Decreased urinary concentration of Tamm-Horsfall protein is associated with development of renal failure and cardiovascular death within 20 years in type 1 but not in type 2 diabetic patients

Scandinavian Journal of Urology and Nephrology

Volumn 42, Issue 2, 2008, Pages 168-174

  Sejdiu, Ilir ^a   Torffvit, Ole ^a,b  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b Primary Care Unit   (Sweden)

Author keywords

Albuminuria; Cardiovascular death; Death; Diabetic nephropathy; Tamm Horsfall protein; Tubular dysfunction; Uraemia

Indexed keywords

ALBUMIN; CREATININE; GLYCOSYLATED HEMOGLOBIN; TAMM HORSFALL GLYCOPROTEIN;

ADOLESCENT; ADULT; ALBUMINURIA; ARTICLE; BLOOD PRESSURE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CHILD; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIABETIC PATIENT; DISEASE COURSE; FEMALE; FOLLOW UP; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; KIDNEY FAILURE; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROTEIN URINE LEVEL; UREMIA; URINALYSIS;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; CARDIOVASCULAR DISEASES; CAUSE OF DEATH; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; DISEASE PROGRESSION; FEMALE; HUMANS; KIDNEY FAILURE; MALE; MIDDLE AGED; MUCOPROTEINS; PROGNOSIS; RISK FACTORS; ROC CURVE; SURVIVAL RATE; SWEDEN;

EID: 41349120274     PISSN: 00365599     EISSN: 16512065     Source Type: Journal    
DOI: 10.1080/00365590701644691     Document Type: Article

References (35)

