Multilevel finite element modeling for the prediction of local cellular deformation in bone

Biomechanics and Modeling in Mechanobiology

Volumn 7, Issue 2, 2008, Pages 151-159

  Deligianni, D D ^a   Apostolopoulos, C A ^a  

^a UNIVERSITY OF PATRAS   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMECHANICS; BONE; COMPUTER SIMULATION; FINITE ELEMENT METHOD; MICROSTRUCTURE;

BONE CELLS; EXTRACELLULAR MATRIX; LOCAL CELLULAR DEFORMATION; SINGLE LACUNA;

CELLS;

LACUNA;

ANISOTROPY; ARTICLE; BIOLOGICAL MODEL; COMPRESSIVE STRENGTH; COMPUTER SIMULATION; CYTOLOGY; ELASTICITY; FEMUR; FINITE ELEMENT ANALYSIS; MECHANICAL STRESS; MECHANOTRANSDUCTION; OSTEOBLAST; PHYSIOLOGY; WEIGHT BEARING;

ANISOTROPY; COMPRESSIVE STRENGTH; COMPUTER SIMULATION; ELASTICITY; FEMUR; FINITE ELEMENT ANALYSIS; MECHANOTRANSDUCTION, CELLULAR; MODELS, BIOLOGICAL; OSTEOBLASTS; STRESS, MECHANICAL; WEIGHT-BEARING;

EID: 41149129304     PISSN: 16177959     EISSN: 16822978     Source Type: Journal    
DOI: 10.1007/s10237-007-0082-1     Document Type: Article

References (38)

