Toward a neurobiology of body dysmorphic disorder

Primary Psychiatry

Volumn 13, Issue 7, 2006, Pages 41-48

  Saxena, Sanjaya ^a,b,d   Feusner, Jamie D ^c  

^a Obsessive Compulsive Disorder Program   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYPROHEPTADINE; DESIPRAMINE; PSILOCYBINE; SEROTONIN; SEROTONIN TRANSPORTER; SEROTONIN UPTAKE INHIBITOR;

BODY DYSMORPHIC DISORDER; BODY IMAGE; BRAIN DAMAGE; COGNITIVE DEFECT; EMOTION; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HEREDITY; HUMAN; LIMBIC CORTEX; MEMORY; MODEL; NERVE CELL NETWORK; NEUROBIOLOGY; NEUROIMAGING; NEUROPSYCHOLOGY; OBSESSIVE COMPULSIVE DISORDER; PARIETAL LOBE; PSYCHOPHARMACOLOGY; REVIEW; SELF CONCEPT; SUBICULUM; TEMPORAL LOBE;

EID: 33746265898     PISSN: 10826319     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (78)

1. Diagnostic and Statistical Manual of Mental Disorders. 4th ed, text rev. Washington, DC: American Psychiatric Association; 2000.
2. Rief W, Buhlmann U, Wilhelm S, Borkenhagen A, Brahler E. The prevalence of body dysmorphic disorder: a population-based survey. Psychol Med. 2006;1-9.
3. Wilhelm S, Otto MW, Zucker BG, Pollack MH. Prevalence of body dysmorphic disorder in patients with anxiety disorders. J Anxiety Disord. 1997;11(5):499-502.
4. Grant JE, Kim SW, Crow SJ. Prevalence and clinical features of body dysmorphic disorder in adolescent and adult psychiatric inpatients. J Clin Psychiatry. 2001;62(7):517-522.
5. Phillips KA. Quality of life for patients with body dysmorphic disorder. J Nerv Ment Dis. 2000;188(3):170-175.
6. Phillips KA. Body dysmorphic disorder: the distress of imagined ugliness. Am J Psychiatry. 1991;148(9):1138-1149.
7. Pope HG Jr, Gruber W, Choi P, Olivardia R, Phillips KA. Muscle dysmorphia. An underrecognized form of body dysmorphic disorder. Psychosomatics. 1997;38(6):548-557.
8. Phillips KA, McElroy SL, Keck PE Jr, Hudson JI, Pope HG Jr. A comparison of delusional and nondelusional body dysmorphic disorder in 100 cases. Psychopharmacol Bull. 1994;30(2):179-186.
9. Phillips KA. The presentation of body dysmorphic disorder in medical settings. Primary Psychiatry. 2006;13(7):51-59.
10. Cororve MB, Cleaves DH. Body dysmorphic disorder: a review of conceptualizations, assessment, and treatment strategies. Clin Psychol Rev. 2001;21(6):949-970.
11. Hollander E. Obsessive compulsive spectrum disorders: an overview. Psychiatr Ann. 1993;23(7):355-358.
12. Gunstad J, Phillips KA. Axis I comorbidity in body dysmorphic disorder. Compr Psychiatry. 2003;44(4):270-276.
13. Bienvenu OJ, Samuels JF, Riddle MA, et al. The relationship of obsessive-compulsive disorder to possible spectrum disorders: results from a family study. Biol Psychiatry. 2000;48(4):287-293.
14. Phillips KA, Gunderson CG, Mallya G, McElroy SL, Carter W. A comparison study of body dysmorphic disorder and obsessive-compulsive disorder. J Clin Psychiatry. 1998;59(11):568-575.
15. Richter MA, Tharmalingam S, Burroughs E, et al. A preliminary genetic investigation of the relationship between body dysmorphic disorder and OCD. Heuropsychopharmacology. 2004;29(suppl 1):S200.
16. Marazziti D, Dell'Osso L, Presta S, et al. Platelet [3H]paroxetine binding in patients with OCD-related disorders. Psychiatry Res. 1999;89(3):223-228.
