Aconitine induces prolonged seizure-like events in rat neocortical brain slices

European Journal of Pharmacology

Volumn 584, Issue 2-3, 2008, Pages 291-296

  Voss, Logan J ^a   Voss, Janet M ^a   McLeay, Lance ^b   Sleigh, James W ^a  

^a WAIKATO HOSPITAL   (New Zealand)

^b UNIVERSITY OF WAIKATO   (New Zealand)

Author keywords

(Rat); Aconitine; Cerebral cortex; Cortical slice; Seizure

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; ACONITINE; N METHYL DEXTRO ASPARTIC ACID; PHENYTOIN; SODIUM CHANNEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CEREBROSPINAL FLUID; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; ELECTRIC POTENTIAL; ELECTROENCEPHALOGRAM; FEMALE; HIPPOCAMPUS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SEIZURE;

2-AMINO-5-PHOSPHONOVALERATE; ACONITINE; ACTION POTENTIALS; ANIMALS; CALCIUM; CENTRAL NERVOUS SYSTEM AGENTS; CEREBROSPINAL FLUID; EXCITATORY AMINO ACID ANTAGONISTS; FEMALE; MALE; NEOCORTEX; PHENYTOIN; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; SEIZURES; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; SOMATOSENSORY CORTEX; TIME FACTORS;

EID: 41249091412     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.02.024     Document Type: Article

References (20)

1. Ameri A. Age-dependent differences in sensitivity to aconitine of rat hippocampal slices. Neurosci. Lett. 216 (1996) 13-16
2. Ameri A. The effects of aconitum alkaloids on the central nervous system. Prog. Neurobiol. 56 (1998) 211-235
3. Ameri A., and Peters T. Calcium-dependent, sustained enhancement of excitability during washout of aconitine in rat hippocampal slices. Exp. Brain Res. 114 (1997) 518-524
4. Ameri A., Shi Q., Aschoff J., and Peters T. Electrophysiological effects of aconitine in rat hippocampal slices. Neuropharmacology 35 (1996) 13-22
5. Brysch W., Creutzfeldt O.D., Luno K., Schlingensiepen R., and Schlingensiepen K.H. Regional and temporal expression of sodium channel messenger RNAs in the rat brain during development. Exp. Brain Res. 86 (1991) 562-567
6. Buhl E.H., Tamas G., and Fisahn A. Cholinergic activation and tonic excitation induce persistent gamma oscillations in mouse somatosensory cortex in vitro. J. Physiol. (Lond). 513 (1998) 117-126
7. Catterall W.A. Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes. Annu. Rev. Pharmacol. Toxicol. 20 (1980) 15-43
8. Catterall W.A. Common modes of drug action on Na channels: local anesthetics, antiarrhythmics and anticonvulsants. Trends Pharmacol. Sci. 8 (1987) 57-65
9. Jones G.L., Wimbish G.H., and McIntosh W.E. Phenytoin: basic and clinical pharmacology. Med. Res. Rev. 3 (1983) 383-434
10. Lampl I., Schwindt P., and Crill W. Reduction of cortical pyramidal neuron excitability by the action of phenytoin on persistent Na current. J. Pharmacol. Exp. Ther. 284 (1998) 228-237
11. Mao B.-Q., Hamzei-Sichani F., Aronov D., Froemke R.C., and Yuste R. Dynamics of spontaneous activity in neocortical slices. Neuron 32 (2001) 883-898
12. McLean M.J., and MacDonald R.L. Multiple actions of phenytoin on mouse spinal cord neurons in cell culture. J. Pharmacol. Exp. Ther. 227 (1983) 779-789
13. Nowak L.G., and Bullier J. Spread of stimulating current in the cortical grey matter of rat visual cortex studied on a new in vitro slice preparation. J. Neurosci. Methods 67 (1996) 237-248
14. Popoli M., Brunello N., Perez J., and Racagni G. Second messenger-regulated protein kinases in the brain: their functional role and the action of antidepressant drugs. J. Neurochem. 74 (2000) 21-33
15. Sanchez-Vives M.V., and McCormick D.A. Cellular and network mechanisms of rhythmic recurrent activity in neocortex. Nat. Neurosci. 3 (2000) 1027-1034
16. Schmidt H., and Schmidt O. Effect of aconitine on the sodium permeability of the node of ranvier. Pflugers Arch. 349 (1974) 133-148
17. Schumacher T.B., Beck H., Steinhauser C., Schramm J., and Elger C.E. Effects of phenytoin, carbamazepine and gabapentin on calcium channels in hippocampal granule cells from patients with temporal lobe epilepsy. Epilepsia 39 (1998) 355-363
18. Todorovic S.M., and Lingle C.J. Pharmacological properties of T-type calcium current in adult rat sensory neurons: effects of anticonvulsant and anesthetic agents. J. Neurophysiol. 79 (1998) 240-252
19. Ulbricht W. Sodium channel inactivation: molecular determinants and modulation. Physiol. Rev. 85 (2005) 1271-1301
20. Worley P.F., and Baraban J.M. Site of anticonvulsant action on sodium channels: autoradiographic and electrophysiological studies in rat brain. Proc. Natl. Acad. Sci. U. S. A. 84 (1987) 3051-3055