during the autooxidation of cysteine and their effect on isolated rat hepatocytes. Biochim Biophys Acta 719:24-31
8. Hellsten Y, Svensson M, Sjodin B, Smith S, Christensen A, Richter EA, Bangsbo J 2001 Allantoin formation and urate and glutatione exchange in human muscle during submaximal exercise. Free Radical Biol Med 31:1313-1322
9. Ueland PM, Mansoor MA, Guttormsen AB 1996 Reduced, oxidised and protein-bound forms of homocysteine and other aminothiols in plasma comprise the redox thiols status-a possible element of the extracellular antioxidant defence system. J Nutr 126:1281S-1284S
10. Giltay EJ, Hoogeveen EK, Elbers JM, Gooren LJ, Asscheman H, Stehouwer CD 1998 Effects of sex steroids on plasma total homocysteine levels: a study in transsexual males and females. J Clin Endocrinol Metab 83:550-553
11. McCarty MF 2000 Increased homocysteine associated with smoking, chronic inflammation, and ageing may reflect acute phase induction of pyridoxal phosphatase activity. Med Hypotheses 55:289-293
12. McCarty MF 2000 Insulin secretion a potential determinant of homocysteine levels. Med Hypotheses 55:454-455
13. Meigs JB, Jacques PF, Selhub J, Singer DE, Nathan DM, Rifai N, D'Agostino RB, Wilson PWF 2001 Fasting plasma homocysteine levels in the insulin resistance syndrome. Diabetes Care 24:1403-1410
14. Sheu WH, Lee WJ, Chen YD 2000 Plasma homocysteine concentrations and insulin sensitivity in hypertensive subjects. Am J Hypertens 13:14-20
15. Schachter M, Raziel A, Friedler S, Strassburger D, Bern O, Ron-El R 2003 Insulin resistance in patients with polycystic ovary syndrome is associated with elevated plasma homocysteine. Hum Reprod 18:721-727
16. Hak AE, Polderman KH, Westerdorp ICD, Jacobs C, Hofman A, Witteman JCM, Stehouwer CDA 2000 Increased plasma hormones homocysteine after menopause. Atherosclerosis 149:163-168
17. Van Baal WM, Smolders RG, van der Mooren MJ, Teerlink T, Kenemans P 1999 Hormone replacement therapy and plasma homocysteine levels. Obstet Gynecol 94:485-491
18. De Leo V, La Marca A, Morgante G, Ciani F, Zammarchi E, Setacci C 2000 Low dose folic acid supplementation reduces plasma levels of the cardiovascular risk factor homocysteine in postmenopausal women. Am J Obstet Gynecol 183:945-947
19. Van der Schouw YT, van der Graaf Y, Steyerberg EW, Eijkemans YC, Banga JD 1996 Age at menopause as a risk factor for cardiovascular mortality. Lancet 347:714-718
20. Loon AT 2000 Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 23:S4-S19
21. Cucinelli F, Paparella PL, Soranna L, Barini A, Cinque B, Mancuso S, Lanzone A 1999 Differential effect of transdermal estrogen plus progestagen replacement therapy on insulin metabolism in postmenopausal women: relation to their insulinemic secretion. Eur J Endocrinol 140:1215-1223
22. Faber OK, Christensen K, Kehelet H, Madsbad S, Binder C 1981 Decreased insulin removal contributes to hyperinsulinemic in obesity. J Clin Endocrinol Metab 53:618-621
23. Bergman RN, Finegood DT, Ader M 1985 Assessment of insulin sensitivity in vivo. Endocr Rev 53:45-86
24. Van der Griend R, Haas FJLM, Biesma DH, Duran M, Menwissen OJATH, Banga JD 1999 Combination of low dose folic acid and pyridoxine for treatment of hyperhomocysteinemia in patients with premature arterial disease and their relatives. Atherosclerosis 143:177-183
25. Refsum H, Fiskerstrand T, Guttormsen AB, Ueland PM 1997 Assessment of homocysteine status. J Inhert Metab Dis 20:286-294
26. Mansoor MA, Svardal AM, Ueland PM 1992 Determination of the in vivo redox status of cysteine, cysteinylglycine, homocysteine, and glutathione in human plasma. Anal Biochem 200:218-229
27. Woo KS, Chook P, Chan LL, Cheung AS, Fung WH, Qiao M, Lolin YI, Thomas GN, Sanderson JE, Metreweli C, Celermajer DS 2002 Long-term improvement in homocysteine levels and arterial endothelial function after 1-year folic acid supplementation. Am J Med 112:535-539
