Electrophysiological effects of aconitine in rat hippocampal slices

Neuropharmacology

Volumn 35, Issue 1, 1996, Pages 13-22

  Ameri, A ^a   Shi, Q ^a   Aschoff, J ^a   Peters, T ^a  

^a UNIVERSITY OF ULM   (Germany)

Author keywords

aconitine; hippocampus; sodium channel; veratridine

Indexed keywords

ACONITINE; SODIUM CHANNEL; VERATRIDINE;

ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; EXCITATORY POSTSYNAPTIC POTENTIAL; HIPPOCAMPUS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0030063290     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/0028-3908(95)00153-0     Document Type: Article

References (21)

1. Andersen P., Silvenius H., Sundberg S. H., Sveen O. and Wigstrom H. (1978) Functional characteristic of myelinated fibers in the hippocampal cortex. Brain Res. 144: 11-18.
2. Ashton D., Willems R., Marrannes R. and Janssen P. A. J. (1990) Extracellular ions during veratridine-induced neurotoxicity in hippocampal slices: neuroprotective effects of flunarizine and tetrodotoxin. Brain Res. 528: 212-222.
3. Carmeliet E. (1991) Ion channels agonists: expectations for therapy. Eur. Heart J. 12: 30-37.
4. Catterall W. A. (1980) Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes. A. Rev. Pharm. Toxic. 20: 15-43.
5. Catterall W. A. (1992) Cellular and molecular biology of voltage-gated sodium channels. Physiol. Rev. 72: 15-48.
6. Dunwiddie T. V. (1986) The use of in vitro brain slices in neuropharmacology. In: Electrophysiological Techniques in Pharmacology. Alan R. Liss, New York.
7. Garaschuk O., Kovalschuk Y. and Krishtal O. (1992) Adenosine-dependent enhancement by methylxanthines of excitatory synaptic transmission in hippocampus of rats. Neurosci. Lett. 135: 10-12.
8. Hansen A. J. and Lauritzen M. (1984) The role of spreading depression in acute brain disorders. Ann. Acad. Bras. Cien. 54: 457-479.
9. Hille B. (1992) Ionic channels of excitable membranes. Sinauer Associates, Sunderland.
10. Honerjager P. and Meissner A. (1983) The positive inotropic effect of aconitine. Naunyn-Schmiedeberg's Archs. Pharmac. 322: 49-58.
11. +-channel blockers in isolated purkinje neurons of rat cerebellum. Neuroscience 54: 575-585.
12. Mozhayeva G. N., Naumov A. P., Negulayev Y. A. and Nosyreva E. D. (1977) The permeability of aconitine-modified sodium channels to univalent cations in myelinated nerve. Biochim. Biophys. Acta 466: 461-473.
13. + channels involved in neuronal cell death: protection by flunarizine. Life Sci. 48: 1881-1893.
14. Prenen G. H. M., Go K. G., Postema F., Zuiderveen F. and Korf J. (1988) Cerebral shifts in hypoxic-ischemic brain damage are prevented by the sodium channel blocker tetrodotoxin. Expl. Neur. 99: 118-132.
15. Schmidt H. and Schmitt O. (1974) Effect of aconitine on the sodium permeability of the node of Ranvier. Plugers Arch. 349: 133-148.
16. Suzuki Y., Oyama T., Ishige A., Isono T., Asami A., Ikeda Y., Noguchi M. and Omiya Y. (1994) Antinociceptive mechanism of the aconitine alkaloids mesaconitine and benzoylmesaconine. Planta Med. 60: 391-394.
17. Tegtmeier F., Xie Y., Scheller D., Gleitz J., Osikowska-Evers B. and Peters T. (1992) The role of sodium channels in cerebral ischemia. Wiss Zeitschrift der Humboldt-Universitat zu Berlin, R. Medizin 41: 45-53.
18. Ulrbricht W. and Flacke W. (1965) The effect of veratridine on excitable membrane of nerve and muscle. Ergeb. Physiol. 61: 18-71.
19. Warashina A. (1985) Frequency-dependent effects of aconitine and veratridine on membrane currents in the crayfish giant axon. Japan J. Physiol. 35: 463-482.
20. Westenbroek R. E., Merrick D. K. and Catterall W. A. (1989) Differential subcellular localization of RI and RII Na+ channel subtypes in central neurons. Neuron 3: 695-704.
21. Worley P. F. and Baraban J. M. (1987) Site of anticonvulsant action on sodium channels: autoradiographic and electro-physiological studies in rat brain. Proc. Natn. Acad. Sci. U.S.A. 84: 3051-3055.