Contractile effects of neuropeptide Y in human subcutaneous resistance arteries are mediated by Y1 receptors

Journal of Cardiovascular Pharmacology

Volumn 28, Issue 6, 1996, Pages 764-768

  Nilsson, Torun ^a   Erlinge, David ^a   Cantera, Leonor ^a   Edvinsson, Lars ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

BIBP3226; Human; Neuropeptide Y; Polymerase chain reaction; Resistance arteries; Reverse transcriptase

Indexed keywords

NEUROPEPTIDE Y; NEUROPEPTIDE Y DERIVATIVE; NEUROPEPTIDE Y1 RECEPTOR;

ARTERY CONSTRICTION; ARTICLE; DRUG EFFECT; DRUG RECEPTOR BINDING; HUMAN; HUMAN TISSUE; HYPERTENSION; PRIORITY JOURNAL; RESISTANCE BLOOD VESSEL;

ARGININE; ARTERIES; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; NEUROPEPTIDE Y; POLYMERASE CHAIN REACTION; RECEPTORS, NEUROPEPTIDE Y; RNA, MESSENGER; VASOCONSTRICTION;

EID: 0029850602     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199612000-00005     Document Type: Article

References (24)

1. Edvinsson L, Håkanson R, Wahlestedt C, Uddman R. Effects of neuropeptide Y on the cardiovascular system. Trends Pharmacol Sci 1987;8:231-5.
2. Edvinsson L. Håkanson R, Steen S, Sundler F, Uddman R, Wahlestedt C. Innervation of human omental arteries and veins and vasomotor responses to noradrenaline, neuropeptide Y, substance P and vasoactive intestinal peptide. Regul Pept 1985;12:67-79.
3. Pernow J, Lundberg JM, Kaijser L. Vasoconstrictor effects in vivo and plasma disappearance rate of neuropeptide Y in man. Life Sci 1987;40:47-54.
4. Zukowska-Grojec Z, Marks ES, Haass M. Neuropeptide Y is a potent vasoconstrictor and cardiac depressant in rat. Am J Physiol 1987;253:H1234-9.
5. Edvinsson L, Erlinge D, Sun XY, Hedner T. Neuropeptide Y in sympathetic co-transmission: recent advances in the search for neuropeptide Y antagonists. Pharmacol Toxicol 1994;74:193-201.
6. Wahlestedt C, Reis DJ. Neuropeptide Y-related peptides and their receptors - are the receptors potential therapeutic drug targets? Annu Rev Pharmacol Toxicol 1993;32:309-52.
7. Grundemar L, Mörner J, Högestätt E, Wahlestedt C, Håkanson R. Characterization of vascular receptors for neuropeptide Y. Br J Pharmacol 1992;105:45-50.
8. Modin A, Pernow J, Lundberg J. Evidence for two neuropeptide Y receptors mediating vasoconstriction. Eur J Pharmacol 1991;203:165-71.
9. 1 receptor antisense oligodeoxynucleotide specifically inhibits neuropeptide Y-evoked vasoconstriction. Eur J Pharmacol 1993;240:77-80.
10. Erlinge D. The sympathetic cotransmitters neuropeptide Y and ATP in the regulation of the vascular smooth muscle cell. Thesis. University of Lund, Lund, Sweden, 1994.
11. Herzog H, Hort YJ, Ball HJ, Hayes G, Shine J, Selbie LA. Cloned human neuropeptide Y receptor couples to two different second messenger systems. Proc Natl Sci USA 1992;89:5794-8.
12. 1 type. J Biol Chem 1992;267:10935-8.
13. Chomcynski P. A reagent for the single step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. Biotechnics 1993;15:532-5.
14. Högestätt ED, Andersson KE, Edvinsson L. Mechanical properties of rat cerebral arteries as studied by a sensitive device for recording of mechanical activity in isolated small blood vessels. Acta Physiol Scand 1983;117:49-61.
15. Schild HO. pA, a new scale for the measurement of drug antagonism. Br J Pharmacol 1947;2:189-206.
16. Lew MJ, Angus JA. Analysis of competitive agonist-antagonist interactions by nonlinear regression. Trends Pharmacol Sci 1995;16:328-37.
17. Wahlestedt C, Yanaihara N, Håkanson R. Evidence for different pre- and postjunctional receptors for neuropeptide Y and related peptides. Regul Pept 1986;13:307-18.
18. 1 receptor antagonist: BIBP 3226. Eur J Pharmacol 1994;271:11-3.
19. 1 antagonist BIBP 3226. Br J Pharmacol 1995;116:2245-50.
20. 1 receptors mediating vasoconstriction in human cerebral arteries. Neurosci Lett 1996;203:1-4.
21. 1 receptor antagonist. Pharmacol Toxicol 1995;(76 suppl IV):76.
22. 3 receptors. Eur J Pharmacol 1995;278:R3-5.
23. 1 receptor antagonist BIBP3226. J Pharmacol Exp Ther 1995;275:143-9.
24. 1 receptor antagonist BIBP3226. Br J Pharmacol 1995;116:2971-82.