Shared and unique susceptibility genes in a mouse model of Graves' disease determined in BXH and CXB recombinant inbred mice

Endocrinology

Volumn 149, Issue 4, 2008, Pages 2001-2009

  McLachlan, Sandra M ^a,c   Aliesky, Holly A ^a   Pichurin, Pavel N ^a   Chen, Chun Rong ^a   Williams, Robert W ^b   Rapoport, Basil ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^c CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN; THYROTROPIN RECEPTOR ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; GRAVES DISEASE; HYPERTHYROIDISM; IMMUNOPATHOGENESIS; INBRED STRAIN; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; AUTOANTIBODIES; GENETIC PREDISPOSITION TO DISEASE; GRAVES DISEASE; HYPERTHYROIDISM; LINKAGE (GENETICS); MAJOR HISTOCOMPATIBILITY COMPLEX; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; QUANTITATIVE TRAIT LOCI; RECOMBINATION, GENETIC; X CHROMOSOME;

EID: 41549102933     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2007-1517     Document Type: Article

References (34)

1. Kaithamana S, Fan J, Osuga Y, Liang SG, Prabhakar BS 1999 Induction of experimental autoimmune Graves' disease in BALB/c mice. J Immunol 163:5157-5164
2. Kita-Furuyama M, Nagayama Y, Pichurin P, McLachlan SM, Rapoport B, Eguchi K 2003 Dendritic cells infected with adenovirus expressing the thyrotropin receptor induce Graves' hyperthyroidism in BALB/c mice. Clin Exp Immunol 131:234-240
3. Nagayama Y, Kita-Furuyama M, Ando T, Nakao K, Mizuguchi H, Hayakawa T, Eguchi K, Niwa M 2002 A novel murine model of Graves' hyperthyroidism with intramuscular injection of adenovirus expressing the thyrotropin receptor. J Immunol 168:2789-2794
4. Chen CR, Pichurin P, Nagayama Y, Latrofa F, Rapoport B, McLachlan SM 2003 The thyrotropin receptor autoantigen in Graves' disease is the culprit as well as the victim. J Clin Invest 111:1897-1904
5. Chen CR, Aliesky H, Pichurin PN, Nagayama Y, McLachlan SM, Rapoport B 2004 Susceptibility rather than resistance to hyperthyroidism is dominant in a thyrotropin receptor adenovirus-induced animal model of Graves' disease as revealed by BALB/c-C57BL/6 hybrid mice. Endocrinology 145:4927-4933
6. Yamaguchi K-I, Shimojo N, Kikuoka S, Hoshioka A, Hirai A, Tahara K, Kohn LD, Kohno Y, Niimi H 1997 Genetic control of anti-thyrotropin receptor antibody generation in H-2k mice immunized with thyrotropin receptor-transfected fibroblasts. J Clin Endocrinol Metab 82:4266-4269
7. Nagayama Y, McLachlan SM, Rapoport B, Niwa M 2003 A major role for non-MHC genes, but not for micro-organisms, in a novel model of Graves' hyperthyroidism. Thyroid 13:233-238
8. Shimojo N, Kohno Y, Yamaguchi KI, Kikuoka SI, Hoshioka A, Niimi H, Hirai A, Tamura Y, Saito Y, Kohn LD, Tahara K 1996 Induction of Graves-like disease in mice by immunization with fibroblasts transfected with the thyrotropin receptor and a class II molecule. Proc Natl Acad Sci USA 93:11074-11079
9. McLachlan SM, Nagayama Y, Rapoport B 2005 Insight into Graves' hyperthyroidism from animal models. Endocr Rev 26:800-832
10. Williams RW, Gu L, Qi S, Lu L 2001 The genetic structure of recombinant inbred mice: high-resolution consensus maps for complex trait analysis. Genome Biol 2:Research0046.1-0046.18
11. Aliesky HA, Pichurin PN, Chen CR, Williams RW, Rapoport B, McLachlan SM 2006 Probing the genetic basis for thyrotropin receptor antibodies and hyperthyroidism in immunized CXB recombinant inbred mice. Endocrinology 147:2789-2800
12. Shifman S, Bell JT, Copley RR, Taylor MS, Williams RW, Mott R, Flint J 2006 A high-resolution single nucleotide polymorphism genetic map of the mouse genome. PLoS Biol 4:e395
13. Chen CR, Aliesky HA, Guo J, Rapoport B, McLachlan SM 2006 Blockade of costimulation between T cells and antigen-presenting cells: an approach to suppress murine Graves' disease induced using thyrotropin receptor-expressing adenovirus. Thyroid 16:427-434
14. Mittereder N, March KL, Trapnell BC 1996 Evaluation of the concentration and bioactivity of adenovirus vectors for gene therapy. J Virol 70:7498-7509
15. Chazenbalk GD, Jaume JC, McLachlan SM, Rapoport B 1997 Engineering the human thyrotropin receptor ectodomain from a non-secreted form to a secreted, highly immunoreactive glycoprotein that neutralizes autoantibodies in Graves' patients' sera. J Biol Chem 272:18959-18965