28. Wouters Mg, Moorrees MT, Van der Mooren MJ, Blom HJ, Boers GH, Schellekens LA, Thomas CM, Eskes TK 1995 Plasma homocysteine and menopausal status. Eur J Clin Invest 25:801-805
29. Lyons J, Rahu-Pfeiffer A, Yu YM, Lu XM, Zurakowsy D, Tompkins RG, Ajami AM Young VR, Castillo L 2000 Blood glutathione synthesis rates in healthy adults receiving a sulphur amino acid-free diet. Proc Natl Acad Sci USA 97:5071-5076
30. Wu G Fang Y-Z, Yang S, Lupton JR, Turner RD 2004 Glutathione metabolism and its implications for health. J Nutr 134:489-492
31. Smolders RGV, van der Mooren MJ, Teerlink T, Merkus JMWM, Kroeks MVAM, Franke HR, Stehouwer CDA, Kenemans P 2003 A randomized placebo-controlled study of the effect of transdermal vs. oral estradiol with or without gestodene on homocysteine levels. Fertil Steril 79:261-267
32. Bostom AG, Gohh RY, Tsai MY, Hopkins-Garcia BJ, Nadeau MR, Bianchi LA, Jacques PF, Rosemberg IH, Selhub J 1997 Excess prevalence of fasting and postmethionine-loading hyperhomocysteinemia in stable renal transplant recipient. Arterioscler Thromb Vasc Biol 17:1894-1900
33. Olszewski AJ, McCully KS 1991 Homocysteine content of lipoproteins in hypercholesterolaemia. Atherosclerosis 88:61-68
34. Earnest CP, Wood KA, Church TS 2003 Complex multivitamin supplementation improves homocysteine and resistance to LDL-C oxidation. J Am Coll Nutr 22:400-407
35. El-Swefy SE, Ali SI, Asker ME, Mohamed HE 2002 Hyperhomocysteinaemia and cardiovascular risk in female ovariectomized rats: role of folic acid and hormone replacement therapy. J Pharm Pharmacol 54:391-397
36. Paradisi G, Cucinelli F, Mele MC, Barini A, Lanzone A, Caruso A 2004 Endothelial function in post-menopausal women: effect of folic acid supplementation. Hum Reprod 19:1031-1035
37. Sanchez-Margalet V, Valle M, Ruz FJ, Gascon F, Mateo J, Goberna R 2002 Elevated plasma total homocysteine levels in hyperinsulinemic obese subjects, J Nutr Biochem 13:75-79
38. Giltay EJ, Hoogeveen EK, Elbers JM, Gooren LJ, Asscherman H, Stehouwer CD 2001 Insulin resistance is associated with elevated plasms total homocysteine levels in healthy, non obese subjects. Atherosclerosis 139:197-198
39. Dicker-Brown A, Fonseca VA, Fink LM, Kem PA 1999 The effect of glucose and insulin on the activity of enzymes in homocysteine metabolism. Diabetes 48(Suppl 1):A135
40. Ceriello A, Pirisi M 1995 Is oxidative stress the missing link between insulin resistance and atherosclerosis? Diabetologia 38:1484-1485
41. Wittmann L, Nagy J 1996 Are insulin resistance and atherosclerosis the consequences of oxidative stress? Diabetologia 39:1002-1003
42. Stamler JS, Osborne JA, Jaraki O, Rabbani LE, Mullins M, Singel D and Loscalzo J 1993 Adverse vascular effects of homocysteine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen. J Clin Invest 91:308-318
43. Setola E, Monti LD, Galluccio E, Palloshi A, Fragasso G, Paroni R, Magni F, Sandoli EP, Lucotti P, Costa S, Fermo I, Galli-Kienle M, Origgi A, Margonato A, Piatti P 2004 Insulin resistance and endothelial function are improved after folate and vitamin B12 therapy in patients with metabolic syndrome: relationship between homocysteine levels and hyperinsulinemia. Eur J Endocrinol 151:483-489
44. Gori T, Burstein JM, Ahmed S, Miner S, Al-Hesayen A, Kelly S, Parker JD 2001 Folic acid prevents nitroglycerin-induced nitric oxide synthase dysfunction and nitrate tolerance. A human in vivo study. Circulation 104:1119-1123
45. Najib S, Sanchez-Margalet V 2001 Homocysteine thiolactone inhibits insulin signalling and glutathione has a protective effect. J Mol Endocrinol 27:85-91
46. Abbasi F, Facchini F, Humphrejs MH, Reaven GM 1999 Plasma homocysteine concentrations in healthy volunteers are not related to differences in insulinmediated glucose disposal. Atherosclerosis 146:175-178