Mechanisms of intrinsic asthma

Current Opinion in Allergy and Clinical Immunology

Volumn 4, Issue 1, 2004, Pages 53-56

  Corrigan, Chris ^a,b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b GUY S HOSPITAL   (United Kingdom)

Author keywords

Immunoglobulin E; Intrinsic asthma; Nonatopic asthma

Indexed keywords

IMMUNOGLOBULIN E ANTIBODY; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR; INTERLEUKIN 5; INTERLEUKIN 5 RECEPTOR; MESSENGER RNA; METALLOPROTEINASE; METALLOPROTEINASE ADAM 33; MONOCYTE CHEMOTACTIC PROTEIN 3; MONOCYTE CHEMOTACTIC PROTEIN 4; RANTES; STAT6 PROTEIN; UNCLASSIFIED DRUG;

ANTIBODY PRODUCTION; ANTIBODY SPECIFICITY; ASTHMA; ATOPY; BRONCHUS MUCOSA; CHRONIC DISEASE; EPIDEMIOLOGICAL DATA; GENETIC PREDISPOSITION; HUMAN; IMMUNE RESPONSE; IMMUNOTHERAPY; PATHOGENESIS; PRICK TEST; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; SKIN TEST; T LYMPHOCYTE ACTIVATION;

ASTHMA; CYTOKINES; HUMANS; HYPERSENSITIVITY, IMMEDIATE; INFLAMMATION MEDIATORS;

EID: 4143067911     PISSN: 15284050     EISSN: None     Source Type: Journal    
DOI: 10.1097/00130832-200402000-00011     Document Type: Review

References (29)

