Metabolomic analysis of Strychnos nux-vomica, Strychnos icaja and Strychnos ignatii extracts by 1H nuclear magnetic resonance spectrometry and multivariate analysis techniques

Phytochemistry

Volumn 65, Issue 13, 2004, Pages 1993-2001

  Frédérich, Michel ^a,b   Choi, Young Hae ^a   Angenot, Luc ^b   Harnischfeger, Goetz ^c   Lefeber, Alfons W M ^d   Verpoorte, Robert ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b UNIVERSITY OF LIÈGE   (Belgium)

^c Schaper & Brummer GmbH & Co KG   (Germany)

^d LEIDEN UNIVERSITY   (Netherlands)

Author keywords

1H NMR; Alkaloid; Brucine; Loganiaceae; Metabolic profiling; Multivariate analysis; PCA; Strychnine; Strychnos icaja; Strychnos ignatii; Strychnos nux vomica

Indexed keywords

ALKALOID DERIVATIVE; ALPHA COLUBRINE; BETA COLUBRINE; BRUCINE; EPOXYNOVACINE; FATTY ACID; ICAJINE; ISOSUNGUCINE; LOGANIN; NOVACINE; PLANT EXTRACT; STRYCHNINE; STRYCHNOS ICAJA EXTRACT; STRYCHNOS IGNATII EXTRACT; STRYCHNOS NUX VOMICA EXTRACT; SUCROSE; SUNGUCINE; UNCLASSIFIED DRUG; VOMICINE;

ARTICLE; BARK; MEDICINAL PLANT; MULTIVARIATE ANALYSIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PLANT LEAF; PLANT SEED; PLANT STEM; PRINCIPAL COMPONENT ANALYSIS; STATISTICAL ANALYSIS; STRYCHNOS; STRYCHNOS ICAJA; STRYCHNOS IGNATII; STRYCHNOS NUX VOMICA;

MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; MULTIVARIATE ANALYSIS; PLANT EXTRACTS; STRYCHNOS;

LOGANIACEAE; STRYCHNOS; STRYCHNOS ICAJA; STRYCHNOS NUX-VOMICA; STRYCHNOS TOXIFERA;

EID: 3242815255     PISSN: 00319422     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phytochem.2004.06.015     Document Type: Article

References (33)

