Disruption of phospholipase Cγ1 signalling attenuates cardiac tumor necrosis factor-α expression and improves myocardial function during endotoxemia

Cardiovascular Research

Volumn 78, Issue 1, 2008, Pages 90-97

  Peng, Tianqing ^a,b   Shen, E ^a,b   Fan, Jue ^a   Zhang, Yan ^a   Arnold, J Malcolm O ^b   Feng, Qingping ^a,b  

^a LAWSON HEALTH RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

Cardiomyocytes; Contractility; Cytokine; Phospholipase C; Sepsis

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; 1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 2,5 PYRROLIDINEDIONE; DIACYLGLYCEROL; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHOLIPASE C GAMMA1; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA; 1 (6 ((3 METHOXYESTRA 1,3,5(10) TRIEN 17 YL)AMINO)HEXYL) 1H PYRROLE 2,5 DIONE; 1-(6-((3-METHOXYESTRA-1,3,5(10)-TRIEN-17-YL)AMINO)HEXYL)-1H-PYRROLE-2,5-DIONE; 2 PYRROLIDONE DERIVATIVE; ESTRANE DERIVATIVE; INOSITOL 1,4,5 TRISPHOSPHATE; PHOSPHODIESTERASE INHIBITOR; PHOSPHOLIPASE C GAMMA; PLCG1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENDOTOXEMIA; ENZYME ANALYSIS; ENZYME PHOSPHORYLATION; GENE DELETION; HEART MUSCLE CELL; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEPSIS; ANIMAL; C57BL MOUSE; CARDIOMYOPATHY; CELL CULTURE; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENETIC TRANSFECTION; GENETICS; HEART CONTRACTION; METABOLISM; MOUSE MUTANT; PATHOPHYSIOLOGY; PHOSPHORYLATION; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

ANIMALS; ANIMALS, NEWBORN; CARDIOMYOPATHIES; CELLS, CULTURED; DIGLYCERIDES; DISEASE MODELS, ANIMAL; ENDOTOXEMIA; ESTRENES; INOSITOL 1,4,5-TRISPHOSPHATE; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; PHOSPHODIESTERASE INHIBITORS; PHOSPHOLIPASE C GAMMA; PHOSPHORYLATION; PYRROLIDINONES; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 41149108014     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvm100     Document Type: Article

References (45)

