Functional characterization of the NF-κB transcription factor gene REL2 from Anopheles gambiae

Insect Science

Volumn 14, Issue 3, 2007, Pages 175-184

  Hoa, Ngo T ^a,b   Zheng, Liangbiao ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY COLLEGE LONDON HOSPITALS   (United Kingdom)

Author keywords

Antimicrobial; Innate immunity; Malaria; Mosquito; NF B

Indexed keywords

ANOPHELES GAMBIAE; ANOPHELES STEPHENSI; BACILLUS SUBTILIS; BACTERIA (MICROORGANISMS); BASSIANA; ESCHERICHIA COLI; FUNGI;

EID: 41549098682     PISSN: 16729609     EISSN: 17447917     Source Type: Journal    
DOI: 10.1111/j.1744-7917.2007.00141.x     Document Type: Article

References (30)

1. Abraham, E.G., Pinto, S.B., Ghosh, A., Vanlandingham, D.L., Budd, A., Higgs, S., Kafatos, F.C., Jacobs-Lorena, M. and Michel, K. (2005) An immune-responsive serpin, SRPN6, mediates mosquito defense against malaria parasites. Proceedings of the National Academy of Sciences of the United Slates of America, 102, 16327-16332.
2. Arrighi, R.B., Lycett, G., Mahairaki, V., Siden-Kiamos, I. and Louis, C. (2005) Laminin and the malaria parasite's journey through the mosquito midgut. Journal of Experimental Biology, 208, 2497-2502.
3. Barillas-Mury, C., Charlesworth, A., Gross, I., Richman, A., Hoffmann, J.A. and Kafatos, F.C. (1996) Immune factor Gambif1, a new rel family member from the human malaria vector, Anopheles gambiae. The EMBO Journal, 15, 4961-4701.
4. Bian, G., Shin, S.W., Cheon, H.M., Kokoza, V. and Raikhel, A. S. (2005) Transgenic alteration of Toll immune pathway in the female mosquito Aedes aegypti. Proceedings of the National Academy of Sciences of the United States of America, 102, 13568-13573.
5. Blandin, S., Shiao, S.H., Moita, L.F., Janse, C.J., Waters, A.P., Kafatos, F.C. and Levashina, E.A. (2004) Complement-like protein TEP1 is a determinant of vectorial capacity in the malaria vector Anopheles gambiae. Cell, 116, 661-670.
6. Chen, P., Rodriguez, A., Erskine, R., Thach, T. and Abrams, J.M. (1998) Dredd, a novel effector of the apoptosis activators reaper, grim, and hid in Drosophila. Developmental Biology, 201, 202-216.
7. Christophides, G.K., Zdobnov, E., Barillas-Mury, C., Birney, E., Blandin, S., Blass, C., Brey, P.T., Collins, F.H., Danielli, A., Dimopoulos, G., Hetru, C., Hoa, N.T., Hoffmann, J.A., Kanzok, S.M., Letunic, I., Levashina, E.A., Loukeris, T.G., Lycett, G., Meister, S., Michel, K., Moita, L.F., Muller, H.M., Osta, M.A., Paskewitz, S.M., Reichhart, J.M., Rzhetsky, A., Troxler, L., Vemick, K.D., Vlachou, D., Volz, J., von Mering, C., Xu, J., Zheng, L., Bork, P. and Kafatos, F.C. (2002) Immunity-related genes and gene families in Anopheles gambiae. Science, 298, 159-165.
8. De Gregorio, E., Spellman, P.T., Tzou, P., Rubin, G.M. and Lemaitre, B. (2002) The Toll and Imd pathways are the major regulators of the immune response in Drosophila. The EMBO Journal, 21, 2568-2579.
9. Foley, E. and O'Farrell, P.H. (2004) Functional dissection of an innate immune response by a genome-wide RNAi screen. PLoS Biology, 2, E203.
