Mechanism of internal anal sphincter relaxation by CORM-1, authentic CO, and NANC nerve stimulation

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 287, Issue 3 50-3, 2004, Pages

  Rattan, Satish ^a   Al Haj, Rany ^a   De Godoy, Márcio A F ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Guanylate cyclase; Heme oxygenase; Inhibitory neurotransmitter; Nitric oxide synthase; Smooth muscle

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; CARBON MONOXIDE; CARBON MONOXIDE RELEASING MOLECULE 1; CYCLIC GMP; GUANYLATE CYCLASE; GUANYLATE CYCLASE INHIBITOR; HEMATIN; HEME OXYGENASE 1; HEME OXYGENASE 2; HEME OXYGENASE INHIBITOR; N(G) NITROARGININE; NEUROTOXIN; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; PROTEIN KINASE; PROTOPORPHYRIN TIN; RUTHENIUM DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANUS SPHINCTER; ARTICLE; CONTROLLED STUDY; ELECTROSTIMULATION; MALE; NERVE STIMULATION; NONADRENERGIC NONCHOLINERGIC NERVE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; TREATMENT OUTCOME; WESTERN BLOTTING;

ANAL CANAL; ANIMALS; AUTONOMIC NERVOUS SYSTEM; BLOTTING, WESTERN; CARBON MONOXIDE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; ENZYME INHIBITORS; GUANYLATE CYCLASE; HEME OXYGENASE (DECYCLIZING); HEMIN; ISOMETRIC CONTRACTION; MALE; MUSCLE RELAXATION; MUSCLE TONUS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; NITROARGININE; PROTOPORPHYRINS; RATS; RATS, SPRAGUE-DAWLEY; TETRODOTOXIN;

EID: 4143091446     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.00070.2004     Document Type: Article

References (43)