1. Rasch R, Torffvit O, Bachman S, Jensen PK, Jacobsen NO. Tamm-Horsfall glycoprotein in streptozotocin diabetic rats: a study of kidney in situ hybridization, immunohistochemistry and urinary excretion. Diabetologia 1995;38:525-35.
2. Ginevri F, Piccotti E, Alinovi R, DeToni T, Biagini C, Chiggeri GM, et al. Reversible tubular proteinuria precedes microalbuminuria and correlates with the metabolic status in diabetic children. Pediatr Nephrol 1993;7:23-6.
3. Pfleiderer S, Zimmerhackl L, Kinne R, Manz F, Schuler G, Brandis M. Renal proximal and distal tubular function is attenuated in diabetes mellitus type 1 as determined by the renal excretion of a1-microglobulin and Tamm-Horsfall protein. Clin Invest 1993;71:972-7.
4. Schultz C, Dalton R, Neil H, Konopelska-Bahu T, Dunger D, on behalf of the Oxford Regional Prospective Study Group. Markers of renal tubular dysfunction measured annually do not predict risk of microalbuminuria in the first few years after diagnosis of Type 1 diabetes. Diabetologia 2001;44:224-9.
5. Torffvit O, Jørgensen PE, Kamper A-L, Holstein-Rathlou NH, Leyssac PP, Poulsen SS, et al. Urinary excretion of Tamm-Horsfall protein and epidermal growth factor in chronic nephropathy. Nephron 1998;79:167-72.
6. Torffvit O, Agardh C-D. Urinary excretion rate of NC1 and Tamm-Horsfall protein in the microalbuminuric type I diabetic patient. J Diabetes Complications 1994;8:77-83.
7. Torffvit O, Melander O, Hultén UL. Urinary excretion rate of Tamm-Horsfall protein is related to salt intake in humans. Nephron Physiol 2004;97:31-6.
8. Thorup C, Ollerstam A, Persson AEG, Torffvit O. Increased tubuloglomerular feedback activity is associated with increased NO production in the streptozotocin-diabetic rat. J Diabetes Complications 2000;14:46-52.
9. Mo L, Zhu X-H, Huang H-Y, Shapiro E, Hasty D, Wu X-R. Ablation of the Tamm-Horsfall protein gene increases susceptibility of mice to bladder colonization by type 1-fimbriated Escherichia coli. Am J Physiol Renal Physiol 2004;286:F795-802.
10. Ronald A, Ludwig E. Urinary tract infections in adults with diabetes. Int J Antimicrobial Agents 2001;17:287-92.
11. Kokot F, Dulawa J. Tamm-Horsfall protein updated. Nephron 2000;85:97-102.
12. Holmquist P, Torffvit O, Jorgensen P, Torring N, Nexo E, Sjöblad S. Early urinary changes in Tamm-Horsfall protein and epidermal growth factor in diabetic children. Pediatr Nephrol 2001;16:488-92.
13. Osterby R, Tapia J, Nyberg G, Tencer J, Willner J, Rippe B, et al. Renal structures in type 2 diabetic patients with elevated albumin excretion rate. APMIS 2001;109:751-61.
14. Bakoush O, Tencer J, Tapia J, Rippe B, Torffvit O. Higher urinary IgM excretion in type 2 diabetic nephropathy compared to type 1 diabetic nephropathy. Kidney Int 2002;61:203-8.
15. Torffvit O, Wieslander J. A simplified enzyme-linked immunosorbent assay for urinary albumin. Scand J Clin Lab Invest 1986;46:545-8.
16. Torffvit O, Agardh C-D, Kjellsson B, Wieslander J. Tubular secretion of Tamm-Horsfall protein in type 1 (insulin-dependent) diabetes mellitus using a simplified enzyme linked immunoassay. Clin Chim Acta 1992;205:31-41.
17. Krutzén E, Bäck S, Nilsson-Ehle I, Nilsson-Ehle P. Plasma clearance of a new contrast agent, iohexol: a method for the determination of glomerular filtration rate. J Lab Clin Med 1984;104:955-61.
18. Levey A, Greene T, Kusek J, Beck G. A simplified equation to predict glomerular filtration rate from serum creatinine. J Am Soc Nephrol 2000;11:155:A0828.
19. Below A, Chakraborty J, Khuder S, Haselhuhn GD. Evaluation of urinary Tamm-Horsfall protein in post-menopausal diabetic women. J Diabetes Complications 1999;13:204-10.
20. Torffvit O, Agardh C-D. The impact of metabolic and blood pressure control on incidence and progression of nephropathy. A 10-year study of 385 type 2 diabetic patients. J Diabetes Complications 2001;15:307-13.
21. Torffvit O, Tapia J, Rippe B, Alm P, Willner J, Tencer J. Ambulatory blood pressure in type 2 diabetic patients with albuminuria. Relation to the renal function and structural lesions. J Diabetes Complications 2004;18:328-35.
22. Torffvit O, Agardh C-D. The prognosis for type 2 diabetic patients with heart disease. A 10-year observation study of 385 patients. J Diabetes Complications 2000;14:301-6.
23. Torffvit O, Rippe B. Size and charge selectivity of the glomerular filter in patients with insulin-dependent diabetes mellitus: urinary immunoglobulins and glycosaminoglycans. Nephron 1999;83:301-7.
24. Gall M-A, Rossing P, Kofoed-Enevoldsen A, Nielsen F, Parving H-H. Glomerular size- and charge selectivity in type 2 (non-insulin-dependent) diabetic patients with diabetic nephropathy. Diabetologia 1994;37:195-201.
25. Taft J, Nolan C, Yeung S, Hewitson T, Martin IR. Clinical and histological correlations of decline in renal function in diabetic patients with proteinuria. Diabetes 1994;43:1046-51.
26. Brocco E, Fioretto P, Mauer M, Saller A, Carraro A, Frigato F, et al. Renal structure and function in non-insulin dependent diabetic patients with microalbuminuria. Kidney Int Suppl 1997;63:S40-4.
27. Agardh C-D, Tallroth G, Hultberg B. Urinary N-acetyl-β-D- glucosaminidase activity does not predict development of diabetic nephropathy. Diabetes Care 1987;10:604-6.
28. Bangstad H-J, Kofoed-Enevoldsen A, Dahl-Jørgensen K, Hanssen KF. Glomerular charge selectivity and the influence of improved blood glucose control in Type 1 (insulin-dependent) diabetic patients with microalbuminuria. Diabetologia 1992;35:1165-9.
29. Thulesen J, Jørgensen P, Torffvit O, Nexø E, Poulsen SS. Urinary excretion of epidermal growth factor and Tamm-Horsfall protein in three rat models with increased renal excretion of urine. Regul Pept 1997;72:179-86.
30. Holdaas H, Hartmann A, Lien M, Nilsen L, Jervell J, Fauchald P, et al. Contrasting effects of lisinopril and nifedipine on albuminuria and tubular transport functions in insulin dependent diabetics with nephropathy. J Intern Med 1991;229:163-70.
31. Gatling W, Knight C, Hill RD. Screening for early diabetic nephropathy: which sample to detect microalbuminuria? Diabet Med 1985;2:451-5.
32. Torffvit O, Lövestam-Adrian M, Agardh E, Agardh C-D. Nephropathy, but not retinopathy, is associated with the development of heart disease in type 1 diabetes: a 12 year observation study of 462 patients. Diabet Med 2005;22:723-9.
33. Nordwall M, Bojestig M, Arnqvist H, Ludvigsson J. Declining incidence of severe retinopathy and persisting decrease of nephropathy in an unselected population of type 1 diabetes - the Linköping Diabetes Complications Study. Diabetologia 2004;47:1266-72.
34. Bachmann S, Mutig K, Bates J, Welker P, Geist B, Gross V, et al. Renal effects of Tamm-Horsfall protein (uromodulin) deficiency in mice. Am J Physiol Renal Physiol 2005;288:F559-67.
35. Tuomilehto J, Jousilahti P, Rastenyte D, Moltchanov V, Tanskanen A, Pietinen P. Urinary sodium excretion and cardiovascular mortality in Finland: a prospective study. Lancet 2001;357:848-51.