Rapid selective screening and determination of ephedrine alkaloids using GC-MS footnote mark

Phytochemical Analysis

Volumn 19, Issue 2, 2008, Pages 127-135

  Ranieri, Tracy L ^a   Ciolino, Laura A ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Ephedra; Ephedrine; Gas chromatography mass spectrometry; Ma huang; O TMS, N TFA derivatives; Pseudoephedrine

Indexed keywords

ALKALOIDS; CHLORINE COMPOUNDS; DIAGNOSIS; FOOD ADDITIVES; GAS CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES; NUTRITION; ORGANIC SOLVENTS; PLANT EXTRACTS; VITAMINS;

DERIVATIZATIONS; EPHEDRA; EPHEDRINE; EXTRACTION SOLVENTS; GASCHROMATOGRAPHY-MASS SPECTROMETRY; HERBAL EXTRACT; MA HUANG; O-TMS, N-TFA DERIVATIVE; PSEUDOEPHEDRINE; TRADITIONAL CHINESE MEDICINE;

DIETARY SUPPLEMENTS;

ALKALOID; CHLOROFORM; EPHEDRA EXTRACT; EPHEDRINE; METHYLEPHEDRINE; METHYLPSEUDOEPHEDRINE; NOREPHEDRINE; NORPSEUDOEPHEDRINE; PSEUDOEPHEDRINE; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; DERIVATIZATION; DIET SUPPLEMENTATION; DRUG DETERMINATION; DRUG SCREENING; DRUG STRUCTURE; EPHEDRA; GAS CHROMATOGRAPHY; LINEAR SYSTEM; MASS SPECTROMETRY; QUANTITATIVE ANALYSIS; REPRODUCIBILITY;

EPHEDRA;

EID: 41149104474     PISSN: 09580344     EISSN: 10991565     Source Type: Journal    
DOI: 10.1002/pca.1025     Document Type: Article

References (25)

