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Volumn 149, Issue 4, 2008, Pages 1987-1993

Tissue selectivity of the anabolic steroid, 19-nor-4-androstenediol- 3β,17β-diol in male sprague dawley rats: Selective stimulation of muscle mass and bone mineral density relative to prostate mass

Author keywords

[No Author keywords available]

Indexed keywords

19 NOR 4 ANDROSTENEDIOL 3BETA,17BETA DIOL; ANDROSTANOLONE; ANDROSTENEDIOL DERIVATIVE; GONADOTROPIN; NANDROLONE; SILASTIC; TESTOSTERONE; UNCLASSIFIED DRUG;

EID: 41549098279     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2007-0956     Document Type: Article
Times cited : (22)

References (42)
  • 1
    • 15944404290 scopus 로고    scopus 로고
    • Exogenous testosterone (T) alone or with finasteride increases physical performance, grip strength, and lean body mass in older men with low serum T
    • Page ST, Amory JK, Bowman FD, Anawalt BD, Matsumoto AM, Bremner WJ, Tenover JL 2005 Exogenous testosterone (T) alone or with finasteride increases physical performance, grip strength, and lean body mass in older men with low serum T. J Clin Endocrinol Metab 90:1502-1510
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 1502-1510
    • Page, S.T.1    Amory, J.K.2    Bowman, F.D.3    Anawalt, B.D.4    Matsumoto, A.M.5    Bremner, W.J.6    Tenover, J.L.7
  • 3
    • 33847184616 scopus 로고    scopus 로고
    • Expanding the therapeutic use of androgens via selective androgen receptor modulators (SARMs)
    • Gao W, Dalton JT 2007 Expanding the therapeutic use of androgens via selective androgen receptor modulators (SARMs). Drug Discov Today 12:241-248
    • (2007) Drug Discov Today , vol.12 , pp. 241-248
    • Gao, W.1    Dalton, J.T.2
  • 5
    • 33746511532 scopus 로고    scopus 로고
    • Effects of resistance exercise training and nandrolone decanoate on body composition and muscle function among patients who receive hemodialysis: A randomized, controlled trial
    • Johansen KL, Painter PL, Sakkas GK, Gordon P, Doyle J, Shubert T 2006 Effects of resistance exercise training and nandrolone decanoate on body composition and muscle function among patients who receive hemodialysis: a randomized, controlled trial. J Am Soc Nephrol 17:2307-2314
    • (2006) J Am Soc Nephrol , vol.17 , pp. 2307-2314
    • Johansen, K.L.1    Painter, P.L.2    Sakkas, G.K.3    Gordon, P.4    Doyle, J.5    Shubert, T.6
  • 6
    • 1842689292 scopus 로고    scopus 로고
    • The anabolic androgenic steroid oxandrolone in the treatment of wasting and catabolic disorders: Review of efficacy and safety
    • Orr R, Fiatarone Singh M 2004 The anabolic androgenic steroid oxandrolone in the treatment of wasting and catabolic disorders: review of efficacy and safety. Drugs 64:725-750
    • (2004) Drugs , vol.64 , pp. 725-750
    • Orr, R.1    Fiatarone Singh, M.2
  • 7
    • 0035079075 scopus 로고    scopus 로고
    • Use of steroids for self-enhancement: An epidemiologic/societal perspective
    • Yesalis CE 2001 Use of steroids for self-enhancement: an epidemiologic/societal perspective. AIDS Read 11:157-160
    • (2001) AIDS Read , vol.11 , pp. 157-160
    • Yesalis, C.E.1
  • 8
    • 33746071218 scopus 로고    scopus 로고
    • Quantitative determination of metabolic products of 19-norandrostenediol in human plasma using gas chromatography/mass spectrometry
    • Schrader Y, Thevis M, Schanzer W 2006 Quantitative determination of metabolic products of 19-norandrostenediol in human plasma using gas chromatography/mass spectrometry. Drug Metab Dispos 34:1328-1335
    • (2006) Drug Metab Dispos , vol.34 , pp. 1328-1335
    • Schrader, Y.1    Thevis, M.2    Schanzer, W.3
  • 10
    • 0037622805 scopus 로고    scopus 로고
    • Randomized placebo-controlled trial of androgen effects on muscle and bone in men requiring long-term systemic glucocorticoid treatment