1. Rackeman FM. A working classification of asthma. Am J Med 1947; 33:601-606.
2. Johansson SGO, Hourihane JO'B, Bousquet J, et al. A revised nomenclature for allergy: an EAACI position statement from the EAACI nomenclature task force [position paper]. Allergy 2001; 56:813-824.
3. Mungan D, Bavbek S, Peksari V, et al. Trichophyton sensitivity in allergic and nonallergic asthma. Allergy 2001; 108:21-28.
4. Kauffmann F, Dizier M-H. EGEA (Epidemiological study on the Genetics and Environment of Asthma, Bronchial Hyperresponsiveness and Atopy): design issues. Clin Exp Allergy 1995; 25 Suppl 2:19-22.
5. Romanet-Manent S, Charpin D, Magnan A, et al. Allergic vs nonallergic asthma: what makes the difference? Allergy 2002; 57:607-613. A modern reproduction of Rackeman's original observation (Ref. [1]).
6. Sporik R, Holgate ST, Platts-Mills T, et al. Exposure to house dust mite allergen (Der p1) and the development of asthma in childhood. N Engl J Med 1990; 323:502-507.
7. Peat JK, Salome CM, Woolcock AJ. Longitudinal changes in atopy during a 4-year period: relation to bronchial hyperresponsiveness and respiratory symptoms in a population sample of Australian schoolchildren. J Allergy Clin Immunol 1990; 85:65-74.
8. Gotzsche PC, Johansen HK, Hammarquist C, et al. House dust mite control measures for asthma [Cochrane review]. The Cochrane Library, issue 3. Oxford Update Software; 2001.
9. Barbee RA, Hallon M, Kaltenborn W, et al. A longitudinal study of serum IgE in a community cohort: correlations with age, sex, smoking and atopic status. J Allergy Clin Immunol 1987; 79:919-927.
10. Beeh KM, Ksoll M, Buhl R. Elevation of total serum immunoglobulin E is associated with asthma in nonallergic individuals. Eur Respir J 2000; 16:609-614.
11. Van Eerdewegh P, Little RD, Dupuis J, et al. Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. Nature 2002; 418:426-430. The first demonstration of an asthma susceptibility gene identified by positional cloning, which suggests that susceptibility to asthma may lie in intrinsic abnormalities of the target organ.
12. Novembre E, Cianferoni A, Lombardi E, et al. Natural history of 'intrinsic' atopic dermatitis. Allergy 2001; 56:452-453.
13. Kerschenlohr K, Decard S, Darsow U, et al. Clinical and immunologic reactivity to aeroallergens in 'intrinsic' atopic dermatitis patients. J Allergy Clin Immunol 2003; 111:195-197. A study suggesting that patients with negative skin prick tests may nevertheless show cutaneous reactivity to aeroallergens.
14. Bentley AM, Menz G, Storz C, et al. Identification of T lymphocytes, macrophages, and activated eosinophils in the bronchial mucosa in intrinsic asthma: relationship to symptoms and bronchial responsiveness. Am Rev Respir Dis 1992; 146:500-506.
15. Bentley AM, Durham SR, Kay AB. Comparison of the immunopathology of extrinsic, intrinsic and occupational asthma. J Investig Allergol Clin Immunol 1994; 4:222-232.
16. Humbert M, Durham SR, Ying S, et al. IL-4 and IL-5 mRNA and protein in bronchial biopsies from patients with atopic and nonatopic asthma: evidence against 'intrinsic' asthma being a distinct immunopathologic entity. Am J Respir Crit Care Med 1996; 154:1497-1504.
17. Ying S, Humbert M, Barkans J, et al. Expression of IL-4 and IL-5 mRNA and protein product by CD4+ and CD8+ T cells, eosinophils and mast cells in bronchial biopsies obtained from atopic and non-atopic (intrinsic) asthmatics. J Immunol 1997; 158:3539-3544.
18. Humbert M, Durham SR, Kimmitt P, et al. Elevated expression of messenger ribonucleic acid encoding interleukin-13 in the bronchial mucosa of atopic and non-atopic subjects with asthma. J Allergy Clin Immunol 1997; 99:657-665.
19. Kotsimbos TC, Ghaffar O, Minshall EM, et al. Expression of the IL-4 receptor alpha-subunit is increased in bronchial biopsy specimens from atopic and nonatopic asthma subjects. J Allergy Clin Immunol 1998; 102:859-866.
20. Yasruel Z, Humbert M, Kotsimbos TC, et al. Membrane-bound and soluble alpha IL-5 receptor mRNA in the bronchial mucosa of atopic and nonatopic asthmatics. Am J Respir Crit Care Med 1996; 154:1497-1504.
21. Kotsimbos AT, Humbert M, Minshall E, et al. Upregulation of alpha GM-CSF-receptor in nonatopic asthma but not in atopic asthma. J Allergy Clin Immunol 1997; 99:666-672.
22. Humbert M, Ying S, Corrigan C, et al. Bronchial mucosal expression of the genes encoding chemokines RANTES and MCP-3 in symptomatic atopic and nonatopic asthmatics: relationship to the eosinophil-active cytokines interleukin (IL)-5, granulocyte macrophage-colony-stimulating factor, and IL-3. Am J Respir Cell Mol Biol 1997; 16:1-8.
23. Ying S, Meng Q, Zeibecoglou K, et al. Eosinophil chemotactic chemokines (eotaxin, eotaxin-2, RANTES, monocyte chemoattractant protein-3 (MCP-3) and MCP-4), and C-C chemokine receptor 3 expression in bronchial biopsies from atopic and nonatopic (intrinsic) asthmatics. J Immunol 1999; 163:6321-6329.
24. Zeibecoglou K, Ying S, Meng Q, et al. Expression of eotaxin in induced sputum of atopic and nonatopic asthmatics. Allergy 2000; 55:1042-1048.
25. Folkard SG, Westwick J, Millar AB. Production of interleukin-8, RANTES and MCP-1 in intrinsic and extrinsic asthmatics. Eur Respir J 1997; 10:2097-2104.
26. Christodoulopoulos P, Cameron L, Nakamura Y, et al. TH2 cytokine-associated transcription factors in atopic and nonatopic asthma: evidence for differential signal transducer and activator of transcription 6 expression. J Allergy Clin Immunol 2001; 107:586-591.
27. Humbert M, Grant JA, Taborda-Barata L, et al. High-affinity IgE receptor (FcepsilonRI)-bearing cells in bronchial biopsies from atopic and nonatopic asthma. Am J Respir Crit Care Med 1996; 153:1931-1937.
28. Ying S, Humbert M, Meng Q, et al. Local expression of epsilon germline gene transcripts and RNA for the epsilon heavy chain of IgE in the bronchial mucosa in atopic and nonatopic asthma. J Allergy Clin Immunol 2001; 107:686-692.
29. Berger WE. Monoclonal anti-IgE antibody: a novel therapy for allergic airways disease. Ann Allergy Asthma Immunol 2002; 88:152-160. An up-to-date summary of the therapeutic effects of humanized anti-IgE antibody in atopic asthma; at present, studies on nonatopic patients have not been performed.