17. Barr LC, Goodman WK, Price LH. Acute exacerbation of body dysmorphic disorder during tryptophan depletion. Am J Psychiatry. 1992;149(10):1406-1407.
18. Barr LC, Goodman WK, McDougle CJ, et al. Tryptophan depletion in patients with obsessive-compulsive disorder who respond to serotonin reuptake inhibitors. Arch Gen Psychiatry. 1994;51(4):309-317.
19. Smeraldi E, Diaferia G, Erzegovesi S, Lucca A, Bellodi L, Moja EA. Tryptophan depletion in obsessive-compulsive patients. Biol Psychiatry. 1996;40(5):398-402.
20. Hanes KR. Serotonin, psilocybin, and body dysmorphic disorder: a case report. J Clin Psychopharmacol. 1996;16(2):188-189.
21. Moreno FA, Delgado PL. Hallucinogen-induced relief of obsessions and compulsions. Am J Psychiatry. 1997;154(7):1037-1038.
22. Craven JL, Rodin GM. Cyproheptadine dependence associated with an atypical somatoform disorder. Can J Psychiatry. 1987;32(2):143-145.
23. Phillips KA, Dwight MM, McElroy SL. Efficacy and safety of fluvoxamine in body dysmorphic disorder. J Clin Psychiatry. 1998;59(4):165-171.
24. Hollander E, Allen A, Kwon J, et al. Clomipramine vs desipramine crossover trial in body dysmorphic disorder: selective efficacy of a serotonin reuptake inhibitor in imagined ugliness. Arch Gen Psychiatry. 1999;56(11):1033-1039.
25. Phillips KA, Albertini RS, Rasmussen SA. A randomized placebo-controlled trial of fluoxetine in body dysmorphic disorder. Arch Gen Psychiatry. 2002;59(4):381-388.
26. Phillips KA, Najjar F. An open-label study of citalopram in body dysmorphic disorder. J Clin Psychiatry. 2003;64(6):715-720.
27. Hadley SJ, Kim S, Friday L. Pharmacologic treatment of body dysmorphic disorder. Primary Psychiatry. 2006;13(7):61-69.
28. Hanes KR. Neuropsychological performance in body dysmorphic disorder. J Int Neuropsychol Soc. 1998;4(2):167-171.
29. Deckersbach T, Savage CR, Phillips KA, et al. Characteristics of memory dysfunction in body dysmorphic disorder. J Int Neuropsychol Soc. 2000;6(6):673-681.
30. Savage CR, Deckersbach T, Wilhelm S, et al. Strategic processing and episodic memory impairment in obsessive compulsive disorder.Heuropsychology. 2000;14(1):141-151.
31. Buhlmann U, McNally RJ, Wilhelm S, Florin I. Selective processing of emotional information in body dysmorphic disorder. J Anxiety Disord. 2002;16(3):289-298.
32. Buhlmann U, Wilhelm S, McNally RJ, Tuschen-Caffier B, Baer L, Jenike MA. Interpretive biases for ambiguous information in body dysmorphic disorder. CNS Spectr. 2002;7(6):435-443.
33. Buhlmann U, McNally RJ, Etcoff NL, Tuschen-Caffier B, Wilhelm S. Emotion recognition deficits in body dysmorphic disorder. J Psychiatr Res. 2004;38(2):201-206.
34. Buhlmann U, Etcoff NL, Wilhelm S. Emotion recognition bias for contempt and anger in body dysmorphic disorder. J Psychiatr Res. 2006;40(2):105-111.
35. Feusner JD, Bystritsky A, Bookheimer S. Impaired processing of faces with emotional expressions in body dysmorphic disorder: preliminary results. Paper presented at: The 26th Annual Conference of the Anxiety Disorders Association of America; March 23-26, 2006; Miami, FL
36. Yaryura-Tobias JA, Neziroglu F, Torres-Gallegos M. Neuroanatomical correlates and somatosensorial disturbances in body dysmorphic disorder. CNS Spectr. 2002;7(6):432-434.
37. Thomas CS, Goldberg DP. Appearance, body image and distress in facial dysmorphophobia. Acta Psychiatr Scand. 1995;92(3):231-236.
