GADD34 gene restores virulence in viral vector used in experimental stroke study

Journal of Cerebral Blood Flow and Metabolism

Volumn 28, Issue 4, 2008, Pages 747-751

  McCabe, Christopher ^a   White, Fiona ^a,b   Brown, S Moira ^b   Macrae, I Mhairi ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b SOUTHERN GENERAL HOSPITAL   (United Kingdom)

Author keywords

ET 1; GADD34; HSV1716; Stroke

Indexed keywords

GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 34; HSV 1716; NEUROPROTECTIVE AGENT; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG EFFECT; ENCEPHALITIS; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MALE; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; STROKE; VIRUS REPLICATION; VIRUS VIRULENCE;

ANIMALS; ANTIGENS, DIFFERENTIATION; BRAIN INFARCTION; BRAIN ISCHEMIA; CELL CYCLE PROTEINS; DISEASE MODELS, ANIMAL; GENETIC VECTORS; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED C57BL; SIMPLEXVIRUS; STROKE; VIRULENCE;

EID: 41149141902     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.jcbfm.9600565     Document Type: Article

References (14)

1. Blais JD, Filipenko V, Bi M, Harding HP, Ron D, Koumenis C, Wouters BG, Bell JC (2004) Activating transcription factor 4 is translationally regulated by hypoxic stress. Mol Cell Biol 24:7469-82
2. Brown SM, Harland J, MacLean AR, Podlech J, Clements JB (1994) Cell type and cell state determine differential in vitro growth of non-neurovirulent ICP34.5-negative-herpes simplex virus types 1 and 2. J Gen Virol 75:2367-77
3. Cheng G, Feng Z, He B (2005) Herpes simplex virus 1 infection activates the endoplasmic reticulum resident kinase PERK and mediates eIF-2alpha dephosphorylation by the gamma(1)34.5 protein. J Virol 79:1379-88
4. Chou J, Roizman B (1994) Herpes simplex virus 1 gamma(1)34.5 gene function, which blocks the host response to infection, maps in the homologous domain of the genes expressed during growth arrest and DNA damage. Proc Natl Acad Sci USA 91:5247-51
5. Doutheil J, Althausen S, Gissel C, Paschen W (1999) Activation of MYD116 (gadd34) expression following transient forebrain ischemia of rat: implications for a role of disturbances of endoplasmic reticulum calcium homeostasis. Brain Res Mol Brain Res 63:225-32
6. Garcia L, Burda J, Hrehorovska M, Burda R, Martin ME, Salinas M (2004) Ischaemic preconditioning in the rat brain: effect on the activity of several initiation factors, Akt and extracellular signal-regulated protein kinase phosphorylation, and GRP78 and GADD34 expression. J Neurochem 88:136-47
7. He B, Gross M, Roizman B (1997) The gamma(1)34.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1alpha to dephosphorylate the alpha subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by double-stranded RNA-activated protein kinase. Proc Natl Acad Sci USA 94:843-8
8. Hollander MC, Zhan Q, Bae I, Fornace AJ (1997) Mammalian GADD34, an apoptosis- and DNA damage-inducible gene. J Biol Chem 272:13731-7
9. Imai H, Harland J, McCulloch J, Graham DI, Brown SM, Macrae IM (2002) Specific expression of the cell cycle regulation proteins, GADD34 and PCNA, in the peri-infarct zone after focal cerebral ischaemia in the rat. Eur J Neurosci 15:1929-36
10. Kojima E, Takeuchi A, Haneda M, Yagi A, Hasegawa T, Yamaki K, Takeda K, Akira S, Shimokata K, Isobe K (2003) The function of GADD34 is a recovery from a shutoff of protein synthesis induced by ER stress: elucidation by GADD34-deficient mice. FASEB J 17:1573-5
11. McKay EM, McVey B, Marsden HS, Brown SM, MacLean AR (1993) The herpes simplex virus type 1 strain 17 open reading frame RL1 encodes a polypeptide of apparent M(r) 37K equivalent to ICP34.5 of herpes simplex virus type 1 strain F. J Gen Virol 74:2493-7
12. Novoa I, Zeng H, Harding HP, Ron D (2001) Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha. J Cell Biol 153:1011-22
13. Paschen W (2003) Endoplasmic reticulum: a primary target in various acute disorders and degenerative diseases of the brain. Cell Calcium 34:365-83
14. White F, McCaig D, Brown SM, Graham DI, Harland J, Macrae IM (2004) Up-regulation of a growth arrest and DNA damage protein (GADD34) in the ischaemic human brain: implications for protein synthesis regulation and DNA repair. Neuropathol Appl Neurobiol 30:683-91