1. Adachi T, Sato K, Tomita Y (2003) Directional dependence of osteoblastic calcium response to mechanical stimuli. Biomech Model Mechanobiol 2(2):73-82
2. Ashman RB, Cowin SC, Van Buskirk WC, Rice JC (1984) A continuous wave technique for the measurement of the elastic properties of cortical bone. J Biomech 17:349-361
3. Brand RA, Stanford CM, Nicolella DP (2001) Primary adult human bone do not respond to tissue (continuum) level strains. J Orthop Sci 6:295-301
4. Breuls RGM, Sengers BG, Oomens CWJ, Bouten CVC, Baaijens FPT (2002) Predicting local cell deformations in engineered tissue constructs:a multilevel finite element approach. Trans ASME 124:198-207
5. Brighton CT, Fisher JR Jr, Levine SE, et al. (1996) The biochemical pathway mediating the proliferative response of bone cells to a mechanical stimulus. J Bone Joint Surg Am 78(9):1337-1347
6. Burr DB, Robling AG, Turner CH (2002) Effects of biomechanical stress on bones in animals. Bone 30:781-786
7. Cheung G, Zalzal P, Bhandari M, Spelt JK, Papini M (2004) Finite element analysis of a femoral retrograde intramedullary nail subject to gait loading. Med Eng Phys 26:93-108
8. Cowin SC, Moss-Salentijn L, Moss ML (1991) Candidates for the mechanosensory system in bone. J Biomech Eng 115:191-197
9. Deligianni DD, Tanner KE, Missirlis YF, Bonfield W (1991) Mechanical behavior of trabecular bone of the human femoral head in females. J Mat Sci Mater Med 2:168-175
10. Duda GN, Heller M, Albinger J, et al. (1998) Influence of muscle forces on femoral strain distribution. J Biomech 31:841-846
11. Gardner TN, Stoll T, Marks L, Mishra, Knothe Tate M (2000) The influence of mechanical stimulus on the pattern of tissue differentiation in a long bone fracture-an FEM study. J Biomech 33:415-425
12. Guilak F, Mow VC (2000) The mechanical environment of the chondrocyte:a biphasic finite element model of cell-matrix interactions in articular cartilage. J Biomech 33(12):1663-1673
13. Gururaja S, Kim HJ, Swan CC, Brand RA, Lakes RS (2005) Modeling deformation-induced fluid flow in cortical bone's canalicular-lacunar system. Ann Biomed Eng 33(1):7-25
14. Kaspar D, Seidl W, Neidlinger-Wilke C, Claes L (2000) In vitro effects of dynamic strain on the proliferative and metabolic activity of human osteoblasts. J Musculoskelet Neuronal Interact 1(2):161-164
15. Lanyon LE, Hampson WE Jr, Goodship AE, Shah JS (1975) Bone deformation recorded in vivo from strain gauges attached to the human tibial shaft. Acta Orthop Scand 46:256-268
16. Liebschner MAK, Keller TS (2005) Hydraulic strengthening affects the stiffness and strength of cortical bone. Ann Biomed Eng 33(1):26-38
17. Mak AFT, Zhang JD (2001) Numerical simulation of streaming potentials due to deformation-induced hierarchical flows in cortical bone. J Biomech Eng 123:66-70
18. Mak AFT, Huang DT, Zhang JD, Tong P (1997) Deformation-induced hierarchical flows and drag forces in bone canaliculi and matrix microporosity. J Biomech 30(1):11-18
19. McGarry JG, Klein-Nulend J, Mullender MG, Prendergast PJ (2005) A comparison of strain and fluid shear stress in stimulating bone cell responses: a computational and experimental study. FASEB J 19(3):482-484
20. Mullender M, El Haj AJ, Yang Y, van Duin MA, Burger EH, Klein-Nulend J (2004) Mechanotransduction of bone cells in vitro:mechanobiology of bone tissue. Med Biol Eng Comput 42:14-21
21. Nicolella DP, Lankford J (2002) Microstructural strain near osteocyte lacuna in cortical bone in vitro. J Musculoskelet Neuronal Interact 2(3):261-263
22. Owan I, Burr DB, Turner CH, et al. (1997) Mechanotransduction in bone:osteoblasts are more responsive to fluid forces than mechanical strain. Am J Physiol 273:C810-C815
23. Piekarski K, Munro M (1977) Transport mechanism operating between blood supply and osteocytes in long bones. Nature 269:80-82
24. Qin Y-X, Lin W, Rubin C (2002) The pathway of bone fluid flow as defined by in vivo intramedullary pressure and streaming potential measurements. J Biomed Eng 30:693-702
25. Reilly GC (2003) Observations of microdamage around osteocyte launae in bone. J Biomech 33:1131-1334
26. Reilly DT, Burnstein AH, Frankel VH (1974) The elastic modulus for bone. J Biomech 7:271-275
27. Swan CC, Lakes RS, Brand RA, Stewart KJ (2003) Micromechanically based poroelastic modeling of fluid flow in Haversian bone. J Biomech Eng 125(1):25-37
28. Taddei F, Cristofolini L, Martelli S, Gill HS, Viceconti M (2006) Subject specific finite element models of long bones:An in vitro evaluation of the overall accuracy. J Biomech 39(13):2457-2467
29. Tang LL, Wang YL, Pan J, Cai SX (2004) The effect of step-wise increased stretching on rat calvarial osteoblast collagen production. J Biomech 37(1):157-1661
30. Taylor ME, Tanner KE, Freeman MAR, Yettram AL (1996) Stress and strain distribution within the intact femur:compression or bending? Med Eng Phys 18(2):122-131
31. Turner CH, Anne V, Pidaparti RM (1997) A uniform strain criterion for trabecular bone adaptation:do continuum-level strain gradients drive adaptation? J Biomech 30:555-563
32. Viceconti M, Davinelli M, Taddei F, Cappello A (2004) Automatic generation of accurate subject-specific bone finite element models to be used in clinical studies. J Biomech 17:1597-1605
33. Wang L, Fritton SP, Cowin SC, Weinbaum S (1999) Fluid pressure relaxation depends upon osteonal microstructure:modeling an oscillatory bending experiment. J Biomech 32:663-672
34. Weinbaum S, Cowin SC, Zeng Y (1994) A model for the excitation of osteocytes by mechanical loadind - induced bone fluid shear stresses. J Biomech 27(3):339-360
35. Wirtz DC, Schiffers N, Pandorf T, Radermacher K, Weichert D, Forst R (2000) Critical evaluation of known bone material properties to realize anisotropic FE-simulation of the proximal femur. J Biomech 33(10):1325-1330
36. You J, Yellowley CE, Donahue HJ, et al. (2000) Substrate deformation levels associated with routine physical activity are less stimulatory to bone cells relative to loading-induced oscillatory fluid flow. J Biomech Eng 122:387-393
37. You J, Reilly GC, Zhen X, Yellowley CE, Chen Q, Donahue HJ, Jacobs CR (2001) Osteopontin gene regulation by oscillatory fluid flow via intracellular calcium mobilization and activation of mitogen-activated protein kinase in MC3T3-E1 osteoblasts. J Biol Chem 276:13365-13371
38. Zhang DS, Weinbaum S, Cowin SC (1998) Estimates of the peak pressures in bone pore water. J Biomech Eng 120(6):697-703