    • Crawford BA, Liu PY, Kean MT, Bleasel JF, Handelsman DJ 2003 Randomized placebo-controlled trial of androgen effects on muscle and bone in men requiring long-term systemic glucocorticoid treatment. J Clin Endocrinol Metab 88:3167-3176
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 3167-3176
    • Crawford, B.A.1    Liu, P.Y.2    Kean, M.T.3    Bleasel, J.F.4    Handelsman, D.J.5
  • 11
    • 20744460348 scopus 로고    scopus 로고
    • The effect of nandrolone decanoate on bone mineral density, muscle mass, and hemoglobin levels in elderly women with osteoporosis: A double-blind, randomized, placebo-controlled clinical trial
    • Frisoli Jr A, Chaves PH, Pinheiro MM, Szejnfeld VL 2005 The effect of nandrolone decanoate on bone mineral density, muscle mass, and hemoglobin levels in elderly women with osteoporosis: a double-blind, randomized, placebo-controlled clinical trial. J Gerontol A Biol Sci Med Sci 60:648-653
    • (2005) J Gerontol A Biol Sci Med Sci , vol.60 , pp. 648-653
    • Frisoli Jr, A.1    Chaves, P.H.2    Pinheiro, M.M.3    Szejnfeld, V.L.4
  • 12
    • 0025779159 scopus 로고
    • Influence of anabolic steroids on body composition, blood pressure, lipid profile and liver functions in body builders
    • Kuipers H, Wijnen JA, Hartgens F, Willems SM 1991 Influence of anabolic steroids on body composition, blood pressure, lipid profile and liver functions in body builders. Int J Sports Med 12:413-418
    • (1991) Int J Sports Med , vol.12 , pp. 413-418
    • Kuipers, H.1    Wijnen, J.A.2    Hartgens, F.3    Willems, S.M.4
  • 13
    • 0020409016 scopus 로고
    • Relative binding affinities of testosterone, 19-nortestosterone and their 5α-reduced derivatives to the androgen receptor and to other androgen-binding proteins: A suggested role of 5α-reductive steroid metabolism in the dissociation of "myotropic" and "androgenic" activities of 19-nortestosterone
    • Toth M, Zakar T 1982 Relative binding affinities of testosterone, 19-nortestosterone and their 5α-reduced derivatives to the androgen receptor and to other androgen-binding proteins: a suggested role of 5α-reductive steroid metabolism in the dissociation of "myotropic" and "androgenic" activities of 19-nortestosterone. J Steroid Biochem 17:653-660
    • (1982) J Steroid Biochem , vol.17 , pp. 653-660
    • Toth, M.1    Zakar, T.2
  • 14
    • 0029068573 scopus 로고
    • Different patterns of metabolism determine the relative anabolic activity of 19-norandrogens
    • Sundaram K, Kumar N, Monder C, Bardin CW 1995 Different patterns of metabolism determine the relative anabolic activity of 19-norandrogens. J Steroid Biochem Mol Biol 53:253-257
    • (1995) J Steroid Biochem Mol Biol , vol.53 , pp. 253-257
    • Sundaram, K.1    Kumar, N.2    Monder, C.3    Bardin, C.W.4
  • 15
    • 0035657262 scopus 로고    scopus 로고
    • Suppression of spermatogenesis to azoospermia by combined administration of GnRH antagonist and 19-nortestosterone cannot be maintained by this nonaromatizable androgen alone
    • Behre HM, Kliesch S, Lemcke B, von Eckardstein S, Nieschlag E 2001 Suppression of spermatogenesis to azoospermia by combined administration of GnRH antagonist and 19-nortestosterone cannot be maintained by this nonaromatizable androgen alone. Hum Reprod 16:2570-2577
    • (2001) Hum Reprod , vol.16 , pp. 2570-2577
    • Behre, H.M.1    Kliesch, S.2    Lemcke, B.3    von Eckardstein, S.4    Nieschlag, E.5
  • 16
    • 0018758023 scopus 로고
    • Differences in steroid specificity for rat androgen binding protein and the cytoplasmic receptor
    • Cunningham GR, Tindall DJ, Means AR 1979 Differences in steroid specificity for rat androgen binding protein and the cytoplasmic receptor. Steroids 33:261-276
    • (1979) Steroids , vol.33 , pp. 261-276
    • Cunningham, G.R.1    Tindall, D.J.2    Means, A.R.3
  • 18
    • 33748302967 scopus 로고    scopus 로고
    • You say estren, I say estrogen. Let's call the whole replacement off!