10. Frolet, C., Thoma, M., Blandin, S., Hoffmann, J.A. and Levashina, E.A. (2006) Boosting NF-kappaB-dependent basal immunity of Anopheles gambiae aborts development of Plasmodium berghei. Immunity, 25, 677-685.
11. Holt, R.A., Subramanian, G.M., Halpern, A., Sutton, G.G., Charlab, R., Nusskern, D.R., Wincker, P., Clark, A.G., Ribeiro, J.M., Wides, R., Salzberg, S.L., Loftus, B., Yandell, M., Majoras, W.H., Rusch, D.B., Lai, Z., Kraft, C.L., Abril, J.F., Anthouard, V., Arensburger, P., Atkinson, P. W., Baden, H., de Berardinis, V., Baldwin, D., Benes, V., Biedler, J., Blass, C., Bolanos, R., Boscus, D., Barnstead, M., Cai, S., Center, A., Chatuverdi, K., Christophides, G.K., Chrystal, M.A., Clamp, M., Cravchik, A., Curwen, V., Dana, A., Delcher, A., Dew, I., Evans, C.A., Flanigan, M., Grundschober-Freimoser, A., Friedli, L., Gu, Z., Guan, P., Guigo, R., Hillenmeyer, M.E., Hladun, S.L., Hogan, J.R., Hong, Y.S., Hoover, J., Jaillon, O., Ke, Z., Kodira, C., Kokoza, E., Koutsos, A., Letunic, I., Levitsky, A., Liang, Y., Lin, J.J., Lobo, N.F., Lopez, J.R., Malek, J.A., McIntosh, T.C., Meister, S., Miller, J., Mobarry, C., Mongin, E., Murphy, S.D., O'Brochta, D.A., Pfannkoch, C., Qi, R., Regier, M.A., Remington, K., Shao, H., Sharakhova, M. V., Sitter, C.D., Shetty, J., Smith, T.J., Strong, R., Sun, J., Thomasova, D., Ton, L.Q., Topalis, P., Tu, Z., Unger, M.F., Walenz, B., Wang, A., Wang, J., Wang, M., Wang, X., Woodford, K.J., Wormian, J.R., Wu, M., Yao, A., Zdobnov, E. M., Zhang, H. and Zhao, Q. (2002) The genome sequence of the malaria mosquito Anopheles gambiae. Science, 298, 129-149.
12. Khush, R.S., Cornwell, W.D., Uram, J.N. and Lemaitre, B. (2002) A ubiquitin-proteasome pathway represses the Drosophila immune deficiency signaling cascade. Current Biology, 12, 1728-1737.
13. Kim, W., Koo, H., Richman, A.M., Seeley, D., Vizioli, J., Klocko, A.D. and O'Brochta, D.A., (2004) Ectopic expression of a cecropin transgene in the human malaria vector mosquito Anopheles gambiae (Diptera: Culicidae): effects on susceptibility to Plasmodium. Journal of Medical Entomology, 41, 447-455.
14. Luna, C., Hoa, N.T., Lin, H., Zhang, L., Nguyen, H.L.A., Kanzok, S.M. and Zheng, L. (2006) Expression of immune responsive genes in cell lines from two different Anopheline species. Insect Molecular Biology, 15, 721-729.
15. Meister, S., Kanzok, S.M., Zheng, X.L., Luna, C., Li, T.R., Hoa, N.T., Clayton, J.R., White, K.P., Kafatos, F.C., Christophides, G.K. and Zheng, L. (2005) Immune signaling pathways regulating bacterial and malaria parasite infection of the mosquito Anopheles gambiae. Proceedings of the National Academy of Sciences of the United States of America, 102, 11420-11425.
16. Michel, K., Budd, A., Pinto, S., Gibson, T.J. and Kafatos, F.C. (20055 Anopheles gambiae SRPN2 facilitates midgut invasion by the malaria parasite Plasmodium berghei. EMBO Reports, 6, 891-897.
17. Muller, H.M., Dimopoulos, G., Blass, C. and Kafatos, F.C. (1999) A hemocyte-like cell line established from the malaria vector Anopheles gambiae expresses six prophenoloxidase genes. Journal Biological Chemistry, 274, 11727-11735.
