Effects of GP2 expression on secretion and endocytosis in pancreatic AR4-2J cells

Biochemical and Biophysical Research Communications

Volumn 322, Issue 1, 2004, Pages 320-325

  Yu, Su ^a   Hao, Ying ^a   Lowe, Anson W ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

Endocytosis; Exocrine; GP2; Membrane protein; Pancreas; Secretion; Secretory granule; Secretory pathway

Indexed keywords

AMYLASE; CHOLECYSTOKININ OCTAPEPTIDE; GP2 PROTEIN; MEMBRANE PROTEIN; UNCLASSIFIED DRUG;

ADENOVIRUS; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENDOCYTOSIS; GENE OVEREXPRESSION; IMMUNOELECTRON MICROSCOPY; NONHUMAN; PANCREAS; PANCREAS CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN SECRETION; RAT; RECYCLING;

AMYLASES; ANIMALS; CARCINOMA, ACINAR CELL; CELL LINE, TUMOR; ENDOCYTOSIS; MEMBRANE GLYCOPROTEINS; PANCREATIC NEOPLASMS; RATS; RECOMBINANT PROTEINS; TRANSPORT VESICLES;

ADENOVIRIDAE;

EID: 4143053547     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.07.120     Document Type: Article

References (29)

1. G.E. Palade Intracellular aspects of the process of protein secretion Science 189 1975 347 358
2. R.J. MacDonald, and R.A. Ronzio Comparative analysis of zymogen granule membrane polypeptides Biochem. Biophys. Res. Commun. 49 1972 377 382
3. R.A. Ronzio, K.E. Kronquist, D.S. Lewis, R.J. MacDonald, S.H. Mohrlok, and J.J. O'Donnell Jr. Glycoprotein synthesis in the adult rat pancreas, I.V. subcellular distribution of membrane glycoproteins Biochim. Biophys. Acta 508 1978 65 84
4. S.-I. Fukuoka, S.D. Freedman, and G.A. Scheele A single gene encodes membrane-bound and free forms of GP-2, the major glycoprotein in pancreatic secretory (zymogen) granule membranes Proc. Natl. Acad. Sci. USA 88 1991 2898 2902
5. B.A. Fritz, and A.W. Lowe Polarized secretion of a GPI-anchored exocrine granule protein by apical membrane-restricted proteolysis Am. J. Physiol. 270 1996 G176 G183
6. T.C. Hoops, and M.J. Rindler Isolation of the cDNA encoding glycoprotein-2 (GP-2), the major zymogen granule membrane protein J. Biol. Chem. 266 1991 4257 4263
7. K. Schmidt, M. Schrader, H.-F. Kern, and R. Kleene Regulated apical secretion of zymogens in rat pancreas: involvement of the GPI-anchored glycoprotein GP-2, the lectin ZG16p and cholesterol-glycosphingolipid enriched microdomains J. Biol. Chem. 276 2001 14315 14323
8. K. Schmidt, H. Dartsch, D. Linder, H.-F. Kern, and R. Kleene A submembranous matrix of proteoglycans on zymogen granule membranes is involved in granule formation in rat pancreatic acinar cells J. Cell Sci. 113 2000 2233 2242
9. I. Kalus, A. Hodel, A. Koch, R. Kleene, J.M. Edwardson, and M. Schrader Interaction of syncollin with GP-2, the major membrane protein of pancreatic zymogen granules, and association with lipid microdomains Biochem. J. 362 2002 433 442
10. V. Colomer, K. Lai, T.C. Hoops, and M.J. Rindler Exocrine granule specific packaging signals are present in the polypeptide moiety of the pancreatic granule membrane protein GP2 and in amylase: implications for protein targeting to secretory granules EMBO J. 13 1994 3711 3719
11. S.-I. Fukuoka, S.D. Freedman, H. Yu, V.P. Sukhatme, and G.A. Scheele GP-2/THP gene family encodes self-binding glycosylphosphatidylinositol-anchored proteins in apical secretory compartments of pancreas and kidney Proc. Natl. Acad. Sci. USA 89 1992 1189 1193
