Angiogenic and cardiac functional effects of dual gene transfer of VEGF-A 165 and PDGF-BB after myocardial infarction

Biochemical and Biophysical Research Communications

Volumn 322, Issue 1, 2004, Pages 292-296

  Hao, Xiaojin ^a   Månsson Broberg, Agneta ^a   Blomberg, Pontus ^b   Dellgren, Göran ^b   Siddiqui, Anwar J ^a   Grinnemo, Karl Henrik ^b   Wärdell, Eva ^a   Sylvén, Christer ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Angiogenesis; Arteriogenesis; Myocardial infarction; PDGF BB; Plasmid; VEGF A 165

Indexed keywords

NAKED DNA; RECOMBINANT PLATELET DERIVED GROWTH FACTOR BB; RECOMBINANT VASCULOTROPIN; RECOMBINANT VASCULOTROPIN A 165; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CAPILLARY DENSITY; COMPARATIVE STUDY; CONTRAST ECHOCARDIOGRAPHY; CONTROLLED STUDY; CORONARY ARTERY LIGATION; DRUG INFUSION; GENE REPLACEMENT THERAPY; GENE TRANSFER; HEART ATRIUM FUNCTION; HEART LEFT VENTRICLE HYPERTROPHY; HEART MUSCLE CAPILLARY; HEART MUSCLE ISCHEMIA; HEART VENTRICLE FUNCTION; LEFT ANTERIOR DESCENDING CORONARY ARTERY; NONHUMAN; PRIORITY JOURNAL; RAT; RECOMBINANT PLASMID;

ANIMALS; CORONARY VESSELS; GENE EXPRESSION REGULATION; GENE TRANSFER TECHNIQUES; MYOCARDIAL ISCHEMIA; NEOVASCULARIZATION, PHYSIOLOGIC; PLASMIDS; PLATELET-DERIVED GROWTH FACTOR; RATS; RATS, SPRAGUE-DAWLEY; TREATMENT OUTCOME; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 4143076904     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.07.101     Document Type: Article

References (18)

1. S. Yla-Herttuala, and K. Alitalo Gene transfer as a tool to induce therapeutic vascular growth Nat. Med. 9 2003 694 701
2. N. Ferrara Role of vascular endothelial growth factor in regulation of physiological angiogenesis Am. J. Physiol. Cell. Physiol. 280 2001 C1358 C1366
3. C. Patterson, and M.S. Runge Therapeutic myocardial angiogenesis via vascular endothelial growth factor gene therapy: moving on down the road Circulation 102 2000 940 942
4. C.H. Heldin, and B. Westermark Mechanism of action and in vivo role of platelet-derived growth factor Physiol. Rev. 79 1999 1283 1316
5. P. Lindahl, H. Bostrom, L. Karlsson, M. Hellstrom, M. Kalen, and C. Betsholtz Role of platelet-derived growth factors in angiogenesis and alveogenesis Curr. Top. Pathol. 93 1999 27 33
6. G.D. Yancopoulos, S. Davis, N.W. Gale, J.S. Rudge, S.J. Wiegand, and J. Holash Vascular-specific growth factors and blood vessel formation Nature 407 2000 242 248
7. D.C. Darland, and P.A. D'Amore Blood vessel maturation: vascular development comes of age J. Clin. Invest. 103 1999 157 158
8. L.E. Benjamin, I. Hemo, and E. Keshet A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF Development 125 1998 1591 1598
9. T.P. Richardson, M.C. Peters, A.B. Ennett, and D.J. Mooney Polymeric system for dual growth factor delivery Nat. Biotechnol. 19 2001 1029 1034
10. K. Li, R.E. Welikson, K.L. Vikstrom, and L.A. Leinwand Direct gene transfer into the mouse heart J. Mol. Cell. Cardiol. 29 1997 1499 1504
11. P.M. Buttrick, A. Kass, R.N. Kitsis, M.L. Kaplan, and L.A. Leinwand Behavior of genes directly injected into the rat heart in vivo Circ. Res. 70 1992 193 198
12. M. Lee, J. Rentz, S.O. Han, D.A. Bull, and S.W. Kim Water-soluble lipopolymer as an efficient carrier for gene delivery to myocardium Gene Ther. 10 2003 585 593
13. Y. Tsurumi, S. Takeshita, D. Chen, M. Kearney, S.T. Rossow, J. Passeri, J.R. Horowitz, J.F. Symes, and J.M. Isner Direct intramuscular gene transfer of naked DNA encoding vascular endothelial growth factor augments collateral development and tissue perfusion Circulation 94 1996 3281 3290
14. N. Ferrara, H.P. Gerber, and J. LeCouter The biology of VEGF and its receptors Nat. Med. 9 2003 669 676
15. N. Sarkar, P. Blomberg, E. Wardell, M. Eskandarpour, C. Sylvén, V. Drvota, and K.B. Islam Nonsurgical direct delivery of plasmid DNA into rat heart: time course, dose response, and the influence of different promoters on gene expression J. Cardiovasc. Pharmacol. 39 2002 215 224
16. A.H. Dorafshar, N. Angle, M. Bryer-Ash, D. Huang, M.M. Farooq, H.A. Gelabert, and J.A. Freischlag Vascular endothelial growth factor inhibits mitogen-induced vascular smooth muscle cell proliferation J. Surg. Res. 114 2003 179 186
17. X. Hao, A. Mansson-Broberg, T. Gustafsson, K.H. Grinnemo, P. Blomberg, A.J. Siddiqui, E. Wardell, and C. Sylvén Angiogenic effects of dual gene transfer of bFGF and PDGF-BB after myocardial infarction Biochem. Biophys. Res. Commun. 315 2004 1058 1063
18. M. Pfeffer, and E. Braunwald Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications Circulation 81 1990 1161 1172