38. Veale D. Body dysmorphic disorder. Postgrad Med J. 2004;80(940):67-71.
39. Gur RC, Skolnik BE, Gur RE. Effects of emotional discrimination tasks on cerebral blood flow: regional activation and its relation to performance. Brain Cogn. 1994;25(2):271-286.
40. Adolphs R, Damasio H, Tranel D, Damasio AR. Cortical systems for the recognition of emotion in facial expressions. J Neurosci. 1996;16(23):7678-7687.
41. Sprengelmeyer R, Rausch M, Eysel UT, Przuntek H. Neural structures associated with recognition of facial expressions of basic emotions. Proc Biol Sci. 1998;265(1409):1927-1931.
42. Stein MB, Goldin PR, Sareen J, Zorrilla LT, Brown GG. Increased amygdala activation to angry and contemptuous faces in generalized social phobia. Arch Gen Psychiatry. 2002;59(11):1027-1034.
43. Saxena S, Brody AL, Schwartz JM, Baxter LR. Neuroimaging and frontal-subcortical circuitry in obsessive-compulsive disorder. Br J Psychiatry Suppl. 1998;173(suppl 35):26-38.
44. Rauch SL, Phillips KA, Segal E, et al. A preliminary morphometric magnetic resonance imaging study of regional brain volumes in body dysmorphic disorder. Psychiatry Res. 2003;122(1):13-19.
45. Carey P, Seedat S, Warwick J, van Heerden B, Stein DJ. SPECT imaging of body dysmorphic disorder. J Neuropsychiatry Clin Neurosci. 2004;16(3):357-359.
46. Salib EA. Subacute sclerosing panencephalitis (SSPE) presenting at the age of 21 as a schizophrenia-like state with bizarre dysmorphophobic features. Br J Psychiatry. 1988;152:709-710.
47. Gabbay V, O'Dowd MA, Weiss W, Asnis GM. Body dysmorphic disorder triggered by medical illness? Am J Psychiatry. 2002;159(3):493.
48. Mathew SJ. PANDAS variant and body dysmorphic disorder. Am J Psychiatry. 2001;158(6):963.
49. Snider LA, Swedo SE. PANDAS: current status and directions for research. Mol Psychiatry. 2004;9(10):900-907.
50. Devinsky O, Khan S, Alper K. Olfactory reference syndrome in a patient with partial epilepsy. Neuropsychiatry Neuropsychol Behav Neurol. 1998;11(2):103-105.
51. Gabbay V, Asnis GM, Bello JA, Alonso CM, Serras SJ, O'Dowd MA. New onset of body dysmorphic disorder following frontotemporal lesion. Neurology. 2003;61(1):123-125.
52. Naga AA, Devinsky O, Barr WB. Somatoform disorders after temporal lobectomy. Cogn Behav Neurol. 2004;17(2):57-61.
53. Wong FC, Swartz BE, Gee M, Mandelkern M. Occipital hypometabolism demonstrated by positron emission tomography after temporal lobectomy for refractory epilepsy. J Neuroophthalmol. 2004;24(1):19-23.
54. Wrench J, Wilson SJ, Bladin PF. Mood disturbance before and after seizure surgery: a comparison of temporal and extratemporal resections. Epilepsia. 2004;45(5):534-543.
55. Stevens JR. Psychiatric consequences of temporal lobectomy for intractable seizures: a 20-30-year follow-up of 14 cases. Psychol Med. 1990;20(3):529-545.
56. Trimble MR. Body image and the temporal lobes. Br J Psychiatry Suppl. 1988;(2):12-14.
57. Shirao N, Okamoto Y, Mantani T, Okamoto Y, Yamawaki S. Gender differences in brain activity generated by unpleasant word stimuli concerning body image: an fMRI study. Br J Psychiatry. 2005;186:48-53.
58. Shirao N, Okamoto Y, Okada G, Okamoto Y, Yamawaki S. Temporomesial activation in young females associated with unpleasant words concerning body image. Neuropsychobiology. 2003;48(3):136-142.
