Stabilization of sodium guaiazulene sulfonate in granules for tableting prepared using a twin-screw extruder

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 56, Issue 3, 2003, Pages 347-354

  Nakamichi, Kouichi ^a   Nakano, Tomio ^a   Yasuura, Hiroyuki ^a   Izumi, Shogo ^a   Kawashima, Yoshiaki ^b  

^a NIPPON SHINYAKU CO LTD   (Japan)

^b GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

A twin screw extruder; Sodium guaiazulene sulfonate; Stabilization; The kneading paddle elements; Uniformly dispersing; Water

Indexed keywords

GUALENATE SODIUM; LACTOSE; POLYVINYL ALCOHOL; POVIDONE; STARCH; WATER;

ARTICLE; CRYSTALLIZATION; DEVICE; DRUG DECOMPOSITION; DRUG STABILITY; FLUIDIZED BED GRANULATION; INTERMETHOD COMPARISON; SCREW GRANULATION; TABLET FORMULATION; TECHNIQUE; TWIN SCREW EXTRUSION;

EID: 0242288843     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0939-6411(03)00100-0     Document Type: Article

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