Robust Score Statistics for QTL Linkage Analysis

American Journal of Human Genetics

Volumn 82, Issue 3, 2008, Pages 567-582

  Bhattacharjee, Samsiddhi ^a   Kuo, Chia Ling ^a   Mukhopadhyay, Nandita ^a   Brock, Guy N ^b   Weeks, Daniel E ^a   Feingold, Eleanor ^a  

^a UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^b UNIVERSITY OF LOUISVILLE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; GENETIC VARIABILITY; MATHEMATICAL ANALYSIS; PEDIGREE ANALYSIS; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; QUANTITATIVE TRAIT LOCUS MAPPING; SIMULATION; BIOLOGICAL MODEL; CHROMOSOME MAP; COMPUTER SIMULATION; GENETIC LINKAGE; HUMAN; METHODOLOGY; PEDIGREE;

CHROMOSOME MAPPING; COMPUTER SIMULATION; HUMANS; LINKAGE (GENETICS); MODELS, GENETIC; PEDIGREE; QUANTITATIVE TRAIT LOCI;

EID: 41149167107     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ajhg.2007.11.012     Document Type: Article

References (21)

1. Amos C.I. Robust variance-components approach for assessing genetic linkage in pedigrees. Am. J. Hum. Genet. 54 (1994) 535-543
2. Almasy L., and Blangero J. Multipoint quantitative-trait linkage analysis in general pedigrees. Am. J. Hum. Genet. 62 (1998) 1198-1211
3. Haseman J.K., and Elston R.C. The investigation of linkage between a quantitative trait and a marker locus. Behav. Genet. 2 (1972) 3-19
4. Allison D.B., Neale M.C., Zannolli R., Schork N.J., Amos C.I., and Blangero J. Testing the robustness of the likelihood-ratio test in a variance-component quantitative-trait loci-mapping procedure. Am. J. Hum. Genet. 65 (1999) 531-544
5. Tang H.K., and Siegmund D. Mapping quantitative trait loci in oligogenic models. Biostatistics 2 (2001) 147-162
6. Wang K., and Huang J. A score-statistic approach for the mapping of quantitative-trait loci with sibships of arbitrary size. Am. J. Hum. Genet. 70 (2002) 412-424
7. Putter H., Sandkuijl L.A., and van Houwelingen J.C. Score test for detecting linkage to quantitative traits. Genet. Epidemiol. 22 (2002) 345-355
8. Lebrec J., Putter H., and Houwelingen J.C. Score test for detecting linkage to complex traits in selected samples. Genet. Epidemiol. 27 (2004) 97-108
9. Wang K. A likelihood approach for quantitative-trait-locus mapping with selected pedigrees. Biometrics 61 (2005) 465-473
10. Peng J., and Siegmund D. QTL mapping under ascertainment. Ann. Hum. Genet. 70 (2006) 867-881
11. Sham P.C., and Purcell S. Equivalence between Haseman-Elston and variance-components linkage analyses for sib pairs. Am. J. Hum. Genet. 68 (2001) 1527-1532
12. Sham P.C., Purcell S., Cherny S.S., and Abecasis G.R. Powerful regression-based quantitative-trait linkage analysis of general pedigrees. Am. J. Hum. Genet. 71 (2002) 238-253
13. Chen W.M., Broman K.W., and Liang K.Y. Quantitative trait linkage analysis by generalized estimating equations: unification of variance components and Haseman-Elston regression. Genet. Epidemiol. 26 (2004) 265-272
14. Chen W.M., Broman K.W., and Liang K.Y. Power and robustness of linkage tests for quantitative traits in general pedigrees. Genet. Epidemiol. 28 (2005) 11-23
15. T. Cuenco K., Szatkiewicz J.P., and Feingold E. Recent advances in human quantitative-trait-locus mapping: comparison of methods for selected sibling pairs. Am. J. Hum. Genet. 73 (2003) 863-873
16. Szatkiewicz J.P., T. Cuenco K., and Feingold E. Recent advances in human quantitative-trait-locus mapping: comparison of methods for discordant sibling pairs. Am. J. Hum. Genet. 73 (2003) 874-885
17. Tang, H.K. (2000). Using variance components to map quantitative trait loci in humans. PhD thesis, Stanford University, Stanford, California.
18. Wang K., and Huang J. Score test for mapping quantitative-trait loci with sibships of arbitrary size when the dominance effect is not negligible. Genet. Epidemiol. 23 (2002) 398-412
19. Sengul H., Bhattacharjee S., Feingold E., and Weeks D.E. The elusive goal of pedigree weights. Genet. Epidemiol. 31 (2007) 51-65
20. Sham P.C., Zhao J.H., Cherny S.S., and Hewitt J.K. Variance-components QTL linkage analysis of selected and non-normal samples: conditioning on trait values. Genet. Epidemiol. 19 Suppl 1 (2000) S22-S28
21. Diao G., and Lin D.Y. A powerful and robust method for mapping quantitative trait loci in general pedigrees. Am. J. Hum. Genet. 77 (2005) 97-111