Markers of renal tubular dysfunction measured annually do not predict risk of microalbuminuria in the first few years after diagnosis of Type I diabetes

Diabetologia

Volumn 44, Issue 2, 2001, Pages 224-229

  Schultz, C J ^a   Dalton, R N ^b   Neil, H A W ^a   Konopelska Bahu, T ^c   Dunger, D B ^c  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b GUY S HOSPITAL   (United Kingdom)

^c ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

Glycated haemoglobin; Microangiopathy; Nephropathy; Proximal renal tubular dysfunction

Indexed keywords

ACETYLGLUCOSAMINIDASE; ALBUMIN; CREATININE; HEMOGLOBIN A1C; RETINOL BINDING PROTEIN;

ADOLESCENT; ARTICLE; CHILD; DISEASE COURSE; EARLY DIAGNOSIS; FEMALE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; KIDNEY TUBULE DISORDER; MAJOR CLINICAL STUDY; MALE; MICROALBUMINURIA; MICROANGIOPATHY; PRIORITY JOURNAL; PROTEINURIA; RISK FACTOR; URINALYSIS;

ACETYLGLUCOSAMINIDASE; ADOLESCENT; ALBUMINURIA; BIOLOGICAL MARKERS; CHILD; CHILD, PRESCHOOL; DIABETES MELLITUS, TYPE 1; FEMALE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; INFANT; KIDNEY TUBULES; MALE; PUBERTY; RETINOL-BINDING PROTEINS; TIME FACTORS;

EID: 0035131034     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250051603     Document Type: Article

References (28)

1. Microalbuminuria, blood pressure and diabetic renal disease: Origin and development of ideas
2. Microalbuminuria as a predictor of clinical nephropathy in insulin-dependent diabetes mellitus
3. Improvement of blood glucose control in IDDM patients retards the progression of morphological changes in early diabetic nephropathy
4. Ambulatory blood pressure in the transition from normo- to microalbuminuria. A longitudinal study in IDDM patients
5. Diabetic proteinuria. Glomerular or tubular in origin?
6. The retinol-binding protein
7. Renal tubular proteinuria and microalbuminuria in diabetic patients
8. Quantitative distribution of lysosomal hydrolases in the rat nephron
9. Enzymuria as a marker of renal injury and disease: Studies of N-acetyl beta-glucosaminidase in the general population and in patients with renal disease
10. Predictive value of tubular markers for the development of microalbuminuria in adolescents with diabetes
11. Urinary Nacetyl-beta-D-glucosaminidase activity does not predict development of diabetic nephropathy
12. Comparison of urinary albumin, retinol-binding protein and N-acetyl beta-glucosaminidase as predictors of progression of low level albuminuria in diabetes
13. Microalbuminuria prevalence varies with age, sex and puberty in children with insulin dependent diabetes followed in a longitudinal Study from diagnosis
14. Rising incidence of insulin dependent diabetes in children aged under 5 years in the Oxford region: Time trend analysis
15. Freezing method affects the concentration and variability of urine proteins and the interpretation of data on microalbuminuria
16. Measurement of beta 2-microglobulin, retinol-binding protein, alpha 1-microglobulin and urine protein 1 in healthy children using enzyme-linked immunosorbent assay
17. Rapid colorimetric assay of beta-galactosidase and N-acetyl-beta- glucosaminidase in human urine
18. Prior heat stress inhibits apoptosis in adenosine triphosphate-depleted renal tubular cells
19. Differential responsiveness of proximal tubule segments to metabolic inhibitors in the isolated perfused rat kidney
20. The use of urinary Nacetyl-beta-glucosaminidase in human renal toxicology. 1. Partial biochemical characterization and excretion in humans and release from the isolated perfused rat kidney
21. Degradation of polysaccharides, mucopolysaccharides, and glycoproteins by lysosomal glycosidases
22. Urine Nacetyl-beta-D-glucosaminidase - A marker of tubular damage?
23. Reversible tubular proteinuria precedes microalbuminuria and correlates with the metabolic status in diabetic children
24. Retinol-binding protein mRNA is induced by estrogen in the kidney but not in the liver
25. Evidence of facilitory effect of growth hormone on tissue vitamin A uptake in rats
26. Renal involvement in mitochondrial cytopathies
27. Deletions in the mitochondrial DNA and decrease in the oxidative phosphorylation activity of children with Fanconi syndrome secondary to antiblastic therapy
28. Increased transcapillary escape rate of albumin in Type I (insulin-dependent) diabetic patients with microalbuminuria