1. Betz JM, Gay ML, Mossoba MM, Adams SA, Portz BS. 1997. Chiral gas chromatographic determination of ephedrine-type alkaloids in dietary supplements containing Ma Huang. J AOAC Int 80: 303-315.
2. Caveney S, Charlet DA, Freitag H, Maier-Stolte M, Starratt AN. 2001. New observations on the secondary chemistry of world Ephedra (Ephedraceae). Am J Bot 88: 1199-1208.
3. Coutts RT, Dawe R, Jones GR, Liu SF, Midha KK. 1980. Analysis of perfluoroacyl derivatives of ephedrine, pseudoephedrine and analogues by gas chromatography and mass spectrometry. J Chromatogr 190: 53-65.
4. Cui J, Zhou T, Zhang J, Lou Z. 1991. Analysis of alkaloids in Chinese Ephedra species by gas chromatographic methods. Phytochem AnaL 2: 116-119.
5. Flurer CL, Lin LA, Satzger RD, Wolnik KA. 1995. Determination of ephedrine compounds in nutritional supplements by cyclodextrin-modified capillary electrophoresis. J Chromatogr B Biomed Applic 669: 133-139.
6. Gay ML, White KD, Obermeyer WR, Betz JM, Musser SM. 2001. Determination of ephedrine - type alkaloids in dietary supplements by LC/MS using a stable-isotope labeled internal standard. J AOAC Int 84: 761-769.
7. Hurlbut JA, Carr JR, Singleton ER, Faul KC, Madson MR, Storey JM, Thomas TL. 1998. Solid-phase extraction cleanup and liquid chromatography with ultraviolet detection of ephedrine alkaloids in herbal products. J AOAC Int 81: 1121-1127.
8. Hurlbut JA, Martin WB. 2001. GC-MS confirmation of ephedrine and pseudoephedrine in herbal products. FDA-Lab Inform Bull 4253: 1-10.
9. Jian Z, Zhen T, Zhi-cen L. 1988. Simultaneous determination of six alkaloids in Ephedrae Herba by high performance liquid chromatography. Planta Med 54: 69-70.
10. Kondo N, Mikage M, Idaka K. 1999. Medico-botanical studies of Ephedra plants from the Himalayan region, Part III. Causitive factors of variation of alkaloid content in herbal stems. Nat Med 53: 194-200.
11. Li H, Ding M, Lv K, Yu J. 2001. Separation and determination of ephedrine alkaloids and tetramethylpyrazine in Ephedra sinica Stapf by gas chromatography-mass spectrometry. J Chromatogr Sci 39: 370-374.
12. Liu Y, Sheu S. 1992. Determination of ephedrine alkaloids by capillary electrophoresis. J Chromatogr 600: 370-372.
13. Liu Y, Sheu S. 1993. Determination of ephedrine and pseudoephedrine in Chinese herbal preparations by capillary electrophoresis. J Chromatogr 637: 219-233.
14. Liu Y, Sheu S, Chiou S, Chang H, Chen Y. 1993. A comparative study on commercial samples of Ephedrae Herba. Planta Med 59: 376-378.
15. Marchei E, Pellegrini M, Pacifici R, Zuccaro P, Pichini S. 2006. A rapid and simple procedure for the determination of ephedrine alkaloids in dietary supplements by gas chromatography-mass spectrometry. J Pharm Biomed Anal 41:1633-1641.
16. Niemann RA, Gay ML. 2003. Determination of ephedrine alkaloids and synephrine in dietary supplements by column-switching cation exchange high-performance liquid chromatography with scanning-wavelength ultraviolet and fluorescence detection. J Agric Food Chem 51: 5630-5638.
17. Okamura N, Miki H, Harada T, Yamashita S, Masaoka Y, Nakamoto Y, Tsuguma M, Yoshitomi H, Yagi A. 1999. Simulataneous determination of ephedrine, pseudoephedrine, norephedrine and methyl-ephedrine in Kampo medicines by high performance liquid chromatography. J Pharm Biomed Anal 20: 363-372.
18. Roman MC. 2004. Determination of ephedrine alkaloids in botanicals and dietary supplements by HPLC-UV: collaborative study. J AOAC Int 87: 1-24.
19. Sander LC, Sharpless KE, Satterfield MB, Ihara T, Phinney KW, Yen JH, Wise SA, Gay ML, Lam JW, McCooeye M, Gardner G, Fraser C, Sturgeon R, Roman M. 2005. Determination of ephedrine alkaloids In dietary supplement standard reference materials. Anal Chem 77: 3101-3112.
20. Shekelle PG, Hardy ML, Morton SC, Maglione M, Mojica WA, Suttorp MS, Rhodes SL, Jungvig L, Gagne J. 2003. Efficacy and safety of ephedra and ephedrine for weight loss and athletic performance. JAMA 289: 1537-1545.
21. Spyridaki MHE, Tsitsimpikou CJ, Panayotis SA, Costas GG. 2001. Determination of ephedrines in urine by gas chromatographymass spectrometry. J Chromatogr B 758: 311-314.
22. Tanaka T, Ohba K, Kawahara K, Sakei E. 1995. Comparison of the constituents of Ephedra herbs from various countries on ephedrine type alkaloids. Nat Med 49: 418-424.
23. The Pharmacopoeia Commission of PRC. 1992. Pharmacopoeia of the People's Republic of China (English Editian 1992). Guangdong Science and Technology Press: Guangzhou.
24. Trujillo W, Sorenson W. 2003. Determination of ephedrine alkaloids in dietary supplements and botanicals by liquid chromatography/tandem mass spectrometry: collaborative study. J AOAC Int 86: 657-668.
25. Van der Merwe PJ, Hendrikz SE. 1995. Identification of ephedrines as their carbon disulphide derivatives. J Chromatogr B 663: 160-166.