The death of transcriptional chauvinism in the control and regulation of cardiac contractility

Annals of the New York Academy of Sciences

Volumn 1123, Issue , 2008, Pages 1-9

  Sadayappan, Sakthivel ^a   Robbins, Jeffrey ^a,b  

^a UNIVERSITY OF CINCINNATI   (United States)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Cardiac myosin binding protein C; Hypertrophy; Phosphorylation; Signaling

Indexed keywords

CIS TRANS ISOMERASE; MYOSIN BINDING PROTEIN C; TRANSCRIPTOME;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CONFERENCE PAPER; DNA SEQUENCE; GENE INTERACTION; GENETIC TRANSCRIPTION; HEART MUSCLE CONTRACTILITY; HOMEOSTASIS; IN VIVO STUDY; MOUSE; NONHUMAN; PROTEIN DEPHOSPHORYLATION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; PROTEIN TRANSPORT; RNA ANALYSIS; RNA STABILITY; RNA TRANSLATION;

MUS MUSCULUS;

EID: 41149176503     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1420.002     Document Type: Conference Paper

References (35)

1. FREIBURG, A. & M. GAUTEL. 1996. A molecular map of the interactions between titin and myosin-binding protein C. Implications for sarcomeric assembly in familial hypertrophic cardiomyopathy. Eur. J. Biochem. 235: 317-323.
2. OFFER, G., C. MOOS & R. STARR. 1973. A new protein of the thick filaments of vertebrate skeletal myofibrils. Extractions, purification and characterization. J. Mol. Biol. 74: 653-676.
3. WATKINS, H., D. CONNER, L. THIERFELDER, et al. 1995. Mutations in the cardiac myosin binding protein-C gene on chromosome 11 cause familial hypertrophic cardiomyopathy. Nat. Genet. 11: 434-437.
4. ASHRAFIAN, H. & H. WATKINS. 2007. Reviews of translational medicine and genomics in cardiovascular disease: new disease taxonomy and therapeutic implications cardiomyopathies: therapeutics based on molecular phenotype. J. Am. Coll. Cardiol. 49: 1251-1264.
5. AHMAD, F., J.G. SEIDMAN & C.E. SEIDMAN. 2005. The genetic basis for cardiac remodeling. Annu. Rev. Genomics Hum. Genet. 6: 185-216.
6. EINHEBER, S. & D.A. FISCHMAN. 1990. Isolation and characterization of a cDNA clone encoding avian skeletal muscle C-protein: an intracellular member of the immunoglobulin superfamily. Proc. Natl. Acad. Sci. USA 87: 2157-2161.
7. SEILER, S.H., D.A. FISCHMAN & L.A. LEINWAND. 1996. Modulation of myosin filament organization by c-protein family members. Mol. Biol. Cell. 7: 113-127.
8. WINEGRAD, S. 2000. Myosin binding protein C, a potential regulator of cardiac contractility. Circ. Res. 86: 6-7.
9. GAUTEL, M., O. ZUFFARDI, A. FREIBURG, et al. 1995. Phosphorylation switches specific for the cardiac isoform of myosin binding protein-C: a modulator of cardiac contraction? EMBO J. 14: 1952-1960.
10. KUNST, G., K.R. KRESS, M. GRUEN, et al. 2000. Myosin binding protein C, a phosphorylation-dependent force regulator inmuscle that controls the attachment of myosin heads by its interaction withmyosin S2. Circ. Res. 86: 51-58.
11. WEISBERG, A. & S. WINEGRAD. 1996. Alteration of myosin cross-bridges by phosphorylation of myosin-binding protein C in cardiac muscle. Proc. Natl. Acad. Sci. USA 93: 8999-9003.
12. LEVINE, R., A. WEISBERG, I. KULIKOVSKAYA, et al. 2001. Multiple structures of thick filaments in resting cardiac muscle and their influence on cross-bridge interactions. Biophys. J. 81: 1070-1082.
13. KULIKOVSKAYA, I., G. MCCLELLAN, J. FLAVIGNY, et al. 2003. Effect of MyBP-C Binding to actin on contractility in heart muscle. J. Gen. Physiol. 122: 761-774.
14. GARVEY, J.L., E.G. KRANIAS & R.J. SOLARO. 1988. Phosphorylation of C-protein, troponin I and phospholamban in isolated rabbit hearts. Biochem. J. 249: 709-714.
