Structural Insight into the Mechanism of Substrate Specificity and Catalytic Activity of an HD-Domain Phosphohydrolase: The 5′-Deoxyribonucleotidase YfbR from Escherichia coli

Journal of Molecular Biology

Volumn 378, Issue 1, 2008, Pages 215-226

  Zimmerman, Matthew D ^a,b   Proudfoot, Michael ^c,d   Yakunin, Alexander ^c,d   Minor, Wladek ^a,b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b Midwest Center for Structural Genomics

^c UNIVERSITY OF TORONTO   (Canada)

^d PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

5 nucleotidase; alanine scanning mutagenesis; enzyme mechanism; HD domain phosphohydrolase; macromolecular crystallography

Indexed keywords

2' DEOXYRIBOADENOSINE; 5' DEOXYRIBONUCLEOTIDASE; 5' MONOPHOSPHATE; 5' NUCLEOTIDASE; ALANINE; DEOXYRIBOSE; INDOLE; PHOSPHATASE; PHOSPHATE; RIBOSE; THYMIDINE PHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; COMPARATIVE STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME SPECIFICITY; ENZYME STABILITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; ESCHERICHIA COLI; HYDROGEN BOND; MOLECULAR BIOLOGY; MUTAGENESIS; MUTANT; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

ESCHERICHIA COLI;

EID: 41249100715     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2008.02.036     Document Type: Article

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