The pathophysiology of body dysmorphic disorder

Body Image

Volumn 5, Issue 1, 2008, Pages 3-12

  Feusner, Jamie D ^a   Yaryura Tobias, Jose ^b   Saxena, Sanjaya ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b BioBehavioral Institute Great Neck   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Body dysmorphic disorder; Neurobiology; Pathophysiology; Perception

Indexed keywords

ADULT; ARTICLE; BODY IMAGE; FRONTAL LOBE; HEMISPHERIC DOMINANCE; HUMAN; LIMBIC SYSTEM; MALE; NERVE CELL NETWORK; NUCLEAR MAGNETIC RESONANCE IMAGING; PARIETAL LOBE; PATHOPHYSIOLOGY; PHYSIOLOGY; SOMATOFORM DISORDER; TEMPORAL LOBE;

ADULT; BODY IMAGE; FRONTAL LOBE; FUNCTIONAL LATERALITY; HUMANS; LIMBIC SYSTEM; MAGNETIC RESONANCE IMAGING; MALE; NERVE NET; PARIETAL LOBE; SOMATOFORM DISORDERS; TEMPORAL LOBE;

EID: 41549084640     PISSN: 17401445     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bodyim.2007.11.002     Document Type: Article

References (78)

1. Adolphs R., Demasio H., Tranel D., and Demasio A. Cortical systems for the recognition of emotion in facial expressions. The Journal of Neuroscience 16 (1996) 7678-7687
2. American Psychiatric Association. Diagnostic and statistical manual of mental disorders: DSM-IV-TR. 4th ed. (2000), American Psychiatric Association, Washington, DC
3. Barr L., Goodman W., and Price L. Acute exacerbation of body dysmorphic disorder during tryptophan depletion. The American Journal of Psychiatry 149 (1992) 1406-1407
4. Barr L., Goodman W.K., and McDougle C. Tryptophan depletion in patients with obsessive-compulsive disorder who respond to serotonin reuptake inhibitors. Archives of General Psychiatry 51 (1994) 309-317
5. Bienvenu O., Samuels J., Riddle M., Hoehn-Saric R., Liang K., Cullen B., et al. The relationship of obsessive-compulsive disorder to possible spectrum disorders: Results from a family study. Biological Psychiatry 48 (2000) 287-293
6. Buhlmann U., Etcoff N., and Wilhelm S. Emotional recognition bias for contempt and anger in body dysmorphic disorder. Journal of Psychiatric Research 40 (2006) 105-111
7. Buhlmann U., McNally R., Etcoff N., Tuschen-Caffier B., and Wilhelm S. Emotion recognition deficits in body dysmorphic disorder. Journal of Psychiatric Research 38 (2004) 201-206
8. Buhlmann U., McNally R., Wilhelm S., and Florin I. Selective processing of emotional information in body dysmorphic disorder. Journal of Anxiety Disorders 16 (2002) 289-298
9. Buhlmann U., Wilhelm S., McNally R., Tuschen-Caffier B., Baer L., and Jenike M. Interpretive biases for ambiguous information in body dysmorphic disorder. CNS Spectrums 7 (2002) 435-443
10. Carey P., Seedat S., Warwick J., van Heerden B., and Stein D.J. SPECT imaging of body dysmorphic disorder. Journal of Neuropsychiatry and Clinical Neurosciences 16 (2004) 357-359
11. Craven J., and Rodin G. Cyproheptadine dependence associated with an atypical somatoform disorder. Canadian Journal of Psychiatry 32 (1987) 143-145
12. Deckersbach T., Savage C., Phillips K., Wilhelm S., Buhlmann U., Rauch S., et al. Characteristics of memory dysfunction in body dysmorphic disorder. Journal of the International Neuropsychological Society 6 (2000) 673-681
13. Devinsky O. Right cerebral hemisphere dominance for a sense of corporeal and emotional self. Epilepsy & Behavior 1 (2000) 60-73
14. Devinsky O., Khan S., and Alper K. Olfactory reference syndrome in a patient with partial epilepsy. Neuropsychiatry, Neuropsychology, and Behavioral Neurology 11 (1998) 103-105
15. Feusner, J., Bystritsky, A., & Bookheimer, S. (2006). Impaired processing of faces with emotional expressions in body dysmorphic disorder: Preliminary results. Paper presented at the 26th Annual Conference of the Anxiety Disorders Association of America Miami, FL.
