Simulation of the long-QT syndrome in a model of human myocardium

Computers in Cardiology

Volumn 30, Issue , 2003, Pages 287-290

  Seemann, Gunnar ^a   Weiss D L ^a   Sachse, F B ^b   Dossel O ^a  

^a UNIVERSITY OF KARLSRUHE   (Germany)

^b UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANISOTROPY; COMPUTER SIMULATION; DISEASES; DRUG PRODUCTS; GENES; PATHOLOGY; PHARMACODYNAMICS;

CHANNEL KINETICS; GENETIC DEFECTS; HUMAN MYOCARDIUM; LONG-QT SYNDROME;

ELECTROPHYSIOLOGY;

EID: 4143151959     PISSN: 02766574     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/cic.2003.1291147     Document Type: Conference Paper

References (10)

1. Antzelevitch C, Yan G, Shimizu W, Burashnikov A. Electrical heterogeneity, the EGG, and cardiac arrhythmias. In Zipes DP, Jalife J (eds.), Cardiac Electrophysiology. From Cell to Bedside, 3 edition. Philadelphia: W. B. Saunders Company. ISBN 0-7216-7811-4, 1999; 222-238.
2. Shimizu W, Antzelevitch C. Cellular basis for the ECG features of the LQT1 form of the long-QT syndrome: Effects of β-adrenergic agonists and antagonists and sodium channel blockers on transmural dispersion of repolarization and torsade de pointes. Circ 1998;98:2314-2322.
3. Shimizu W, Antzelevitch C. Sodium channel block with mexiletine is effective in reducing dispersion of repolarization and preventing torsade de pointes in LQT2 and LQT3 models of the long-QT syndrome. Circ 1997; 96:2038-2047.
4. Seemann G, Sachse FB, Weiß DL, Dössel O. Quantitative reconstruction of cardiac electro-mechanics in human myocardium: Regional heterogeneity. J Cardiovasc Electrophysiol 2003;14(Suppl.). In press.
5. Henriquez CS, Muzikant AL, Smoak CK. Anisotropy, fiber curvature and bath loading effects on activation in thin and thick cardiac tissue preparations: Simulations in a three-dimensional bidomain model. J Cardiovasc Electrophysiol May 1996;7(5):424-444.
6. Priebe L, Beuckelmann DJ. Simulation study of cellular electric properties in heart failure. Circ Res 1998;82:1206-1223.
7. Viswanathan P, Rudy Y. Cellular arrhythmogenic effects of congenital and acquired long-QT syndrome in the heterogeneous myocardium. Circ 2000;101:1192-1198.
8. + channel mutation that causes both brugada and long-QT syndrome phenotypes. Circ 2002; 105:1208-1213.
9. Streeter DD. Gross morphology and fiber geometry of the heart. In Bethesda B (ed.), Handbook of Physiology: The Cardiovascular System, volume I. American Physiology Society, 1979; 61-112.
10. Gima K, Rudy Y. Ionic current basis of electrocardiographic waveforms - A model study. Circ Res 2002;90:889-896.