    • Neill US 2006 You say estren, I say estrogen. Let's call the whole replacement off! J Clin Invest 116:2327-2329
    • (2006) J Clin Invest , vol.116 , pp. 2327-2329
    • Neill, U.S.1
  • 19
    • 33750589516 scopus 로고    scopus 로고
    • Manolagas SC, Jilka RL, Kousteni S, Bellido T, Weinstein RS, O'Brien CA, Plotkin L, Han L 2006 Response to Windahl et al. J Clin Invest 116:2834
    • Manolagas SC, Jilka RL, Kousteni S, Bellido T, Weinstein RS, O'Brien CA, Plotkin L, Han L 2006 Response to Windahl et al. J Clin Invest 116:2834
  • 21
    • 0038819062 scopus 로고    scopus 로고
    • Kinase-mediated regulation of common transcription factors accounts for the bone-protective effects of sex steroids
    • Kousteni S, Han L, Chen JR, Almeida M, Plotkin LI, Bellido T, Manolagas SC 2003 Kinase-mediated regulation of common transcription factors accounts for the bone-protective effects of sex steroids. J Clin Invest 111:1651-1664
    • (2003) J Clin Invest , vol.111 , pp. 1651-1664
    • Kousteni, S.1    Han, L.2    Chen, J.R.3    Almeida, M.4    Plotkin, L.I.5    Bellido, T.6    Manolagas, S.C.7
  • 22
    • 0035018612 scopus 로고    scopus 로고
    • Perspective: Nonreproductive sites of action of reproductive hormones
    • Manolagas SC, Kousteni S 2001 Perspective: nonreproductive sites of action of reproductive hormones. Endocrinology 142:2200-2204
    • (2001) Endocrinology , vol.142 , pp. 2200-2204
    • Manolagas, S.C.1    Kousteni, S.2
  • 23
    • 41549091683 scopus 로고
    • The myotrophic and androgenic effects of 17-ethyl-19-nortestosterone and related compounds
    • Saunders FJ, Drill VA 1956 The myotrophic and androgenic effects of 17-ethyl-19-nortestosterone and related compounds. Endocrinology 58:567-572
    • (1956) Endocrinology , vol.58 , pp. 567-572
    • Saunders, F.J.1    Drill, V.A.2
  • 24
    • 84964130498 scopus 로고
    • Myotrophic activity of 19-nortestosterone and other steroids determined by modified levator ani muscle method
    • Hershberger LG, Shipley EG, Meyer RK 1953 Myotrophic activity of 19-nortestosterone and other steroids determined by modified levator ani muscle method. Proc Soc Exp Biol Med 83:175-180
    • (1953) Proc Soc Exp Biol Med , vol.83 , pp. 175-180
    • Hershberger, L.G.1    Shipley, E.G.2    Meyer, R.K.3
  • 25
    • 33746894825 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of nonsteroidal androgen receptor ligands
    • Gao W, Kim J, Dalton JT 2006 Pharmacokinetics and pharmacodynamics of nonsteroidal androgen receptor ligands. Pharm Res 23:1641-1658
    • (2006) Pharm Res , vol.23 , pp. 1641-1658
    • Gao, W.1    Kim, J.2    Dalton, J.T.3
  • 26
    • 0027256527 scopus 로고
    • A re-evaluation of the anabolic effect of testosterone in rats: Interactions with gonadectomy, adrenalectomy and hypophysectomy
    • Woodward CJ 1993 A re-evaluation of the anabolic effect of testosterone in rats: interactions with gonadectomy, adrenalectomy and hypophysectomy. Acta Endocrinol (Copenh) 128:473-477
