Identification of a cis-acting element of human dihydrofolate reductase mRNA

Biochemical and Biophysical Research Communications

Volumn 369, Issue 3, 2008, Pages 795-800

  Tai, Ningwen ^a,b   Schmitz, John C ^a,b   Chen, Tian min ^a,b   O'Neill, Michelle B ^a,b   Chu, Edward ^a,b  

^a YALE CANCER CENTER   (United States)

^b VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

Author keywords

cis acting element; Dihydrofolate reductase; RNA protein interaction; Translational regulation

Indexed keywords

CIS ACTING ELEMENT; DIHYDROFOLATE REDUCTASE; LUCIFERASE; MESSENGER RNA; RIBONUCLEOPROTEIN;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; GENE IDENTIFICATION; GENE REPRESSION; GENE SEQUENCE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VIVO STUDY; PRIORITY JOURNAL; PROTEIN RNA BINDING; REPORTER GENE;

BASE SEQUENCE; CELL LINE, TUMOR; GENE EXPRESSION REGULATION; GENES, REPORTER; HUMANS; LUCIFERASES, RENILLA; MOLECULAR SEQUENCE DATA; PROTEIN BIOSYNTHESIS; REGULATORY SEQUENCES, RIBONUCLEIC ACID; RNA, MESSENGER; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 41149124595     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.09.044     Document Type: Article

References (23)

1. Day D.A., and Tuite M.F. Post-transcriptional gene regulatory mechanisms in eukaryotes: an overview. J. Endocrinol. 157 (1998) 361-371
2. de Moor C.H., and Richter J.D. Translational control in vertebrate development. Int. Rev. Cytol. 203 (2001) 567-608
3. Lal A., Mazan-Mamczarz K., Kawai T., Yang X., Martindale J.L., and Gorospe M. Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs. EMBO J. 23 (2004) 3092-3102
4. Ch'ng J.L., Shoemaker D.L., Schimmel P., and Holmes E.W. Reversal of creatine kinase translational repression by 3′ untranslated sequences. Science 248 (1990) 1003-1006
5. Fahling M., Steege A., Perlewitz A., Nafz B., Mrowka R., Persson P.B., and Thiele B.J. Role of nucleolin in posttranscriptional control of MMP-9 expression. Biochim. Biophys. Acta 1731 (2005) 32-40
6. Gu W., and Hecht N.R. Translation of a testis-specific Cu/Zn superoxide dismutase (SOD-1) mRNA is regulated by a 65-kilodalton protein which binds to its 5′ untranslated region. Mol. Cell. Biol. 16 (1996) 4535-4543
7. Mazumder B., Seshadri V., and Fox P.L. Translational control by the 3′-UTR: the ends specify the means. Trends Biochem. Sci. 28 (2003) 91-98
8. Thomson A.M., Rogers J.T., and Leedman P.J. Iron-regulatory proteins, iron-responsive elements and ferritin mRNA translation. Int. J. Biochem. Cell Biol. 31 (1999) 1139-1152
9. Lin X., Parsels L.A., Voeller D.M., Allegra C.J., Maley G.F., Maley F., and Chu E. Characterization of a cis-acting regulatory element in the protein coding region of thymidylate synthase mRNA. Nucleic Acids Res. 28 (2000) 1381-1389
10. Reddy N.G., Hall J.C., Kochins J.G., and Perez F.M. Identification of novel RNA-binding proteins that interact in the coding region of protein D sense RNA in vitro. Biochem. Biophys. Res. Commun. 87 (1992) 318-324
11. McLaughlin B.A., Spencer C., and Eberwine J. CAG trinucleotide RNA repeats interact with RNA-binding proteins. Am. J. Hum. Genet. 59 (1996) 561-569
12. Spencer C.M., and Eberwine J. Cytoplasmic proteins interact with a translational control element in the protein-coding region of proopiomelanocortin mRNA. DNA Cell Biol. 18 (1999) 39-49
13. Chu E., Takimoto C.H., Voeller D.M., Grem J.L., and Allegra C.J. Specific binding of human dihydrofolate reductase protein to dihydrofolate reductase messenger RNA in vitro. Biochemistry 32 (1993) 4756-4760
14. Ercikan E., Banerjee D., Waltham M., Schnieders B., Scotto K.W., and Bertino J.R. Translational regulation of the synthesis of dihydrofolate reductase. Adv. Exp. Med. Biol. 338 (1993) 537-540
15. Ercikan-Abali E.A., Banerjee D., Waltham M.C., Skacel N., Scottto K.W., and Bertino J.R. Dihydrofolate reductase protein inhibits its own translation by binding to dihydrofolate reductase mRNA sequences within the coding region. Biochemistry 36 (1997) 12317-12322
16. Tai N., Ding Y., Schmitz J.C., and Chu E. Identification of critical amino acid residues on human dihydrofolate reductase protein that mediate RNA recognition. Nucleic Acids Res. 30 (2002) 4481-4488
17. Tai N., Schmitz J.C., Chen T., and Chu E. Characterization of a cis-acting element within the protein coding region of human dihydrofolate reductase mRNA. Biochem. J. 378 (2004) 999-1006
18. Tai N., Schmitz J.C., Liu J., Lin X., Bailly M., Chen T.M., and Chu E. Translational autoregulation of thymidylate synthase and dihydrofolate reductase. Front. Biosci. 9 (2004) 2521-2526
19. Banerjee D., Mayer-Kuckuk P., Capiaux G., Budak-Alpdogan T., Gorlick R., and Bertino J.R. Novel aspects of resistance to drugs targeted to dihydrofolate reductase and thymidylate synthase. Biochim. Biophys. Acta 1587 (2002) 164-173
20. Monie T.P., Greatorex J.S., Zacharias M., and Lever A.M. The human T-cell lymphotropic virus type-I dimerization initiation site forms a hairpin loop, unlike previously characterized retroviral dimerization motifs. Biochemistry 43 (2004) 6085-6090
21. McGuire J.J. Anticancer antifolates: current status and future directions. Curr. Pharm. Des. 9 (2003) 2593-2613
22. Blakley R.L., and Sorrentino B.P. In vitro mutations in dihydrofolate reductase that confer resistance to methotrexate: potential for clinical application. Hum. Mutat. 11 (1998) 259-263
23. Liu J., Schmitz J.C., Lin X., Tai N., Yan W., Farrell M., Bailly M., Chen T., and Chu E. Thymidylate synthase as a translational regulator of cellular gene expression. Biochim. Biophys. Acta 1587 (2002) 174-182