1. Angus DC, Wax RS. Epidemiology of sepsis: an update. Crit Care Med 2001;29(Suppl. 7):S109-S116.
2. Natanson C, Fink MP, Ballantyne HK, MacVittie TJ, Conklin JJ, Parrillo JE. Gram-negative bacteremia produces both severe systolic and diastolic cardiac dysfunction in a canine model that simulates human septic shock. J Clin Invest 1986;78:259-270.
3. Parrillo JE, Parker MM, Natanson C, Suffredini AF, Danner RL, Cunnion RE et al. Septic shock in humans. Advances in the understanding of pathogenesis, cardiovascular dysfunction, and therapy. Ann Intern Med 1990;113:227-242.
4. Natanson C, Eichenholz PW, Danner RL, Eichacker PQ, Hoffman WD, Kuo GC et al. Endotoxin and tumor necrosis factor challenges in dogs simulate the cardiovascular profile of human septic shock. J Exp Med 1989;169:823-832.
5. Suffredini AF, Fromm RE, Parker MM, Brenner M, Kovacs JA, Wesley RA et al. The cardiovascular response of normal humans to the administration of endotoxin. N Engl J Med 1989;321:280-287.
6. Parrillo JE, Burch C, Shelhamer JH, Parker MM, Natanson C, Schuette W. A circulating myocardial depressant substance in humans with septic shock. Septic shock patients with a reduced ejection fraction have a circulating factor that depresses in vitro myocardial cell performance. J Clin Invest 1985;76:1539-1553.
7. Peng T, Lu X, Lei M, Moe GW, Feng Q. Inhibition of p38 MAPK decreases myocardial TNF-alpha expression and improves myocardial function and survival in endotoxemia. Cardiovasc Res 2003;59:893-900.
8. Grandel U, Fink L, Blum A, Heep M, Buerke M, Kraemer HJ et al. Endotoxin-induced myocardial tumor necrosis factor-alpha synthesis depresses contractility of isolated rat hearts: evidence for a role of sphingosine and cyclooxygenase-2-derived thromboxane production. Circulation 2000;102:2758-2764.
9. Bozkurt B, Kribbs SB, Clubb FJ Jr, Michael LH, Didenko VV, Hornsby PJ et al. Pathophysiologically relevant concentrations of tumor necrosis factor-alpha promote progressive left ventricular dysfunction and remodeling in rats. Circulation 1998;97:1382-1391.
10. Oral H, Dorn GW 2nd, Mann DL. Sphingosine mediates the immediate negative inotropic effects of tumor necrosis factor-alpha in the adult mammalian cardiac myocyte. J Biol Chem 1997;272:4836-4842.
11. Peng T, Lu X, Feng Q. Pivotal role of gp91phox-containing NADH oxidase in lipopolysaccharide-induced tumor necrosis factor-alpha expression and myocardial depression. Circulation 2005;111:1637-1644.
12. Peng T, Lu X, Lei M, Feng Q. Endothelial nitric-oxide synthase enhances lipopolysaccharide-stimulated tumor necrosis factor-alpha expression via cAMP-mediated p38 MAPK pathway in cardiomyocytes. J Biol Chem 2003;278:8099-8105.
13. Rhee SG. Regulation of phosphoinositide-specific phospholipase C. Annu Rev Biochem 2001;70:281-312.
14. Rebecchi MJ, Pentyala SN. Structure, function, and control of phosphoinositide-specific phospholipase C. Physiol Rev 2000;80:1291-1335.
15. Zhang F, Zhao G, Dong Z. Phosphatidylcholine-specific phospholipase C and D in stimulation of RAW264.7 mouse macrophage-like cells by lipopolysaccharide. Int Immunopharmacol 2001;1:1375-1384.
16. Yamamoto T, Nakane T, Doi S, Osaki T. Lipopolysaccharide signal transduction in oral keratinocytes-involvement of CD59 but not CD14. Cell Signal 2003;15:861-869.
17. Dent MR, Dhalla NS, Tappia PS. Phospholipase C gene expression, protein content, and activities in cardiac hypertrophy and heart failure due to volume overload. Am J Physiol Heart Circ Physiol 2004;287:H719-H727.
18. Fan H, Teti G, Ashton S, Guyton K, Tempel GE, Halushka PV et al. Involvement of G(i) proteins and Src tyrosine kinase in TNFalpha production induced by lipopolysaccharide, group B Streptococci and Staphylococcus aureus. Cytokine 2003;22:126-133.
19. Tappia PS, Liu SY, Shatadal S, Takeda N, Dhalla NS, Panagia V. Changes in sarcolemmal PLC isoenzymes in postinfarct congestive heart failure: partial correction by imidapril. Am J Physiol 1999;277:H40-H49.
20. Ji QS, Winnier GE, Niswender KD, Horstman D, Wisdom R, Magnuson MA et al. Essential role of the tyrosine kinase substrate phospholipase C-g1 in mammalian growth and development. Proc Natl Acad Sci USA 1997;94:2999-3003.
21. Peng T, Lu X, Feng Q. NADH oxidase signaling induces cyclooxygenase-2 expression during lipopolysaccharide stimulation in cardiomyocytes. FASEB J 2005;19:293-295.
22. Shen E, Fan J, Chen R, Yee SP, Peng T. Phospholipase Cgamma1 signalling regulates lipopolysaccharide-induced cyclooxygenase-2 expression in cardiomyocytes. J Mol Cell Cardiol 2007;43:308-318.