    • (1993) Acta Endocrinol (Copenh) , vol.128 , pp. 473-477
    • Woodward, C.J.1
  • 27
    • 0017237021 scopus 로고
    • Androgenic control of food intake and body weight in male rats
    • Gentry RT, Wade GN 1976 Androgenic control of food intake and body weight in male rats. J Comp Physiol Psychol 90:18-25
    • (1976) J Comp Physiol Psychol , vol.90 , pp. 18-25
    • Gentry, R.T.1    Wade, G.N.2
  • 28
    • 0036172338 scopus 로고    scopus 로고
    • Testosterone (T)-induced changes in arcuate nucleus cocaine-amphetamine-regulated transcript and NPY mRNA are attenuated in old compared to young male brown Norway rats: Contribution of T to age-related changes in cocaine-amphetamine-regulated transcript and NPY gene expression
    • Sohn EH, Wolden-Hanson T, Matsumoto AM 2002 Testosterone (T)-induced changes in arcuate nucleus cocaine-amphetamine-regulated transcript and NPY mRNA are attenuated in old compared to young male brown Norway rats: contribution of T to age-related changes in cocaine-amphetamine-regulated transcript and NPY gene expression. Endocrinology 143:954-963
    • (2002) Endocrinology , vol.143 , pp. 954-963
    • Sohn, E.H.1    Wolden-Hanson, T.2    Matsumoto, A.M.3
  • 30
    • 0032996822 scopus 로고    scopus 로고
    • Cross-sectional and longitudinal analysis of age-associated changes in body composition of male Brown Norway rats: Association of serum leptin levels with peripheral adiposity
    • Wolden-Hanson T, Marck BT, Smith L, Matsumoto AM 1999 Cross-sectional and longitudinal analysis of age-associated changes in body composition of male Brown Norway rats: association of serum leptin levels with peripheral adiposity. J Gerontol A Biol Sci Med Sci 54:B99-B107
    • (1999) J Gerontol A Biol Sci Med Sci , vol.54
    • Wolden-Hanson, T.1    Marck, B.T.2    Smith, L.3    Matsumoto, A.M.4
  • 33
    • 0036752771 scopus 로고    scopus 로고
    • Effects of norandrostenedione and norandrostenediol in resistance-trained men
    • van Gammeren D, Falk D, Antonio J 2002 Effects of norandrostenedione and norandrostenediol in resistance-trained men. Nutrition 18:734-737
    • (2002) Nutrition , vol.18 , pp. 734-737
    • van Gammeren, D.1    Falk, D.2    Antonio, J.3
  • 34
    • 0035005425 scopus 로고    scopus 로고
    • The effects of supplementation with 19-nor-4-androstene-3,17-dione and 19-nor-4-androstene-3, 17-diol on body composition and athletic performance in previously weight-trained male athletes
    • van Gammeren D, Falk D, Antonio J 2001 The effects of supplementation with 19-nor-4-androstene-3,17-dione and 19-nor-4-androstene-3, 17-diol on body composition and athletic performance in previously weight-trained male athletes. Eur J Appl Physiol 84:426-431
    • (2001) Eur J Appl Physiol , vol.84 , pp. 426-431
    • van Gammeren, D.1    Falk, D.2    Antonio, J.3
  • 35
    • 0035261654 scopus 로고    scopus 로고
    • The metabolism of orally ingested 19-nor-4-androstene-3,17-dione and 19-nor-4-androstene-3,17-diol in healthy, resistance-trained men
