Calcium oxalate crystals in acute ethylene glycol poisoning: A confocal laser scanning microscope study in a fatal case

Clinical Toxicology

Volumn 46, Issue 4, 2008, Pages 322-324

  Pomara, Cristoforo ^a   Fiore, Carmela ^a   D'Errico, Stefano ^a   Riezzo, Irene ^a   Fineschi, Vittorio ^a  

^a UNIVERSITY OF FOGGIA   (Italy)

Author keywords

Calcium oxalate crystals; Confocal microscopy; Ethylene glycol; Fatal case; Poisoning; Urine analysis

Indexed keywords

CALCIUM OXALATE; ETHYLENE GLYCOL; SUCCINATE DEHYDROGENASE;

ADULT; ALCOHOL INTOXICATION; ARTICLE; AUTOPSY; BLOOD LEVEL; CASE REPORT; CAUSE OF DEATH; ENZYME ACTIVITY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; INTRACELLULAR TRANSPORT; KIDNEY CELL; KIDNEY FAILURE; KIDNEY NECROSIS; KIDNEY TUBULE EPITHELIUM; LASER MICROSCOPY; MALE; METABOLIC ACIDOSIS; MITOCHONDRIAL RESPIRATION; NEPHROTOXICITY; URINALYSIS;

ACIDOSIS; ADULT; BIOTRANSFORMATION; CALCIUM OXALATE; ETHYLENE GLYCOL; FATAL OUTCOME; HUMANS; KIDNEY FAILURE, ACUTE; KIDNEY TUBULES, PROXIMAL; MALE; MICROSCOPY, CONFOCAL; NECROSIS;

EID: 41149156436     PISSN: 15563650     EISSN: 15569519     Source Type: Journal    
DOI: 10.1080/15563650701419011     Document Type: Article

References (12)

1. Froberg K, Dorion RP, McMartin KE. The role of calcium oxalate crystal deposition in cerebral vessels during ethylene glycol poisoning. Clin Toxicol 2006; 44:315-318.
2. Jacobsen D. Ethylene Glycol and other Glycols. In: Brent J, Wallace KL, Burkhart KK, Phillips SD, Donovan JW, eds. Critical Care toxicology. Diagnosis and management of the critically poisoned patient. Philadelphia, USA: Elsevier Mosby, 2005:777-790.
3. Corley RA, Meek ME, Carney EW. Mode of action: oxalate crystalinduced renal tubule degeneration and glycolic acid-induced dysmorphogenesis-renal and developmental effects of ethylene glycol. Crit Rev Toxicol 2005; 35:691-702.
4. McMartin KE, Wallace KB. Calcium oxalate monohydrate, a metabolite of ethylene glycol, is toxic for rat renal mitochondrial function. Toxicol Sci 2005; 84:195-200.
5. Eder AF, McGrath CM, Dowdy YG, Tomaszewski JE, Rosenberg FM, Wilson RB, Wolf BA, Shaw LM. Ethylene glycol poisoning: Toxicokinetic and analytical factors affecting laboratory diagnosis. Clin Chem 1998; 44:168-177.
6. Guo C, McMartin KE. The cytotoxicity of oxalate, metabolite of ethylene glycol, is due to calcium oxalate monohydrate formation. Toxicol 2005; 208:347-355.
7. Lewin-Smith MR, Kalasinsky VF, Mullick FG. Correspondence Re: C. Guo, K.E. McMartin, The cytotoxicity of oxalate, metabolite of ethylene glycol, is due to calcium oxalate monohydrate formation. Toxicology 2006; 222:160-161.
8. Yamaguchi S, Wiessner JH, Hasegawa AT, Hung LY, Mandel GS, Mandel NS. Study of a rat model for calcium oxalate crystal formation without severe renal damage in selected conditions. Int J Urol 2005; 12:290-298.
9. Khan SR, Thamilselvan S. Nephrolithiasis: A consequence of renal epithelial cell exposure to oxalate and calcium oxalate crystals. Mol Urol 2000; 4:305-312.
10. Ebisuno S, Kohjimoto Y, Tamura M, Inagaki T, Ohkawa T. Histological observations of the adhesion and endocytosis of calcium oxalate crystals in MDCK cells and in rat and human kidney. Urol Int 1997; 58:227-231.
11. Khan SR. Hyperoxaluria-induced oxidative stress and antioxidants for renal protection. Urol Res 2005; 33:349-357.
12. Pizon AF, Brooks DE. Hyperosmolality: another indication for hemodialysis following acute ethylene glycol poisoning. Clin Toxicol 2006; 44:181-183.