18. Osta, M.A., Christophides, G.K. and Kafatos, F.C. (2004) Effects of mosquito genes on Plasmodium development. Science, 303, 2030-2032.
19. Richman, A.M., Dimopoulos, G., Seeley, D. and Kafatos, F.C. (1997) Plasmodium activates the innate immune response of Anopheles gambiae mosquitoes. The EMBO Journal, 16, 6114-6119.
20. Royet, J., Reichhart, J.M. and Hoffmann, J.A. (2005) Sensing and signaling during infection in Drosophila. Current Opinion in Immunology, 17, 11-17.
21. Shin, S.W., Kokoza, V., Ahmed, A. and Raikhel, A.S. (2002) Characterization of three alternatively spliced isoforms of the Rel/NF-kappa B transcription factor Relish from the mosquito Aedes aegypti. Proceedings of the National Academy of Sciences of the United States of America, 99, 9978-9983.
22. Shin, S.W., Kokoza, V., Bian, G., Cheon, H.-M., Kim, Y.J. and Raikhel, A.S. (2005) Rel 1, a homologue of Drosophila Dorsal, regulates Toll antifungal immune pathway in the female mosquito Aedes aegypti. Journal Biological Chemistry, 280, 16499-16507.
23. Shin, S.W., Kokoza, V., Lobkov, I. and Raikhel, A.S. (2003) Relish-mediated immune deficiency in the transgenic mosquito Aedes aegypti. Proceedings of the National Academy of Sciences of the United States of America, 100, 2616-2621.
24. Stoven, S., Silverman, N., Junell, A., Hedengren-Olcott, M., Erturk, D., Engstrom, Y., Maniatis, T. and Hultmark, D. (2003) Caspase-mediated processing of the Drosophila NF-kappa B factor Relish. Proceedings of the National Academy of Sciences of the United States of America, 100, 5991-5996.
25. Tanaka, H., Yamamoto, M., Moriyama, Y., Yamao, M., Furukawa, S., Sagisaka, A., Nakazawa, H., Mori, H. and Yamakawa, M. (2005) A novel Rel protein and shortened isoform that differentially regulate antibacterial peptide genes in the silkworm Bombyx mori. Biochimica et Biophysica Acta, 1730, 10-21.
26. Tauszig, S., Jouanguy, E., Hoffmann, J.A. and Imler, J.-L. (2000) Toll related receptors and the control of antimicrobial peptide expression in Drosophila. Proceedings of the National Academy of Sciences of the United States of America, 97, 10520-10525.
27. Thornberry, N.A., Rano, T.A., Peterson, E.P., Rasper, D.M., Timkey, T., Garcia-Calvo, M., Houtzager, V.M., Nordstrom, P.A., Roy, S., Vaillancourt, J.P., Chapman, K.T. and Nicholson, D.W. (1997) A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis. Journal of Biological Chemistry, 272, 17907-17911.
28. Vizioli, J., Bulet, P., Charlet, M., Lowenberger, C., Blass, C., Muller, H.M., Dimopoulos, G., Hoffmann, J., Kafatos, F.C. and Richman, A. (2000) Cloning and analysis of a cecropin gene from the malaria vector mosquito, Anopheles gambiae. Insect Molecular Biology, 9, 75-84.
29. Vizioli, J., Bulet, P., Hoffmann, J.A., Kafatos, F.C., Muller, H.M. and Dimopoulos, G. (2001) Gambicin: a novel immune responsive antimicrobial peptide from the malaria vector Anopheles gambiae. Proceedings of the National Academy of Sciences of the United States of America, 98, 12630-12635.
30. Zheng, X.L. and Zheng, A.L. (2002) Genomic organization and regulation of three cecropin genes in Anopheles gambiae. Insect Molecular Biology, 11, 517-525.