12. M. Jacob, J. Laine, and D. LeBel Specific interactions of pancreatic amylase at acidic pH. Amylase and the major protein of the zymogen granule membrane (GP-2) bind to immobilized or polymerized amylase Biochem. Cell Biol. 70 1992 1105 1114
13. S.D. Freedman, and G.A. Scheele Reversible pH-induced homophilic binding of GP2, a glycosyl-phosphatidylinositol-anchored protein in pancreatic zymogen granule membranes Eur. J. Cell Biol. 61 1993 229 238
14. F.A. Leblond, G. Viau, J. Laine, and D. LeBel Reconstitution in vitro of the pH-dependent aggregation of pancreatic zymogens en route to the secretory granule: implication of GP-2 Biochem. J. 291 1993 289 296
15. D.S. Longnecker, H.S. Lilja, J. French, E. Kuhlmann, and W. Noll Transplantation of azaserine-induced carcinomas of pancreas in rats Cancer Lett. 7 1979 197 202
16. C.D. Logsdon, K.J. Perot, and A.R. McDonald Mechanism of glucocorticoid-induced increase in pancreatic amylase gene transcription J. Biol. Chem. 262 1987 15765 15769
17. P. Arvan, and J.D. Castle Phasic release of newly synthesized secretory proteins in the unstimulated rat exocrine pancreas J. Cell Biol. 104 1987 243 252
18. A. Dittie, and H.-F. Kern The major zymogen granule membrane protein GP-2 in the rat pancreas is not involved in granule formation Eur. J. Cell Biol. 58 1992 243 258
19. S.D. Freedman, H.-F. Kern, and G.A. Scheele Cleavage of GPI-anchored proteins from the plasma membrane activates apical endocytosis in pancreatic acinar cells Eur. J. Cell Biol. 75 1998 163 173
20. S.D. Freedman, P. Blanco, J.C. Shea, and J.G. Alvarez Mechanisms to explain pancreatic dysfunction in cystic fibrosis Med. Clin. North Am. 84 2000 657 664
21. S.D. Freedman, H.-F. Kern, and G.A. Scheele Acinar lumen pH regulates endocytosis, but not exocytosis, at the apical plasma membrane of pancreatic acinar cells Eur. J. Cell Biol. 75 1998 153 162
22. S.D. Freedman, H.F. Kern, and G.A. Scheele Pancreatic acinar cell dysfunction in CFTR(-/-) mice is associated with impairments in luminal pH and endocytosis Gastroenterology 121 2001 950 957
23. H. Mizuguchi, and M.A. Kay A simple method for constructing E1- and E1/E4-deleted recombinant adenoviral vectors Hum. Gene Ther. 10 1999 2013 2017
24. C.D. Logsdon, J. Mossner, J.A. Williams, and I.D. Goldfine Glucocorticoids increase amylase mRNA levels, secretory organelles, and secretion in pancreatic acinar AR42J cells J. Cell Biol. 100 1985 1200 1208
25. B.A. Fritz, C.S. Poppel, M.W. Fei, and A.W. Lowe Processing of the major pancreatic zymogen granule membrane protein, GP2 Pancreas 24 2002 336 343
26. D.M. Toivola, N.-O. Ku, N. Ghori, A.W. Lowe, S.A. Michie, and M.B. Omary Effects of keratin filament disruption on exocrine pancreas-stimulated secretion and susceptibility to injury Exp. Cell Res. 255 2000 156 170
27. M. Husain, and B. Moss Intracellular trafficking of a palmitoylated membrane-associated protein component of enveloped vaccinia virus J. Virol. 77 2003 9008 9019
28. S.D. Freedman New concepts in understanding the pathophysiology of chronic pancreatitis Int. J. Pancreatol. 24 1998 1 8
29. S.D. Freedman, H.-F. Kern, and G.A. Scheele Apical membrane trafficking during regulated pancreatic exocrine secretion - role of alkaline pH in the acinar lumen and enzymatic cleavage of GP2, a GPI-linked protein Eur. J. Cell Biol. 65 1994 354 365