Bcl-2 overexpression does not promote axonal regeneration of the entorhino-hippocampal connections in vitro after axotomy

Brain Research

Volumn 1020, Issue 1-2, 2004, Pages 204-209

  Solé, Marta ^a   Fontana, Xavier ^a   Gavín, Rosalina ^a   Soriano, Eduardo ^a   Del Río, José Antonio ^a  

^a Devmt and Regeneration of the CNS   (Spain)

Author keywords

Cell death; Development and regeneration; Glial scar; Organotypic slice coculture; Perforant path lesion; Regeneration

Indexed keywords

ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL DEATH; COCULTURE; CONTROLLED STUDY; ENTORHINAL CORTEX; HIPPOCAMPUS; IN VITRO STUDY; MOUSE; NERVE CELL; NERVE FIBER REGENERATION; NERVE FIBER TRANSECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TISSUE CULTURE;

ANIMALS; AXONS; AXOTOMY; CELL DEATH; CELL SURVIVAL; COCULTURE TECHNIQUES; CYCLIN D1; ENTORHINAL CORTEX; GROWTH CONES; HIPPOCAMPUS; MICE; MICE, INBRED STRAINS; MICE, TRANSGENIC; NERVE REGENERATION; ORGAN CULTURE TECHNIQUES; PERFORANT PATHWAY;

EID: 4143116683     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2004.05.107     Document Type: Article

References (36)