16. Feusner, J., Townsend, J., Bystritsky, A., & Bookheimer, S. (2006). Visual information processing of faces in body dysmorphic disorder. Paper presented at the American College of Neuropsychopharmacology Annual Meeting, Hollywood, FL.
17. Frank G.K., Bailer U.F., Henry S., Wagner A., and Kaye W.H. Neuroimaging studies in eating disorders. CNS Spectrums 9 (2004) 539-548
18. Furmark T., Tillfors M., Marteinsdottir I., Fischer H., Pissiota A., Langstrom B., et al. Common changes in cerebral blood flow in patients with social phobia treated with citalopram or cognitive-behavioral therapy. Archives of General Psychiatry 59 (2002) 425-433
19. Gabbay V., Asnis G., Bello J., Alonso C., Serras S., and O'Dowd M. New onset of body dysmorphic disorder following frontotemporal lesion. Neurology 61 (2003) 123-125
20. Gabbay V., O'Dowd M., Weiss A., and Asnis G. Body dysmorphic disorder triggered by medical illness?. The American Journal of Psychiatry 159 (2002) 493
21. Grant J., Kim S., and Crow S. Prevalence and clinical features of body dysmorphic disorder in adolescent and adult psychiatric inpatients. Journal of Clinical Psychiatry 62 (2001) 517-522
22. Gur R., Skolnik B., and Gur R. Effects of emotional discrimination on cerebral blood flow: Regional activation and its relation to performance. Brain and Cognition 25 (1994) 271-286
23. Hadley S., Newcorn J., and Hollander E. The neurobiology and psychopharmacology of body dysmorphic disorder. In: Castle D., and Phillips K. (Eds). Disorders of body image (2002), Wrightson Biomedical Publishing Ltd, Petersfield, UK 139-155
24. Hanes K. Serotonin, psilocybin, and body dysmorphic disorder: A case report. Journal of Clinical Psychopharmacology 16 (1996) 188-189
25. Hanes K. Neuropsychological performance in body dysmorphic disorder. Journal of the International Neuropsychological Society 4 (1998) 167-171
26. Hay C. Dysmorphophobia. British Journal of Psychiatry 116 (1970) 399-406
27. Hollander E., Allen A., Kwon J., Aronowitz B., Schmeidler J., Wong C., et al. Clomipramine vs desipramine crossover trial in body dysmorphic disorder: Selective efficacy of a serotonin reuptake inhibitor in imagined ugliness. Archives of General Psychiatry 56 (1999) 1033-1039
28. Hollander E., and Wong C. Introduction: Obsessive-compulsive spectrum disorders. Journal of Clinical Psychiatry 56 (1995) 3-6
29. Kurosaki M., Shirao N., Yamashita H., Okamoto Y., and Yamawaki S. Distorted images of one's own body activates the prefrontal cortex and limbic/paralimbic system in young women: A functional magnetic resonance imaging study. Biological Psychiatry 59 (2006) 380-386
30. Mace C.J., and Trimble M.R. Psychosis following temporal lobe surgery: A report of six cases. Journal of Neurology, Neurosurgery, and Psychiatry 54 (1991) 639-644
31. Malloy P., and Richardson E. The frontal lobes and content-specific delusions. The Journal of Neuropsychiatry and Clinical Neurosciences 6 (1994) 455-466
32. Marazziti D., Dell'Osso L., and Presta S. Platelet [3H]paroxetine binding in patients with OCD-related disorders. Psychiatry Research 89 (1999) 223-228
33. Mathew S.J. PANDAS variant and body dysmorphic disorder. Americal Journal of Psychiatry 158 (2001) 963
34. Moreno F.A., and Delgado P.L. Hallucinogen-induced relief of obsessions and compulsions. Americal Journal of Psychiatry 154 (1997) 1037-1038
35. Murphy F.C., Nimmo-Smith I., and Lawrence A.D. Functional neuroanatomy of emotions: A meta-analysis. Cognitive, Affective and Behavioral Neuroscience 3 (2003) 207-233
36. Naga A., Devinsky O., and Barr W. Somatoform disorders after temporal lobectomy. Cognitive and Behavioral Neurology 17 (2004) 57-61
37. Perugi G., Giannotti D., Di Vaio S., Frare F., Saettoni M., and Cassano G.B. Fluvoxamine in the treatment of body dysmorphic disorder (dysmorphophobia). International Clinical Psychopharmacology 11 (1996) 247-254