15. VENEMA, R.C. & J.F. KUO. 1993. Protein kinase C-mediated phosphorylation of troponin I and C-protein in isolated myocardial cells is associated with inhibition of myofibrillar actomyosin MgATPase. J. Biol. Chem. 268: 2705-2711.
16. YANG, Q., A. SANBE, H. OSINSKA, et al. 1998. Amouse model of myosin binding protein C human familial hypertrophic cardiomyopathy. J. Clin Invest. 102: 1292-1300.
17. YANG, Q., A. SANBE, H. OSINSKA, et al. 1999. In vivo modeling of myosin binding protein C familial hypertrophic cardiomyopathy. Circ. Res. 85: 841-847.
18. MCCONNELL, B.K., K.A. JONES, D. FATKIN, et al. 1999. Dilated cardiomyopathy in homozygous myosin-binding protein-C mutant mice. J. Clin. Invest. 104: 1235-1244.
19. HAHN, H.S., Y. MARREEZ, A. ODLEY, et al. 2003. Protein kinase Calpha negatively regulates systolic and diastolic function in pathological hypertrophy. Circ.Res. 93: 1111-1119.
20. SUMANDEA, M.P., E.M. BURKART, T. KOBAYASHI, et al. 2004. Molecular and integrated biology of thin filament protein phosphorylation in heart muscle. Ann. N.Y. Acad. Sci. 1015: 39-52.
21. DECKER, R.S., M.L. DECKER, I. KULIKOVSKAYA, et al. 2005. Myosin-binding protein C phosphorylation, myofibril structure, and contractile function during low-flow ischemia. Circulation 111: 906-912.
22. MOLKENTIN, J.D., J.R. LU, C.L. ANTOS, et al. 1998. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell 93: 215-228.
23. ARBER, S., J.J. HUNTER, J. ROSS, JR., et al. 1997. MLP-deficient mice exhibit a disruption of cardiac cytoarchitectural organization, dilated cardiomyopathy, and heart failure. Cell 88: 393-403.
24. KRENZ, M. & J. ROBBINS. 2004. Impact of beta-myosin heavy chain expression on cardiac function during stress. J. Am. Coll. Cardiol. 44: 2390-2397.
25. KRENZ, M., A. SANBE, F. BOUYER-DALLOZ, et al. 2003. Analysis ofmyosin heavy chain functionality in the heart. J. Biol. Chem. 278: 17466-17474.
26. PALERMO, J., J. GULICK, M. COLBERT, et al. 1996. Transgenic remodeling of the contractile apparatus in the mammalian heart. Circ. Res. 78: 504-509.
27. MCCLELLAN, G., I. KULIKOVSKAYA & S. WINEGRAD. 2001. Changes in cardiac contractility related to calcium-mediated changes in phosphorylation of myosin-binding protein C. Biophys. J. 81: 1083-1092.
28. VAN DER VELDEN, J., Z. PAPP, R. ZAREMBA, et al. 2003. Increased Ca2+-sensitivity of the contractile apparatus in end-stage human heart failure results from altered phosphorylation of contractile proteins. Cardiovasc. Res. 57: 37-47.
29. NEUMANN, J. 2002. Altered phosphatase activity in heart failure, influence on Ca2+ movement. Basic Res Cardiol. 97(Suppl 1): I91-95.
30. FLASHMAN, E., C. REDWOOD, J. MOOLMAN- SMOOK, et al. 2004. Cardiac myosin binding protein C: its role in physiology and disease. Circ. Res. 94: 1279-1289.
31. SQUIRE, J.M., P.K. LUTHER & C. KNUPP. 2003. Structural evidence for the interaction of C-protein (MyBP-C) with actin and sequence identification of a possible actin-binding domain. J. Mol. Biol. 331: 713-724.
32. SADAYAPPAN, S., J. GULICK, H. OSINSKA, et al. 2005. Cardiac myosin-binding protein-C phosphorylation and cardiac function. Circ. Res. 97: 1156-1163.
33. WEISBERG, A. & S. WINEGRAD. 1998. Relation between crossbridge structure and actomyosin ATPase activity in rat heart. Circ. Res. 83: 60-72.
34. SADAYAPPAN, S., H. OSINSKA, R. KLEVITSKY, et al. 2006. Cardiac myosin binding protein C phosphorylation is cardioprotective. Proc. Natl. Acad. Sci. USA 103: 16918-16923.
35. KULIKOVSKAYA, I., G. MCCLELLAN, R. LEVINE, et al. 2003. Effect of extraction of myosin binding protein C on contractility of rat heart. Am. J. Physiol. Heart Circ. Physiol. 285: H857-865.