Synthesis and in vivo anti-mutagenic activity of novel melatonin derivatives

European Journal of Medicinal Chemistry

Volumn 43, Issue 4, 2008, Pages 763-770

  Elmegeed, Gamal A ^a   Khalil, Wagdy K B ^a   Raouf, Amira Abdel ^a   Abdelhalim, Mervat M ^a  

^a NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

Cyclophosphamide; Genotoxicity; Melatonin; Pyridazine; Thiadiazole; Thiophene

Indexed keywords

CHOLINESTERASE; CLASTOGEN; CYCLOPHOSPHAMIDE; INDOLE DERIVATIVE; MELATONIN; MELATONIN DERIVATIVE; N [2 [2 (2,5 DIPHENYL 3 IMINOPYRIDAZIN 4 YL) 6 METHOXY 1,3,4 THIADIAZOLO[3,2 A]INDOL 4 YL]ETHYL]ACETAMIDE; N [2 [2 (3 CYANO 2,4 DIAMINOTHIOPHEN 5 YL) 6 METHOXY 1,3,4 THIADIAZOLO[3,2 A]INDOL 4 YL]ETHYL]ACETAMIDE; PEROXIDASE; SCAVENGER; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BONE MARROW CELL; CONTROLLED STUDY; DNA DETERMINATION; ENZYME ACTIVITY; ERYTHROCYTE; FEMALE; GENOTOXICITY; HORMONE SYNTHESIS; IN VIVO STUDY; MICRONUCLEUS; MOUSE; NERVE DEGENERATION; NONHUMAN; RNA ANALYSIS;

ANIMALS; ANTIMUTAGENIC AGENTS; ANTINEOPLASTIC AGENTS, ALKYLATING; BONE MARROW CELLS; CHOLINESTERASES; CYCLOPHOSPHAMIDE; DNA; DNA DAMAGE; ERYTHROCYTES; MALE; MELATONIN; MICE; MICRONUCLEUS TESTS; PEROXIDASE; PROTEINS; RNA;

EID: 41249089865     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2007.06.003     Document Type: Article

References (43)