1. Alcantara S., Frisen J., del Rio J.A., Soriano E., Barbacid M., Silos-Santiago I. TrkB signaling is required for postnatal survival of CNS neurons and protects hippocampal and motor neurons from axotomy-induced cell death. J. Neurosci. 17:1997;3623-3633
2. Allsopp T.E., Wyatt S., Paterson H.F., Davies A.M. The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis. Cell. 73:1993;295-307
3. Amaral D.G., Witter M.P. Hippocampal formation. Paxinos G. The Rat Nervous System. 1995;443-493 Academic Press, San Diego
4. Bonfanti L., Strettoi E., Chierzi S., Cenni M.C., Liu X.H., Martinou J.C., Maffei L., Rabacchi S.A. Protection of retinal ganglion cells from natural and axotomy-induced cell death in neonatal transgenic mice overexpressing bcl-2. J. Neurosci. 16:1996;4186-4194
5. Caleo M., Cenni M.C., Costa M., Menna E., Zentilin L., Giadrossi S., Giacca M., Maffei L. Expression of BCL-2 via adeno-associated virus vectors rescues thalamic neurons after visual cortex lesion in the adult rat. Eur. J. Neurosci. 15:2002;1271-1277
6. Cenni M.C., Bonfanti L., Martinou J.C., Ratto G.M., Strettoi E., Maffei L. Long-term survival of retinal ganglion cells following optic nerve section in adult bcl-2 transgenic mice. Eur. J. Neurosci. 8:1996;1735-1745
7. Chen D.F., Schneider G.E., Martinou J.C., Tonegawa S. Bcl-2 promotes regeneration of severed axons in mammalian CNS. Nature. 385:1997;434-439
8. Chierzi S., Strettoi E., Cenni M.C., Maffei L. Optic nerve crush: axonal responses in wild-type and bcl-2 transgenic mice. J. Neurosci. 19:1999;8367-8376
9. Clark R.S., Chen J., Watkins S.C., Kochanek P.M., Chen M., Stetler R.A., Loeffert J.E., Graham S.H. Apoptosis-suppressor gene bcl-2 expression after traumatic brain injury in rats. J. Neurosci. 17:1997;9172-9182
10. Deckwerth T.L., Elliott J.L., Knudson C.M., Johnson E.M., Snider W.D., Korsmeyer S.J. BAX is required for neuronal death after trophic factor deprivation and during development. Neuron. 17:1996;401-411
11. Deller T., Frotscher M. Lesion-induced plasticity of central neurons: sprouting of single fibres in the rat hippocampus after unilateral entorhinal cortex lesion. Prog. Neurobiol. 53:1997;687-727
12. Del Rio J.A., Heimrich B., Borrell V., Forster E., Drakew A., Alcantara S., Nakajima K., Miyata T., Ogawa M., Mikoshiba K., Derer P., Frotscher M., Soriano E. A role for Cajal-Retzius cells and reelin in the development of hippocampal connections. Nature. 385:1997;70-74
13. Del Rio J.A., Sole M., Borrell V., Martinez A., Soriano E. Involvement of Cajal-Retzius cells in robust and layer-specific regeneration of the entorhino-hippocampal pathways. Eur. J. Neurosci. 15:2002;1881-1890
14. Eyüpoglu I.Y., Svaskan N.E., Bräuer A.U., Nitsch R., Heirmich B. Identification of neuronal cell death in a model of degeneration in the hippocampus. Brain Res. Protoc. 11:2003;1-8
15. Goldberg J.L., Barres B.A. The relationship between neuronal survival and regeneration. Annu. Rev. Neurosci. 23:2000;579-612
16. Goldberg J.L., Espinosa J.S., Xu Y., Davidson N., Kovacs G.T., Barres B.A. Retinal ganglion cells do not extend axons by default: promotion by neurotrophic signaling and electrical activity. Neuron. 33:2002;689-702
17. Holm K., Isacson O. Factors intrinsic to the neuron can induce and maintain its ability to promote axonal outgrowth: a role for BCL2? Trends Neurosci. 22:1999;269-273
18. Horner P.J., Gage F.H. Regenerating the damaged central nervous system. Nature. 407:2000;963-970
19. Inoue T., Hosokawa M., Morigiwa K., Ohashi Y., Fukuda Y. Bcl-2 overexpression does not enhance in vivo axonal regeneration of retinal ganglion cells after peripheral nerve transplantation in adult mice. J. Neurosci. 22:2002;4468-4477
20. Kluck R.M., Bossy-Wetzel E., Green D.R., Newmeyer D.D. The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science. 275:1997;1132-1136
21. Kotulska K., Lewin-Kowalik J., Larysz-Brysz M., Marcol W., Fus Z. Bcl-2 deficiency deprives peripheral nerves of neurotrophic activity against injured optic nerve. J. Neurosci. Res. 73:2003;846-852
22. Li D., Field P., Raisman G. Failure of axon regeneration in postnatal rat entorhinohippocampal slice coculture is due to maturation of the axon, not that of the pathway or target. Eur. J. Neurosci. 7:1995;1164-1171
23. Lindsay R.M. Nerve growth factors (NGF, BDNF) enhance axonal regeneration but are not required for survival of adult sensory neurons. J. Neurosci. 8:1988;2394-2405
24. Lodovichi C., Di Cristo G., Cenni M.C., Maffei L. Bcl-2 overexpression per se does not promote regeneration of neonatal crushed optic fibers. Eur. J. Neurosci. 13:2001;833-838
25. Martinou J.C., Dubois-Dauphin M., Staple J.K., Rodriguez I., Frankowski H., Missotten M., Albertini P., Talabot D., Catsicas S., Pietra C., et al. Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia. Neuron. 13:1994;1017-1030
26. McDonnell T.J., Deane N., Platt F.M., Nunez G., Jaeger U., McKearn J.P., Korsmeyer S.J. bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation. Cell. 57:1989;79-88
27. Mingorance A., Fontana X., Solé M., Burgaya F., Ureña J.M., Teng F.Y.H., Tang B.L., Hunt D., Anderson P.N., Bethea J.R., Schwab M., Soriano E., del Río J.A. Regulation of Nogo and Nogo receptor during the development of the entorhino-hippocampal pathway and after adult hippocampal lesions. Mol. Cell. Neurosci. 26:2004;34-49
28. Oh Y.J., Swarzenski B.C., O'Malley K.L. Overexpression of Bcl-2 in a murine dopaminergic neuronal cell line leads to neurite outgrowth. Neurosci. Lett. 202:1996;161-164
29. Oltvai Z.N., Milliman C.L., Korsmeyer S.J. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell. 74:1993;609-619
30. Peterson D.A., Lucidi-Phillipi C.A., Eagle K.L., Gage F.H. Perforant path damage results in progressive neuronal death and somal atrophy in layer II of entorhinal cortex and functional impairment with increasing postdamage age. J. Neurosci. 14:1994;6872-6885
31. Peterson D.A., Lucidi-Phillipi C.A., Murphy D.P., Ray J., Gage F.H. Fibroblast growth factor-2 protects entorhinal layer II glutamatergic neurons from axotomy-induced death. J. Neurosci. 16:1996;886-898
32. Prang P., Del Turco D., Kapfhammer J.P. Regeneration of entorhinal fibers in mouse slice cultures is age dependent and can be stimulated by NT-4, GDNF, and modulators of G-proteins and protein kinase C. Exp. Neurol. 169:2001;135-147
33. Schwab M.E., Bartholdi D. Degeneration and regeneration of axons in the lesioned spinal cord. Physiol. Rev. 76:1996;319-370
34. Stoppini L., Buchs P.A., Muller D. A simple method for organotypic cultures of nervous tissue. J. Neurosci. Methods. 37:1991;173-182
35. Woodhams P.L., Atkinson D.J. Regeneration of entorhino-dentate projections in organotypic slice cultures: mode of axonal regrowth and effects of growth factors. Exp. Neurol. 140:1996;68-78
36. Zhong L.T., Sarafian T., Kane D.J., Charles A.C., Mah S.P., Edwards R.H., Bredesen D.E. bcl-2 inhibits death of central neural cells induced by multiple agents. Proc. Natl. Acad. Sci. U. S. A. 90:1993;4533-4537