59. Ruffolo JS, Phillips KA, Menard W, Fay C, Weisberg RB. Comorbidity of body dysmorphic disorder and eating disorders: severity of psychopathology and body image disturbance. Int J Eat Disord. 2006;39(1):11-19.
60. Sugiura M, Watanabe J, Maeda Y, Matsue Y, Fukuda H, Kawashima R. Cortical mechanisms of visual self-recognition. Neuroimage. 2005;24(1):143-149.
61. Uddin LQ, Kaplan JT, Molnar-Szakacs I, Zaidel E, Iacoboni M. Self-face recognition activates a frontoparietal "mirror" network in the right hemisphere: an event-related fMRI study. Neuroimage. 2005;25(3):926-935.
62. Wagner A, Ruf M, Braus DF, Schmidt MH. Neuronal activity changes and body image distortion in anorexia nervosa. Neuroreport. 2003;14(17):2193-2197.
63. Kurosaki M, Shirao N, Yamashita H, Okamoto Y, Yamawaki S. Distorted images of one's own body activates. the prefrontal cortex and limbic/paralimbic system in young women: a functional magnetic resonance imaging study. Biol Psychiatry. 2006;59(4):380-386.
64. Uher R, Murphy T, Friederich HC, et al. Functional neuroanatomy of body shape perception in healthy and eating-disordered women. Biol Psychiatry. 2005;58(12):990-997.
65. Frank GK, Bailer UF, Henry S, Wagner A, Kaye WH. Neuroimaging studies in eating disorders. CNS Spectr. 2004;9(7):539-548.
66. Murphy FC, Nimmo-Smith I, Lawrence AD. Functional neuroanatomy of emotions: a meta-analysis. Cogn Affect Behav Neurosci. 2003;3(3):207-233.
67. Wright P, He G, Shapira NA, Goodman WK, Liu Y. Disgust and the insula: fMRI responses to pictures of mutilation and contamination. Neuroreport. 2004;15(15):2347-2351.
68. Stark R, Schienle A, Walter B, et al. Hemodynamic responses to fear and disgust-inducing pictures: an fMRI study. Int J Psychophysiol. 2003;50(3):225-234.
69. Shapira NA, Liu Y, He AG, et al. Brain activation by disgust-inducing pictures in obsessive-compulsive disorder. Biol Psychiatry. 2003;54(7):751-756.
70. Schienle A, Schafer A, Stark R, Walter B, Vaitl D. Neural responses of OCD patients towards disorder-relevant, generally disgust-inducing and fear-inducing pictures. Int J Psychophysiol. 2005;57(1):69-77.
71. Devinsky O. Right cerebral hemisphere dominance for a sense of corporeal and emotional self. Epilepsy Behav. 2000;1(1):60-73.
72. Price BH, Mesulam M. Psychiatric manifestations of right hemisphere infarctions. J Nerv Ment Dis. 1985;173(10):610-614.
73. Malloy PF, Richardson ED. The frontal lobes and content-specific delusions. J Neuropsychiatric Clin Neurosci. 1994;6(4):455-466.
74. Murray EA, Bussey TJ, Hampton RR, Saksida LM. The parahippocampal region and object identification. Ann NY Acad Sci. 2000;911:166-174.
75. Pierrot-Deseilligny C, Muri RM, Rivaud-Pechoux S, Gaymard B, Ploner CJ. Cortical control of spatial memory in humans: the visuooculomotor model. Ann Neurol. 2002;52(1):10-19.
76. Medford N, Phillips ML, Brierley B, Brammer M, Bullmore ET, David AS. Emotional memory: separating content and context. Psychiatry Res. 2005;138(3):247-258.
77. Phelps EA, Delgado MR, Hearing KI, LeDoux JE. Extinction learning in humans: role of the amygdala and vmPFC. Neuron. 2004;43(6):897-905.
78. Furmark T, Tillfors M, Marteinsdottir I, et al. Common changes in cerebral blood flow in patients with social phobia treated with citalopram or cognitive-behavioral therapy. Arch Gen Psychiatry. 2002;59(5):425-433.