1. Biancani P, Walsh JH, and Behar J. Vasoactive intestinal polypeptide: a neurotransmitter for relaxation of the rabbit internal anal sphincter. Gastroenterology 89: 867-874, 1985.
2. Boehning D, Moon C, Sharma S, Hurt KJ, Hester LD, Ronnett GV, Shugar D, and Snyder SH. Carbon monoxide neurotransmission activated by CK2 phosphorylation of heme oxygenase-2. Neuron 40: 129-137, 2003.
3. Boehning D and Snyder SH. Novel neural modulators. Annu Rev Neurosci 26: 105-131, 2003.
4. g-nitro-L-arginine reduces nonadrenergic, noncholinergic relaxations of human gut. Gastroenterology 102: 679-683, 1992.
5. 2a-induced contraction of cat esophageal and lower esophageal sphincter circular smooth muscle. Am J Physiol Gastrointest Liver Physiol 283: G282-G291, 2002.
6. Gary SPL and Marietta MA. The case of CO signaling: why the jury is still out? J Clin Invest 107: 1071-1073, 2001.
7. Chakder S, Bandyopadhyay A, and Rattan S. Neuronal NOS gene expression in gastrointestinal myenteric neurons and smooth muscle cells. Am J Physiol Cell Physiol 273: C1868-C1875, 1997.
8. Ghakder S, Cao GY, Lynn RB, and Rattan S. Heme oxygenase activity in the internal anal sphincter: effects of nonadrenergic, noncholinergic nerve stimulation. Gastroenterology 118: 477-486, 2000.
9. Chakder S, Rathi S, Ma X, and Rattan S. Heme oxygenase inhibitor zinc protoporphyrin IX causes an activation of nitric oxide synthase in the rabbit internal anal sphincter. J Pharmacol Exp Ther 277: 1376-1382, 1996.
10. Chen Y, Lui VCH, Sham MH, and Tam PKH. Distribution of carbon monoxide-producing neurons in human colon and in Hirschsprung's disease patients. Hum Pathol 33: 1030-1036, 2002.
11. Colpaert EE, Timmermans JP, and Lefebvre RA. Investigation of the potential modulatory effect of biliverdin, carbon monoxide and bilirubin on nitrergic neurotransmission in the pig gastric fundus. Eur J Pharmacol 457: 177-186, 2002.
12. Fan YP, Chakder S, Gao F, and Rattan S. Inducible and neuronal nitric oxide synthase involvement in lipopolysaccharide-induced sphincteric dysfunction. Am J Physiol Gastrointest Liver Physiol 280: G32-G42, 2001.
13. Fan YP, Puri RN, and Rattan S. Animal model for angiotensin II effects in the internal anal sphincter smooth muscle: mechanism of action. Am J Physiol Gastrointest Liver Physiol 282: G461-G469, 2002.
14. Farrugia G, Irons WA, Rae JL, Sarr MG, and Szurszewski JH. Activation of whole cell currents in isolated human jejunal circular smooth muscle cells by carbon monoxide. Am J Physiol Gastrointest Liver Physiol 264: G1184-G1189, 1993.
15. Farrugia G, Lei S, Lin X, Miller SM, Nath KA, Ferris CD, Levitt M, and Szurszewski JH. A major role for carbon monoxide as an endogenous hyperpolarizing factor in the gastrointestinal tract. Proc Natl Acad Sci USA 100: 8567-8570, 2003.
16. Goyal RK, Rattan S, and Said SI. VIP as a possible neurotransmitter of non-cholinergic non-adrenergic inhibitory neurones. Nature 288: 378-380, 1980.
17. Lamar CA, Mahesh VB, and Brann DW. Regulation of gonadotropin-releasing hormone (GnRH) secretion by heme molecules: a regulatory role for carbon monoxide? Endocrinology 137: 790-793, 1996.
18. Lefebvre RA. Nitric oxide in the peripheral nervous system. Ann Med 27: 379-388, 1995.
19. Lowry OH, Rosebrough NJ, Fair AL, and Randall RJ. Protein measurements with the Folin phenol reagent. J Biol Chem 193: 265-275, 1951.
20. Maines MD. Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications. FASEB J 2: 2557-2568, 1988.
21. Maines MD. The heme oxygenase system: a regulator of second messenger gases. Annu Rev Pharmacol Toxicol 37: 517-554, 1997.
22. Miller SM, Farrugia G, Schmalz PF, Ermilov LG, Maines MD, and Szurszewski JH. Heme oxygenase 2 is present in interstitial cell networks of the mouse small intestine. Gastroenterology 114: 239-244, 1998.
23. Miller SM, Reed D, Sarr MG, Farrugia G, and Szurszewski JH. Haem oxygenase in enteric nervous system of human stomach and jejunum and co-localization with nitric oxide synthase. Neurogastroenterol Motil 13: 121-131, 2001.
24. Motterlini R, Clark JE, Foresti R, Sarathchandra P, Mann BE, and Green CJ. Carbon monoxide-releasing molecules: characterization of biochemical and vascular activities. Circ Res 90: E17-E24, 2002.
25. Moummi C and Rattan S. Effect of methylene blue and W-ethylmaleimide on internal anal sphincter relaxation. Am J Physiol Castrointest Liver Physiol 255: G571-G578, 1988.
26. Ny L, Aim P, Ekstrom P, Larsson B, Grundemar L, and Andersson KE. Localization and activity of haem oxygenase and functional effects of carbon monoxide in the feline lower oesophageal sphincter. Br J Pharmacol 118: 392-399, 1996.
27. Ny L, Alm P, Larsson B, and Andersson KE. Morphological relations between haem oxygenases, NO-synthase and VIP in the canine and feline gastrointestinal tracts. J Auton Nerv Syst 65; 49-56, 1997.
28. O'Kelly T, Brading A, and Mortensen N. Nerve-mediated relaxation of the human internal anal sphincter: The role of nitric oxide. Gut 34: 689-693, 1993.
29. O'Kelly TJ, Davies JR, Brading AF, and Mortensen NJMC. Distribution of nitric oxide synthase containing neurons in the rectal myenteric plexus and anal canal. Dis Colon Rectum 352: 350-357, 1994.
30. Rattan S. The non-adrenergic non-cholinergic innervation of the esophagus and the lower esophageal sphincter. Arch Int Pharmacodyn 280: 62-83, 1986.
31. Rattan S and Chakder S. Influence of heme oxygenase inhibitors on the basal tissue enzymatic activity and smooth muscle relaxation of internal anal sphincter. J Pharmacol Exp Ther 294: 1009-1016, 2000.
32. Rattan S and Chakder S. Role of nitric oxide as a mediator of internal anal sphincter relaxation. Am J Physiol Castrointest Liver Physiol 262: G107-G112, 1992.
33. Rattan S and Chakder S. Inhibitory effect of CO on internal anal sphincter: heme oxygenase inhibitor inhibits NANC relaxation. Am J Physiol Gastrointest Liver Physiol 265: G799-G804, 1993.
34. Rattan S, Sarkar A, and Chakder S. Nitric oxide pathway in rectoanal inhibitory reflex of opossum internal anal sphincter. Gastroenterology 103: 43-50, 1992.
35. Schröder A, Hedlund P, and Andersson ICE. Carbon monoxide relaxes the female pig urethra as effectively as nitric oxide in the presence of YC-1. J Urol 167: 1892-1896, 2002.
36. Seki T, Naruse M, Naruse K, Yoshimoto T, Tanabe A, Imaki T, Hagiwara H, Hirose S, and Demura H. Interrelation between nitric oxide synthase and heme oxygenase in rat endothelial cells. Eur J Pharmacol 331: 87-91, 1997.
37. Stark ME and Szurszewski JH. Role of nitric oxide in gastrointestinal and hepatic function and disease. Gastroenterology 103: 1928-1949, 1992.
38. Thorup C, Jones CL, Gross SS, Moore LC, and Goligorsky MS. Carbon monoxide induces vasodilation and nitric oxide release but suppresses endothelial NOS. Am J Physiol Renal Physiol 277: F882-F889, 1999.
39. Vanderwinden JM, De Laet MH, Schiffmann SN, Mailleux P, Lowenstein CJ, Snyder SH, and Vanderhaeghen JJ. Nitric oxide synthase distribution in the enteric nervous system of Hirschsprung's disease. Gastroenterology 105: 969-973, 1993.
40. Vinograd I, Hanani M, Hadary A, Merguerian P, and Nissan S. Animal model for the study of internal anal sphincter activity. Eur Surg Res 17: 259-263, 1985.
41. Watkins CC, Boehning D, Kaplin AI, Rao M, Ferris CD, and Snyder SH. Carbon monoxide mediates vasoactive intestinal polypeptide-associated nonadrenergic/noncholinergic neurotransmission. Proc Natl Acad Sci USA 101: 2631-2635, 2004.
42. Werkström V, Ny L, Persson K, and Andersson KE. Carbon monoxide-induced relaxation and distribution of haem oxygenase isoenzymes in the pig urethra and lower oesophagogastric junction. Br J Pharmacol 120: 312-318, 1997.
43. Zakhary R, Poss KD, Jaffrey SR, Ferris CD, Tonegawa S, and Snyder SH. Targeted gene deletion of heme oxygenase 2 reveals neural role for carbon monoxide. Proc Natl Acad Sci USA 94: 14848-14853, 1997.