16. Chazenbalk GD, Wang Y, Guo J, Hutchison JS, Segal D, Jaume JC, McLachlan SM, Rapoport B 1999 A mouse monoclonal antibody to a thyrotropin receptor ectodomain variant provides insight into the exquisite antigenic conformational requirement, epitopes and in vivo concentration of human autoantibodies. J Clin Endocrinol Metab 84:702-710
17. Churchill GA, Doerge RW 1994 Empirical threshold values for quantitative trait mapping. Genetics 138:963-971
18. Belknap JK, Crabbe JC, Plomin R, McClearn GE, Sampson KE, O'Toole LA, Gora-Maslak G 1992 Single-locus control of saccharin intake in BXD/Ty recombinant inbred (RI) mice: some methodological implications for RI strain analysis. Behav Genet 22:81-100
19. Williams RW, Strom RC, Goldowitz D 1998 Natural variation in neuron number in mice is linked to a major quantitative trait locus on Chr 11. J Neurosci 18:138-146
20. Poltorak A, He X, Smirnova I, Liu MY, Van Huffel C, Du X, Birdwell D, Alejos E, Silva M, Galanos C, Freudenberg M, Ricciardi-Castagnoli P, Layton B, Beutler B 1998 Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282:2085-2088
21. Airey DC, Lu L, Williams RW 2001 Genetic control of the mouse cerebellum: identification of quantitative trait loci modulating size and architecture. J Neurosci 21:5099-5109
22. Scalzo AA, Fitzgerald NA, Wallace CR, Gibbons AE, Smart YC, Burton RC, Shellam GR 1992 The effect of the Cmv-1 resistance gene, which is linked to the natural killer cell gene complex, is mediated by natural killer cells. J Immunol 149:581-589
23. Mountz JD, Yang P, Wu Q, Zhou J, Tousson A, Fitzgerald A, Allen J, Wang X, Cartner S, Grizzle WE, Yi N, Lu L, Williams RW, Hsu HC 2005 Genetic segregation of spontaneous erosive arthritis and generalized autoimmune disease in the BXD2 recombinant inbred strain of mice. Scand J Immunol 61:128-138
24. Pohlenz J, Maqueem A, Cua K, Weiss RE, Van Sande J, Refetoff S 1999 Improved radioimmunoassay for measurement of mouse thyrotropin in serum: strain differences in thyrotropin concentration and thyrotroph sensitivity to thyroid hormone. Thyroid 9:1265-1271
25. Schoenmakers CH, Pigmans IG, Poland A, Visser TJ 1993 Impairment of the selenoenzyme type I iodothyronine deiodinase in C3H/He mice. Endocrinology 132:357-361
26. Moeller LC, Alonso M, Liao X, Broach V, Dumitrescu A, Van Sande J, Montanelli L, Skjei S, Goodwin C, Grasberger H, Refetoff S, Weiss RE 2007 Pituitary-thyroid setpoint and thyrotropin receptor expression in consomic rats. Endocrinology 148:4727-4733
27. Staff of The Jackson Laboratory 1997 Handbook on genetically standardized Jax mice. 5th ed. Bar Harbor, ME: Jackson Laboratory
28. Retter I, Chevillard C, Scharfe M, Conrad A, Hafner M, Im TH, Ludewig M, Nordsiek G, Severitt S, Thies S, Mauhar A, Blocker H, Muller W, Riblet R 2007 Sequence and characterization of the Ig heavy chain constant and partial variable region of the mouse strain 129S1. J Immunol 179:2419-2427
29. Yoshida H, Fossati L, Yoshida M, Abdelmoula M, Herrera S, Merino J, Lambert PH, Izui S 1988 Igh-C allotype-linked control of anti-DNA production and clonotype expression in mice infected with Plasmodium yoelii. J Immunol 141:2125-2131
30. Dechairo BM, Zabaneh D, Collins J, Brand O, Dawson GJ, Green AP, Mackay I, Franklyn JA, Connell JM, Wass JA, Wiersinga WM, Hegedus L, Brix T, Robinson BG, Hunt PJ, Weetman AP, Carey AH, Gough SC 2005 Association of the TSHR gene with Graves' disease: the first disease specific locus. Eur J Hum Genet 13:1223-1230
31. Jacobson EM, Tomer Y 2007 The genetic basis of thyroid autoimmunity. Thyroid 17:949-961
32. Burton PR, Clayton DG, Cardon LR, Craddock N, Deloukas P, Duncanson A, Kwiatkowski DP, McCarthy MI, Ouwehand WH, Samani NJ, Todd JA, Donnelly CP, Barrett JC, Burton PR, Davison D, Donnelly P, Easton D, Evans DM, Leung HT, Marchini JL, Morris AP, Spencer CC, Tobin MD, Cardon LR, Clayton DG, et al. 2007 Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet 39:1329-1337
33. Pearce S, Sutherland A, Davies J, Owen C, Cordell H, Timms K, Tran T, Abkevich V, Gutin A, Lanchbury JS, Merriman T 2007 Genome-wide scan for association using 417,000 SNP markers in Graves' disease. Thyroid 17(Suppl 1): S-45 (Abstract)
34. Simmonds MJ, Heward JM, Carr-Smith J, Foxall H, Franklyn JA, Gough SC 2006 Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease. J Clin Endocrinol Metab 91:1051-1061