38. Phelps E.A., Delgado M.R., Nearing K.I., and LeDoux J.E. Extinction learning in humans: Role of the amygdala and vmPFC. Neuron 43 (2004) 897-905
39. Phillips K.A. Quality of life for patients with body dysmorphic disorder. Journal of Nervous and Mental Disorders 188 (2000) 170-175
40. Phillips K.A., Albertini R.S., and Rasmussen S.A. A randomized placebo-controlled trial of fluoxetine in body dysmorphic disorder. Archives of General Psychiatry 59 (2002) 381-388
41. Phillips K.A., Dwight M.M., and McElroy S.L. Efficacy and safety of fluvoxamine in body dysmorphic disorder. Journal of Clinical Psychiatry 59 (1998) 165-171
42. Phillips K.A., Gunderson C.G., Mallya G., McElroy S.L., and Carter W. A comparison study of body dysmorphic disorder and obsessive-compulsive disorder. Journal of Clinical Psychiatry 59 (1998) 568-575
43. Phillips K.A., and Najjar F. An open-label study of citalopram in body dysmorphic disorder. Journal of Clinical Psychiatry 64 (2003) 715-720
44. Phillips K.A., Nierenberg A.A., Brendel G., and Fava M. Prevalence and clinical features of body dysmorphic disorder in atypical major depression. Journal of Nervous and Mental Disorders 184 (1996) 125-129
45. Price B.H., and Mesulam M. Psychiatric manifestations of right hemisphere infarctions. Journal of Nervous and Mental Disorders 173 (1985) 610-614
46. Rauch S.L., Phillips K.A., Segal E., Makris N., Shin L.M., Whalen P.J., et al. A preliminary morphometric magnetic resonance imaging study of regional brain volumes in body dysmorphic disorder. Psychiatry Research 122 (2003) 13-19
47. Richter, M., Tharmalingam, S., Burroughs, E., King, N., Menard, W., Kennedy, J., et al. (2004). A preliminary genetic investigation of the relationship between body dysmorphic disorder and OCD. Paper presented at the American College of Neuropsychopharmacology 2004 Annual Meeting, San Juan, Puerto Rico.
48. Rief W., Buhlmann U., Wilhelm S., Borkenhagen A., and Brahler E. The prevalence of body dysmorphic disorder: A population-based survey. Psychological Medicine 36 (2006) 877-885
49. Ruffolo J., Phillips K., Menard W., Fay C., and Weisberg R. Comorbidity of body dysmorphic disorder and eating disorders: Severity of psychopathology and body image disturbance. International Journal of Eating Disorders 39 (2006) 11-19
50. Salib E.A. Subacute sclerosing panencephalitis (SSPE) presenting at the age of 21 as a schizophrenia-like state with bizarre dysmorphophobic features. British Journal of Psychiatry 152 (1988) 709-710
51. Savage C., Deckersbach T., Wilhelm S., Rauch S., Baer L., Reid T., et al. Strategic processing and episodic memory impairment in obsessive-compulsive disorder. Neuropsychology 14 (2000) 141-151
52. Saxena S., Bota R., and Brody A. Brain-behavior relationships in obsessive-compulsive disorder. Seminars in Clinical Neuropsychiatry 6 (2001) 82-101
53. Saxena S., Brody A., Schwartz J., and Baxter L. Neuroimaging and frontal-subcortical circuitry in obsessive-compulsive disorder. British Journal of Psychiatry 173 (1998) 26-38
54. Saxena S., and Feusner J. Toward a neurobiology of body dysmorphic disorder. Primary Psychiatry 13 (2006) 41-48
55. Schienle A., Schafer A., Stark R., Walter B., and Vaitl D. Neural responses of OCD patients towards disorder-relevant, generally disgust-inducing and fear-inducing pictures. International Journal of Psychophysiology 57 (2005) 69-77
56. Shapira N.A., Liu Y., He A.G., Bradley M.M., Lessig M.C., James G.A., et al. Brain activation by disgust-inducing pictures in obsessive-compulsive disorder. Biological Psychiatry 54 (2003) 751-756
57. Sherman B., Savage C., Eddy K., Blais M., Deckersbach T., Jackson S., et al. Strategic memory in adults with anorexia nervosa: Are there similarities to obsessive compulsive spectrum disorders?. International Journal of Eating Disorders 39 (2006) 468-476
