Exploration of melt granulation technique for the development of coprocessed directly compressible adjuvant containing lactose and microcrystalline cellulose

Pharmaceutical Development and Technology

Volumn 8, Issue 2, 2003, Pages 175-185

  Gohel, Mukesh C ^a   Jogani, Pranav D ^b  

^a L M COLLEGE OF PHARMACY   (India)

^b SBMS Coll Pharmaceut Educ/R   (India)

Author keywords

Direct compression; Factorial design; Lactose; Melt granulation; Microcrystalline cellulose; Polyethylene glycol; Polyvinyl pyrrolidone

Indexed keywords

ADJUVANT; AEROSIL; BINDING AGENT; CROSCARMELLOSE SODIUM; CROSPOVIDONE; DISINTEGRATING AGENT; GLYCYRRHIZA EXTRACT; LACTOSE; MACROGOL 4000; MAGNESIUM STEARATE; METFORMIN; MICROCRYSTALLINE CELLULOSE; PARACETAMOL; POVIDONE; STARCH GLYCOLATE SODIUM; TALC; UNCLASSIFIED DRUG;

ARTICLE; CURCUMA LONGA; DILUTION; DRUG GRANULATION; DRUG RELEASE; DRUG SOLUBILITY; FACTORIAL ANALYSIS; IN VITRO STUDY; PARTICLE SIZE; PRIORITY JOURNAL; REGRESSION ANALYSIS; TABLET COMPRESSION; TABLET DISINTEGRATION TIME; TABLET FRIABILITY; TENSILE STRENGTH;

ADJUVANTS, PHARMACEUTIC; ALGORITHMS; CELLULOSE; DRUG COMPOUNDING; DRUG INDUSTRY; LACTOSE; PARTICLE SIZE; POWDERS; TABLETS; TENSILE STRENGTH;

EID: 0038669014     PISSN: 10837450     EISSN: None     Source Type: Journal    
DOI: 10.1081/PDT-120018487     Document Type: Article

References (15)

1. Parrot, E.L. Milling. In From Theory and Practice of Industrial Pharmacy, 3rd ed.; Lachman, L., Liberman, H.A., Kanig, J.L., Eds.; Lea and Febiger: Philadelphia, 1986; 21-46.
2. Carr, R.L. Evaluating flow properties of solids. Chem. Eng. 1965, 72, 163-168.
3. Gohel, M.C.; Jogani, P.D. An investigation of the direct-compression characteristics of co-processed lactose-microcrystalline cellulose using statistical design. Pharm. Technol. 1999, 23 (11), 54-62.
4. Friability, in USP 24-NF 19, United States Pharmacopeial Convention Inc., Rockville, 2000; 2148.
5. Disintegration Time, in USP 24-NF 19 United States Pharmacopeial Convention Inc., Rockville, 2000; 1941.
6. Bozkir, A. Kinetic evaluation of the mechanical strength of briquette granules. Drug Dev. Ind. Pharm. 1997, 23 (6), 589-594.
7. Baykara, T.; Acarturk, F. The effect of binding agent on the friability and compressibility of granules. Drug Dev. Ind. Pharm. 1989, 15 (9), 1341-1351.
8. Kawakita, K.; Ludde, K.H. Some consideration on powder compression equations. Powd. Technol. 1970-71, 4, 61-68.
9. Niwa, T.; Takeuchi, H.; Hino, T.; Itoh, A.; Kawashima, Y.; Kichi, K. Preparation of agglomerated crystals for direct tableting and microencapsulation by the spherical crystallization technique with a continuous system. Pharm. Res. 1994, 11 (4), 478-484.
10. Acetaminophen Tablet, in USP 24-NF 19 (United States Pharmacopeial Convention Inc., Rockville, 2000; 20.
11. Metformin Hydrochloride Tablet, in Indian Pharmacopoeia Vol. I, the Controller of Publications, New Delhi, 1996; 470.
12. Fiese, E.F.; Hagen, T.A. Preformulation. In From Theory and Practice of Industrial Pharmacy; 3rd Ed. Lacman, L., Liberman, H.A., Kanig, J.L., Eds.; Lea and Febiger: Philadelphia, 1986; 171-194.
13. Price, J.C. Polyethylene Glycol in Hand book of Pharmaceutical Excipients; Wade, A., Weller, P.J., Eds.; The Pharmaceutical Press: London, 1994; 355-361.
14. Taylor, M.K.; Ginsburg, J.; Hickey, A.J.; Ciheyas, F. Composite method to quantify powder flow as a screening method in early tablet or capsule formulation development, AAPS Pharm. Sci. Tech. 1 (3), Article 18 (2000), http://www.pharmscitech.com/.
15. McChesney, J.D. Development of herbal medicinals: a pharmaceutical perspective. J. Herbal Pharmacother. 2001, 1 (2), 51-79.