1. Tan D.X., Reiter R.J., Manchester L.C., Yan M.T., El-Sawi M., Sainz R.M., Mayo J.C., Kohen R., Allegra M., and Hardeland R. Curr. Top. Med. Chem. 2 (2002) 181-197
2. Jou M.J., Peng T.I., Reiter R.J., Jou S.B., Wu H.Y., and Wen S.T. J. Pineal Res. 37 (2004) 55-70
3. Majsterek I., Gloc E., Blasiak J., and Reiter R.J. J. Pineal Res. 38 (2005) 254-263
4. Rodriguez C., Mayo J.C., Sainz R.M., Antolin I., Herrera F., Martin V., and Reiter R.J. J. Pineal Res. 36 (2004) 1-9
5. Tomas-Zapico C., and Coto-Montes A. J. Pineal Res. 39 (2005) 99-104
6. Anderson D., Bishop J.B., Garner R.C., Ostrosky-Wegman P., and Selby P.B. Mutat. Res. 330 (1995) 115-181
7. Matsumoto F.E., and Cólus I.M.S. Genet. Mol. Biol. 23 2 (2000)
8. Musatov S.A., Anisimov V.N., André V., Vigreux C., Godard T., Gauduchon P., and Sichel F. Mutat. Res. 417 (1998) 75-84
9. Topal T., Ozates Y., Korkmaz A., Sadir S., Oter S., Coskun O., and Bilgic H. J. Pineal Res. 38 (2005) 272-277
10. Awara W.M., El-ghory M., El-nabi S.H., and Fadel W.A. Toxicology 125 (1998) 45-52
11. Sun L., Chen J., Takaki K., Johnson G., Ibaen L., Mahle C., Ryan E., and Xu C. Bioorg. Med. Chem. Lett. 14 (2004) 1197-1200
12. Takaki K.S., Mahle C.D., and Waston A.J. Curr. Pharm. Des. 3 (1997) 429-438
13. Ahmed H.H., Mannaa F., Elmegeed G.A., and Doss S.H. Bioorg. Med. Chem. 13 (2005) 1847-1857
14. Doss S.H., Mohareb R.M., Elmegeed G.A., and Louca N.A. Pharmazie 58 (2003) 607-613
15. Shih M., and Ke F. Bioorg. Med. Chem. 12 (2004) 4633-4643
16. Holla B.S., Malini K.V., Rao B.S., Sarojini B.K., and Kumari N.S. Eur. J. Med. Chem. 38 (2003) 313-318
17. Nobles W.L., and DeWitt Blanton C. J. Pharm. Sci. 53 (1964) 115-129
18. Ferreira I.C.F.R., Queiroz M.R.P., Vilas-Boas M., Estevinho L.M., Begouin A., and Gilbert K. Bioorg. Med. Chem. Lett. 16 (2006) 1384-1387
19. Sa{ogonek}czewski J., Brzozowski Z., Sa{ogonek}czewski F., Bendnarski P.J., Liebeke M., and Gdaniec M. Bioorg. Med. Chem. Lett. 16 (2006) 3663-3667
20. Daiber A., August M., Baldus S., Wendt M., Oelze M., Sydow K., Kleschyov A.L., and Munzel T. Free Radic. Biol. Med. 36 (2004) 101-111
21. Ostby O.B., Gundersen L.L., Rise F., Antonsen O., Fosnes K., Larsen V., Bast A., Custers I., and Haenen G.R. Arch. Pharm. (Weinheim) 334 (2001) 21-24
22. Heddle J.A., Hite M., Kirkhart B., Mavournin K., MacGregor J.T., Newell G.W., and Salamone M.F. Mutat. Res. 123 (1983) 61-118
23. Brawn K., and Fridovich I. Arch. Biochem. Biophys. 206 (1981) 414-419
24. Lown J.W., Joshua A.V., and Chen H.H. In: McBrien D.C.H., and Slater T.F. (Eds). Free Radicals, Lipid Peroxidation and Cancer (1982), Academic Press, New York 305-328
25. Halliwell B., and Gutteridge J.M.C. Biochem. J. 219 (1984) 1-14
26. Sewerynek E., Ortiz G.G., Reiter R.J., Pablos M.I., Melchiorri D., and Daniels W.M.U. Endocrinology 117 (1996) 183-188
27. Tan D.X., Chen L.D., Poeggeler B., Manchester L.C., and Reiter R.J. Endocr. J. 1 (1993) 57-60
28. Pieri C., Moroni F., Marra M., Marcheselli F., and Recchioni R. Arch. Gerontol. Geriatr. 20 (1995) 159-165
29. Melchiorri D., Reiter R.J., Attia A.M., Hara M., Burgos A., and Nistico G. Life Sci. 56 (1995) 83-89
30. Winiarska K., Fraczyk T., Malinska D., Drozak J., and Bryla J. J. Pineal Res. 40 (2006) 168-176
31. Barlow-Walden L.R., Reiter R.J., Abe M., Pablos M., Menendez-Pelaez A., Chen L.-D., and Poeggeler B. Neurochem. Int. 26 (1995) 497-502
32. Poeggeler B., Reiter R.J., Hardeland R., Sewerynek E., Melchiorri D., and Barlow-Walden L.R. Neuroendocrinol. Lett. 17 (1995) 87-92
33. Zavodnik I.B., Lapshina E.A., Zavodnik L.B., Labieniec M., Bryszewska M., and Reiter R.J. Mutat. Res. 559 (2004) 39-48
34. Meotti F.C., Silva D.O., Dos Santos A.R.S., Zeni G., Rocha J.B.T., and Nogueria C.W. Environ. Toxicol. Pharmacol. 37 (2003) 37-44
35. Menendez-Pelaez A., and Reiter R.J. J. Pineal. Res. 15 (1993) 59-69
36. De Salvia R., Fiore M., Aglitti T., Festa F., Ricordy R., and Cozzi R. Mutagenesis 14 (1999) 107-112
37. Adler I.D. Cytogenetic tests in mammals. In: Venitt S., and Parry J.M. (Eds). Mutagenicity Testing: A Practical Approach (1984), IRI Press, Oxford 275-306
38. Dische Z. Colour reactions of nucleic acid components. In: Chargall E., and Davidson J.M. (Eds). The Nucleic Acids vol. 1 (1955), Academic Press, New York 270-284
39. Peares A.G.E. Histochemistry Theoretical and Applied. Analytical Technology. fourth ed. vol. 2 (1985), Churchill Livingston, Edinburg, London, Melbourne and New York
40. Schneider W.C. Determination of acid in tissues by pentose analysis. In: Colowick S.P., and Kaplan N.O. (Eds). Method Enzymology (1957), Academic Press, New York 680-684
41. Peters T. Clin. Chem. 14 (1968) 1147-1159
42. Jakobs D.S., Kasten J.R.B.L., Demmott W.R., and Wolfson W.L. Laboratory Test Handbook. second ed. (1990), Lexi-Comp and Williams & Wilkins
43. Miranda M.V., Fernandez Lahor H.M., and Cascone O. Appl. Biochem. Biotechnol. 57 (1995) 2368-2375