The elusive goal of pedigree weights

Genetic Epidemiology

Volumn 31, Issue 1, 2007, Pages 51-65

  Sengul, Haydar ^a   Bhattacharjee, Samsiddhi ^a   Feingold, Eleanor ^a   Weeks, Daniel E ^a,b  

^a UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Genetic models; Linkage; Pedigree weights; Power

Indexed keywords

ALLELE; ARTICLE; DISEASE SIMULATION; GENETIC MODEL; LINKAGE ANALYSIS; NONPARAMETRIC TEST; PEDIGREE; PEDIGREE ANALYSIS; PEDIGREE WEIGHTING SCHEME; POWER ANALYSIS; STANDARDIZATION; STATISTICAL ANALYSIS;

CHROMOSOME MAPPING; COMPUTER SIMULATION; LINKAGE (GENETICS); MODELS, GENETIC; MODELS, STATISTICAL; PEDIGREE; RECOMBINATION, GENETIC; STATISTICS, NONPARAMETRIC;

EID: 33845943387     PISSN: 07410395     EISSN: 10982272     Source Type: Journal    
DOI: 10.1002/gepi.20188     Document Type: Article

References (17)

1. Abel L, Alcais A, Mallet A. 1998. Comparison of four sib-pair linkage methods for analyzing sibships with more than two affecteds: interest of the binomial maximum likelihood approach. Genet Epidemiol 15:371-390.
2. Greenwood CM, Bull SB. 1999. Down-weighting of multiple affected sib pairs leads to biased likelihood-ratio tests, under the assumption of no linkage. Am J Hum Genet 64:1248-1252.
3. Gudbjartsson DF, Jonasson K, Frigge ML, Kong A. 2000. Allegro, a new computer program for multipoint linkage analysis. Nat Genet 25:12-13.
4. Hodge SE. 1984. The information contained in multiple sibling pairs. Genet Epidemiol 1:109-122.
5. Hossjer O. 2003. Assessing accuracy in linkage analysis by means of confidence regions. Genet Epidemiol 25:59-72.
6. Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES. 1996. Parametric and nonparametric linkage analysis: a unified multipoint approach. Am J Hum Genet 58:1347-1363.
7. Lange K. 1997. Mathematical and Statistical Methods for Genetic Analysis. New York: Springer-Verlag.
8. Lange K, Weeks D, Boehnke M. 1988. Programs for pedigree analysis: MENDEL, FISHER, and dGENE. Genet Epidemiol 5:471-472.
9. McPeek MS. 1999. Optimal allele-sharing statistics for genetic mapping using affected relatives. Genet Epidemiol 16:225-249.
10. Risch N. 1990a. Linkage strategies for genetically complex traits. I. Multilocus models. Am J Hum Genet 46:222-228.
11. Risch N. 1990b. Linkage strategies for genetically complex traits. II. The power of affected relative pairs. Am J Hum Genet 46:229-241.
12. Risch N. 1990c. Linkage strategies for genetically complex traits. III. The effect of marker polymorphism on analysis of affected relative pairs. Am J Hum Genet 46:242-253.
13. Sham PC, Zhao JH, Curtis D. 1997. Optimal weighting scheme for affected sib-pair analysis of sibship data. Ann Hum Genet 61:61-69.
14. Sobel E, Lange K. 1996. Descent graphs in pedigree analysis: applications to haplotyping, location scores, and marker-sharing statistics. Am J Hum Genet 58:1323-1337.
15. Suarez BK, Hodge SE. 1979. A simple method to detect linkage for rare recessive diseases: an application to juvenile diabetes. Clin Genet 15:126-136.
16. Teng J, Siegmund D. 1997. Combining information within and between pedigrees for mapping complex traits. Am J Hum Genet 60:979-992.
17. Whittemore AS, Halpern J. 1994. A class of tests for linkage using affected pedigree members. Biometrics 50:118-127.