23. Ramana K, Willis M, White M, Horton J, DiMaio J, Srivastava D et al. Endotoxin-induced cardiomyopathy and systemic inflammation in mice is prevented by aldose reductase inhibition. Circulation 2006;114:1838-1846.
24. Hong JH, Moon SJ, Byun HM, Kim MS, Jo H, Bae YS et al. Critical role of phospholipase Cgamma1 in the generation of H2O2-evoked [Ca2+i] oscillations in cultured rat cortical astrocytes. J Biol Chem 2006;281:13057-13067.
25. Lin X, Varnai P, Csordas G, Balla A, Nagai T, Miyawaki A et al. Control of calcium signal propagation to the mitochondria by inositol 1,4,5-trisphosphate-binding proteins. J Biol Chem 2005;280:12820- 12832.
26. Uchiyama T, Yoshikawa F, Hishida A, Furuichi T, Mikoshiba K. A novel recombinant hyperaffinity inositol 1,4,5-trisphosphate (IP(3)) absorbent traps IP(3), resulting in specific inhibition of IP(3)-mediated calcium signaling. J Biol Chem 2002;277:8106-8113.
27. Varnai P, Lin X, Lee SB, Tuymetova G, Bondeva T, Spat A et al. Inositol lipid binding and membrane localization of isolated pleckstrin homology (PH) domains. Studies on the PH domains of phospholipase C delta 1 and p130. J Biol Chem 2002;277:27412-27422.
28. Maeda N, Niinobe M, Mikoshiba K. A cerebellar Purkinje cell marker P400 protein is an inositol 1,4,5-trisphosphate (InsP3) receptor protein. Purification and characterization of InsP3 receptor complex. EMBO J 1990;9:61-67.
29. Yoshikawa F, Iwasaki H, Michikawa T, Furuichi T, Mikoshiba K. Trypsinized cerebellar inositol 1,4,5-trisphosphate receptor. Structural and functional coupling of cleaved ligand binding and channel domains. J Biol Chem 1999;274:316-327.
30. Vermassen E, Parys JB, Mauger JP. Subcellular distribution of the inositol 1,4,5-trisphosphate receptors: functional relevance and molecular determinants. Biol Cell 2004;96:3-17.
31. Taylor CW, Genazzani AA, Morris SA. Expression of inositol trisphosphate receptors. Cell Calcium 1999;26:237-251.
32. De Smedt H, Missiaen L, Parys JB, Bootman MD, Mertens L, Van Den Bosch L et al. Determination of relative amounts of inositol trisphosphate receptor mRNA isoforms by ratio polymerase chain reaction. J Biol Chem 1994;269:21691-21698.
33. Wang Y, Chen J, Taylor CW, Hirata Y, Hagiwara H, Mikoshiba K et al. Crucial role of type 1, but not type 3, inositol 1,4,5-trisphosphate (IP(3)) receptors in IP(3)-induced Ca(2+) release, capacitative Ca(2+) entry, and proliferation of A7r5 vascular smooth muscle cells. Circ Res 2001;88:202-209.
34. Wen R, Chen Y, Schuman J, Fu G, Yang S, Zhang W et al. An important role of phospholipase Cgamma1 in pre-B-cell development and allelic exclusion. EMBO J 2004;23:4007-4017.
35. Singal T, Dhalla NS, Tappia PS. Phospholipase C may be involved in norepinephrine-induced cardiac hypertrophy. Biochem Biophys Res Commun 2004;320:1015-1019.
36. Tappia PS, Asemu G, Aroutiounova N, Dhalla NS. Defective sarcolemmal phospholipase C signaling in diabetic cardiomyopathy. Mol Cell Biochem 2004;261:193-199.
37. Asemu G, Dhalla NS, Tappia PS. Inhibition of PLC improves postischemic recovery in isolated rat heart. Am J Physiol Heart Circ Physiol 2004;287:H2598-H2605.
38. Merx MW, Weber C. Sepsis and the heart. Circulation 2007;116:793-802.
39. Cowan DB, Noria S, Stamm C, Garcia LM, Poutias DN, del Nido PJ et al. Lipopolysaccharide internalization activates endotoxin-dependent signal transduction in cardiomyocytes. Circ Res 2001;88:491-498.
40. Marks AR. Cardiac intracellular calcium release channels: role in heart failure. Circ Res 2000;87:8-11.
41. Perez PJ, Ramos-Franco J, Fill M, Mignery GA. Identification and functional reconstitution of the type 2 inositol 1,4,5-trisphosphate receptor from ventricular cardiac myocytes. J Biol Chem 1997;272:23961- 23969.
42. Borgatta L, Watras J, Katz AM, Ehrlich BE. Regional differences in calcium-release channels from heart. Proc Natl Acad Sci USA 1991;88:2486-2489.
43. Geoghegan-Morphet N, Burger D, Lu X, Sathish V, Peng T, Sims SM et al. Role of neuronal nitric oxide synthase in lipopolysaccharide-induced tumor necrosis factor-alpha expression in neonatal mouse cardiomyocytes. Cardiovasc Res 2007;75:408-416.
44. Maass DL, White J, Sanders B, Horton JW. Role of cytosolic vs. mitochondrial Ca2+ accumulation in burn injury-related myocardial inflammation and function. Am J Physiol Heart Circ Physiol 2005;288:H744-H751.
45. Agell N, Bachs O, Rocamora N, Villalonga P. Modulation of the Ras/Raf/MEK/ERK pathway by Ca(2+), and calmodulin. Cell Signal 2002;14:649-654.