    • Colker CM, Antonio J, Kalman D 2001 The metabolism of orally ingested 19-nor-4-androstene-3,17-dione and 19-nor-4-androstene-3,17-diol in healthy, resistance-trained men. J Strength Cond Res 15:144-147
    • (2001) J Strength Cond Res , vol.15 , pp. 144-147
    • Colker, C.M.1    Antonio, J.2    Kalman, D.3
  • 36
    • 15244357835 scopus 로고    scopus 로고
    • Quantification and profiling of 19-norandrosterone and 19-noretiocholanolone in human urine after consumption of a nutritional supplement and norsteroids
    • Tseng YL, Kuo FH, Sun KH 2005 Quantification and profiling of 19-norandrosterone and 19-noretiocholanolone in human urine after consumption of a nutritional supplement and norsteroids. J Anal Toxicol 29:124-134
    • (2005) J Anal Toxicol , vol.29 , pp. 124-134
    • Tseng, Y.L.1    Kuo, F.H.2    Sun, K.H.3
  • 37
    • 33745936615 scopus 로고    scopus 로고
    • Detection and quantification of glucuro- and sulfoconjugated metabolites in human urine following oral administration of xenobiotic 19-norsteroids
    • Tseng YL, Sun CY, Kuo FH 2006 Detection and quantification of glucuro- and sulfoconjugated metabolites in human urine following oral administration of xenobiotic 19-norsteroids. Steroids 71:817-827
    • (2006) Steroids , vol.71 , pp. 817-827
    • Tseng, Y.L.1    Sun, C.Y.2    Kuo, F.H.3
  • 38
    • 0028854790 scopus 로고
    • Feedback regulation of gonadotropins by androgens in rats: Is 5α-reduction involved?
    • Kumar N, Sundaram K, Bardin CW 1995 Feedback regulation of gonadotropins by androgens in rats: is 5α-reduction involved? J Steroid Biochem Mol Biol 52:105-112
    • (1995) J Steroid Biochem Mol Biol , vol.52 , pp. 105-112
    • Kumar, N.1    Sundaram, K.2    Bardin, C.W.3
  • 39
    • 0037333156 scopus 로고    scopus 로고
    • Tibolone is not converted by human aromatase to 7α-methyl- 17α-ethynylestradiol (7α-MEE): Analyses with sensitive bioassays for estrogens and androgens and with LC-MSMS
    • de Gooyer ME, Oppers-Tiemissen HM, Leysen D, Verheul HA, Kloosterboer HJ 2003 Tibolone is not converted by human aromatase to 7α-methyl- 17α-ethynylestradiol (7α-MEE): analyses with sensitive bioassays for estrogens and androgens and with LC-MSMS. Steroids 68:235-243
    • (2003) Steroids , vol.68 , pp. 235-243
    • de Gooyer, M.E.1    Oppers-Tiemissen, H.M.2    Leysen, D.3    Verheul, H.A.4    Kloosterboer, H.J.5
  • 41
    • 4644304613 scopus 로고    scopus 로고
    • Kinase-mediated transcription, activators of nongenotropic estrogen-like signaling (ANGELS), and osteoporosis: A different perspective on the HRT dilemma
    • Manolagas SC, Kousteni S, Chen JR, Schuller M, Plotkin L, Bellido T 2004 Kinase-mediated transcription, activators of nongenotropic estrogen-like signaling (ANGELS), and osteoporosis: a different perspective on the HRT dilemma. Kidney Int Suppl 91:S41-S49
    • (2004) Kidney Int , Issue.SUPPL. 91
    • Manolagas, S.C.1    Kousteni, S.2    Chen, J.R.3    Schuller, M.4    Plotkin, L.5    Bellido, T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.