1. Ambasta, S.S.P., 1986. The Useful Plants of India. Publications and Information Directorate, New Delhi, pp. 604-606
2. 1H NMR spectroscopy and chemometrics. Planta Medica. 68:2002;734-738
3. Baser K.H.C., Bisset N.G. Alkaloids of Sri Lankan Strychnos nux-vomica. Phytochemistry. 21:1982;1423-1429
4. Bisset N.G. The Asian species of Strychnos. Part III. The ethnobotany. Lloydia. 37:1974;62-107
5. Bisset N.G. The Asian species of Strychnos. Part IV. The alkaloids. Lloydia. 39:1976;263-315
6. Bisset N.G., Choudhury A.K. Alkaloids from the leaves of Strychnos wallichiana. Phytochemistry. 13:1974;259-263
7. Bisset N.G., Walker M.D. Alkaloids from the stem bark of Strychnos ignatii. Phytochemistry. 13:1974;525-526
8. Bratati D., Bisset N.G. Alkaloids of Strychnos ignatii. Planta Medica. 56:1990;133
9. Bundy J.G., Spurgeon D.J., Svendsen C., Hankard P.K., Osborn D., Lindon J.C., Nicholson J.K. Earthworm species of the genus Eisenia can be phenotypically differentiated by metabolic profiling. FEBS Letters. 521:2002;115-120
10. Denoel A. Le Strychnos icaja Baillon du Congo Belge. Journal de Pharmacie de Belgique. 5:1950;59-77
11. Dymock, W., Warden, C.J.H., Hooper, D., 1891. Pharmacographia Indica. A History of the Principal Drugs of Vegetable Origin. Trench, Trübner & Co, London, pp. 458-505
12. Eriksson L., Johansson E., Kettaneh-Wold N., Wold S. Multi- and Megavariate Data Analysis. 2001;Umetrics Academy, Umeå, Sweden
13. Felter H.W., Lloyd J.U. King's American Dispensatory. 1898;Ohio Valley Co., Cincinnati
14. Flückiger F.A., Hanbury D. Histoire des Drogues d'Origine Végétale. 1878;Octave Doin, Paris
15. Frédérich M., De Pauw M., Prosperi C., Tits M., Brandt V., Penelle J., Hayette M., DeMol P., Angenot L. Strychnogucines A and B, two new antiplasmodial bisindole alkaloids from Strychnos icaja. Journal of Natural Products. 64:2001;12-16
16. Frédérich M., Depauw-Gillet M.C., Llabres G., Tits M., Hayette M.P., Brandt V., Penelle J., De Mol P., Angenot L. New anti-malarial and cytotoxic sungucine derivatives from Strychnos icaja roots. Planta Medica. 66:2000;262-269
17. Gadi-Biala R., Tits M., Wauters J.N., Angenot L. A new HPLC method for the assay of alkaloids in Strychnos nux-vomica and Strychnos ignatii. Fitoterapia. 67:1996;163-165
18. Gathercoal E.N., Wirth E.H. Pharmacognosy. 1947;Lea and Fegiger, Philadelphia
19. Grieve, M., 1971. A Modern Herbal, vol. 1, Dover Publications, New York, pp. 51-53
20. Iwu, M., 1993. Handbook of African Medicinal Plants. CRC Press, Boca Raton, pp. 244-245
21. Jacquemond-Collet I., Hannedouche S., Fabre N., Fouraste I., Moulis C. Two tetrahydroquinoline alkaloids from Galipea officinalis. Phytochemistry. 51:1999;1167-1169
22. Kambu K., Coune C., Angenot L. Nouveaux alcaloïdes des racines du Strychnos icaja. Planta Medica. 37:1980;161-164
23. Krukoff B.A., Marini-Bettolo G.B., Bisset N.G. American species of Strychnos. Lloydia. 35:1972;193-271
24. Marini-Bettolo G.B., Ciasca M.A., Galeffi C., Bisset N.G., Krukoff B.A. The occurrence of strychnine and brucine in an American species of Strychnos. Phytochemistry. 11:1972;381-384
25. Neuwinger H.D. African Ethnobotany: Poisons and Drugs, Chemistry, Pharmacology, Toxicology. 1996;Chapman & Hall, London
26. Perrot E. Matières Premières Usuelles du Règne Végétal. 1943;Masson, Paris
27. Philippe G., De Mol P., Zeches-Hanrot M., Nuzillard J.M., Tits M.H., Angenot L., Frederich M. Indolomonoterpenic alkaloids from Strychnos icaja roots. Phytochemistry. 62:2003;623-629
28. Schaneberg B.T., Crockett S., Bedir E., Khan I.A. The role of chemical fingerprinting: application to Ephedra. Phytochemistry. 62:2003;911-918
29. Sefcovic P., Dubravkova L., Torto F.G. Die Alkaloide der Blätter von Strychnos nux-vomica L. Planta Medica. 16:1968;143-146
30. Shaw F.H., de la Lande J.S. The alkaloids of Strychnos lucida. Australian Journal of Experimental Biological and Medicinal Sciences. 26:1948;199-203
31. Sumner L.W., Mendes P., Dixon R.A. Plant metabolomics: large-scale phytochemistry in the functional genomics era. Phytochemistry. 62:2003;817-836
32. Tschirch A. Handbuch der Pharmakognosie. 1923;Verlag von Chr. Herm. Tauchnitz, Leipzig
33. 1H NMR spectroscopy and multivariate analysis as a technique for metabolite fingerprinting of Arabidopsis thaliana. Phytochemistry. 62:2003;949-957