58. Shirao N., Okamoto Y., Mantani T., Okamoto Y., and Yamawaki S. Gender differences in brain activity generated by unpleasant word stimuli concerning body image: An fMRI study. British Journal of Psychiatry 186 (2005) 48-53
59. Shirao N., Okamoto Y., Okada G., Okamoto Y., and Yamawaki S. Temporomesial activation in young females associated with unpleasant words concerning body image. Neuropsychobiology 48 (2003) 136-142
60. Smeraldi E., Diaferia G., and Erzogovesi S. Tryptophan depletion in obsessive-compulsive patients. Biological Psychiatry 40 (1996) 398-402
61. Snider L.A., and Swedo S.E. PANDAS: Current status and directions for research. Molecular Psychiatry 9 (2004) 900-907
62. Sprengelmeyer R., Rausch M., Eysel U.T., and Przuntek H. Neural structures associated with recognition of facial expressions of basic emotions. Proceedings. Biological Sciences 265 (1998) 1927-1931
63. Stark R., Schienle A., Walter B., Kirsch P., Sammer G., Ott U., et al. Hemodynamic responses to fear and disgust-inducing pictures: An fMRI study. International Journal of Psychophysiology 50 (2003) 225-234
64. Stein M.B., Goldin P.R., Sareen J., Zorrilla L.T., and Brown G.G. Increased amygdala activation to angry and contemptuous faces in generalized social phobia. Archives of General Psychiatry 59 (2002) 1027-1034
65. Stevens J.R. Psychiatric consequences of temporal lobectomy for intractable seizures: A 20-30-year follow-up of 14 cases. Psychological Medicine 20 (1990) 529-545
66. Sugiura M., Watanabe J., Maeda Y., Matsue Y., Fukuda H., and Kawashima R. Cortical mechanisms of visual self-recognition. Neuroimage 24 (2005) 143-149
67. Trimble M.R. Body image and the temporal lobes. British Journal of Psychiatry Supplement (1988) 12-14
68. Uddin L., Kaplan J., Molnar-Szakacs I., Zaidel E., and Iacoboni M. Self-face recognition activates a frontoparietal "mirror" network in the right hemisphere: An event-related fMRI study. Neuroimage 25 (2005) 926-935
69. Uher R., Murphy T., Friederich H.C., Dalgleish T., Brammer M.J., Giampietro V., et al. Functional neuroanatomy of body shape perception in healthy and eating-disordered women. Biological Psychiatry 58 (2005) 990-997
70. Veale D. Body dysmorphic disorder. Postgraduate Medical Journal 80 (2004) 67-71
71. Veale D., Boocock A., Gournay K., Dryden W., Shah F., Willson R., et al. Body dysmorphic disorder. A survey of fifty cases. British Journal of Psychiatry 169 (1996) 196-201
72. Wagner A., Ruf M., Braus D.F., and Schmidt M.H. Neuronal activity changes and body image distortion in anorexia nervosa. Neuroreport 14 (2003) 2193-2197
73. Wilhelm S., Otto M.W., Zucker B.G., and Pollack M.H. Prevalence of body dysmorphic disorder in patients with anxiety disorders. Journal of Anxiety Disorders 11 (1997) 499-502
74. Wong F.C., Swartz B.E., Gee M., and Mandelkern M. Occipital hypometabolism demonstrated by positron emission tomography after temporal lobectomy for refractory epilepsy. Journal of Neuroophthalmology 24 (2004) 19-23
75. Wrench J., Wilson S.J., and Bladin P.F. Mood disturbance before and after seizure surgery: A comparison of temporal and extratemporal resections. Epilepsia 45 (2004) 534-543
76. Wright P., He G., Shapira N.A., Goodman W.K., and Liu Y. Disgust and the insula: fMRI responses to pictures of mutilation and contamination. Neuroreport 15 (2004) 2347-2351
77. Yaryura-Tobias J., Neziroglu F., Chang R., Lee S., Pinto A., and Donohue L. Computerized perceptual analysis of patients with body dysmorphic disorder. CNS Spectrums 7 (2002) 444-446
78. Yaryura-Tobias J., Neziroglu F., and Torres-Gallegos M. Neuroanatomical correlates and somatosensorial disturbances in body dysmorphic disorder. CNS Spectrums 7 (2002) 432-434