A novel thioredoxin reductase inhibitor inhibits cell growth and induces apoptosis in HL-60 and K562 cells

Journal of Zhejiang University: Science B

Volumn 9, Issue 1, 2008, Pages 16-21

  Peng, Zuo Fu ^a   Lan, Lin Xiang ^a   Zhao, Fang ^a   Li, Jing ^a   Tan, Qiang ^b   Yin, Han Wei ^c   Zeng, Hui Hui ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b PEKING UNIVERSITY FIRST HOSPITAL   (China)

^c PEKING UNIVERSITY   (China)

Author keywords

1,2 bis(1,2 benzisoselenazolone 3(2H) ketone) ethane (BBSKE); Apoptosis; Novel TrxR inhibitor; Thioredoxin reductase (TrxR)

Indexed keywords

1,2 [BIS(1,2 BENZOISOSELENAZOLONE 3(2H) KETONE)]ETHANE; CASPASE 3; CYCLOPHOSPHAMIDE; ENZYME INHIBITOR; PROTEIN BAX; PROTEIN BCL 2; THIOREDOXIN REDUCTASE; THIOREDOXIN REDUCTASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER GROWTH; CELL GROWTH; CELL STRAIN HL 60; CELL STRAIN K 562; CONTROLLED STUDY; EHRLICH ASCITES TUMOR; GROWTH INHIBITION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BICYCLO COMPOUNDS, HETEROCYCLIC; CELL PROLIFERATION; ENZYME INHIBITORS; HL-60 CELLS; HUMANS; K562 CELLS; ORGANOSELENIUM COMPOUNDS; PROTO-ONCOGENE PROTEINS C-BCL-2; THIOREDOXIN-DISULFIDE REDUCTASE;

MUS;

EID: 41149099226     PISSN: 16731581     EISSN: 18621783     Source Type: Journal    
DOI: 10.1631/jzus.B071605     Document Type: Article

References (26)

1. Andreani, A., Scapini, G., Galatulas, I., Bossa, R., 1983. Potential antitumor agents IX: Synthesis and antitumor activity of two analogues of ketocaine. J. Pharm. Sci., 72(7):814-815. [doi:10.1002/jps.2600720724]
2. Barral, A.M., Källström, R., Sander, B., Rosén, A., 2000. Thioredoxin, thioredoxin reductase and tumour necrosis factor-alpha expression in melanoma cells: Correlation to resistance against cytotoxic attack. Melanoma Res., 10(4):331-343. [doi:10.1097/ 00008390-200008000-00004]
3. Bjorkhem-Bergman, L., Jonsson, K., Eriksson, L.C., Olsson, J.M., Lehmann, S., Paul, C., Bjornstedt, M., 2002. Drug-resistant human lung cancer cells are more sensitive to selenium cytotoxicity. Effects on thioredoxin reductase and glutathione reductase. Biochem. Pharmacol., 63(10):1875-1884. [doi:10.1016/S0006-2952(02)00981-4]
4. Chae, H.Z., Chung, S.J., Rhee, S.G., 1994. Thioredoxin-dependent peroxide reductase from yeast. J. Biol. Chem., 269(44):27670-27678.
5. Coligan, J.E., Kruisbeek, A.M., Margulies, D.H., Shevach, E.M., Strober, W., 1997. Current Protocols in Immunology. John Wiley & Sons, New York.
6. Hirota, K., Matsui, M., Iwata, S., Nishiyama, A., Mori, K., Yodoi, J., 1997. AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1. Proc. Natl. Acad. Sci. USA, 94(8):3633-3638. [doi:10.1073/pnas.94.8.3633]
7. Holmgren, A., 1985. Thioredoxin. Annu. Rev. Biochem., 54(1):237-271. [doi:10.1146/annurev.bi.54.070185.001321]
8. Kahlos, K., Soini, Y., Saily, M., Koistinen, P., Kakko, S., Paakko, P., Holmgren, A., Kinnula, V.L., 2001. Up-regulation of thioredoxin and thioredoxin reductase in human malignant pleural mesothelioma. Int. J. Cancer, 95(3):198-204. [doi:10.1002/ 1097-0215(20010520)95:3<198::AID-IJC1034>3.0.CO;2-F]
9. Kakolyris, S., Giatromanolaki, A., Koukourakis, M., Powis, G., Souglakos, J., Sivridis, E., Georgoulias, V., Gatter, K.C., Harris, A.L., 2001. Thioredoxin expression is associated with lymph node status and prognosis in early operable non-small cell lung cancer. Clin. Cancer Res., 7(10):3087-3091.
10. Lan, L., Zhao, F., Wang, Y., Zeng, H., 2007. The mechanism of apoptosis induced by a novel thioredoxin reductase inhibitor in A549 cells: possible involvement of nuclear factor-kappaB-dependent pathway. Eur. J. Pharmacol., 555(2-3):83-92. [doi:10.1016/j.ejphar.2006.10.037]
11. Laurent, T.C., Moore, E.C., Reichard, P., 1964. Enzymatic synthesis of deoxyribonucleotides VI. Isolation and characterization of thioredoxin, the hydrogen donor from Escherichia coli B. J. Biol. Chem., 239(12):3436-3444.
12. Makino, Y., Yoshikawa, N., Okamoto, K., Hirota, K., Yodoi, J., Makino, I., Tanaka, H., 1999. Direction association with thioredoxin allows redox regulation of glucocorticoid receptor function. J. Biol. Chem., 274(5):3182-3188. [doi:10.1074/jbc.274.5.3182]
13. Pallis, M., Bradshaw, T.D., Westwell, A.D., Grundy, M., Stevens, M.F., Russell, N., 2003. Induction of apoptosis without redox catastrophe by thioredoxin-inhibitory compounds. Biochem. Pharmacol., 66(9):1695-1705. [doi:10.1016/S0006-2952(03)00471-4]
14. Powis, G., Kirkpatrick, D.L., Angulo, M., Baker, A., 1998. Thioredoxin redox control of cell growth and death and the effects of inhibitors. Chem. Biol. Interact., 111-112(1):23-34. [doi:10.1016/ S0009-2797(97)00148-8]
15. Powis, G., Mustacich, D., Coon, A., 2000. The role of the redox protein thioredoxin in cell growth and cancer. Free Radic. Biol. Med., 29(3-4):312-322. [doi:10.1016/S0891-5849(00)00313-0]
16. Raffel, J., Bhattacharyya, A.K., Gallegos, A., Cui, H., Einspahr, J.G., Alberts, D.S., Powis, G., 2003. Increased expression of thioredoxin-1 in human colorectal cancer is associated with decreased patient survival. J. Lab. Clin. Med., 142(1):46-51. [doi:10.1016/S0022-2143(03)00068-4]
17. Saitoh, M., Nishitoh, H., Fujii, M., Takeda, K., Tobiume, K., Sawada, Y., Kawabata, M., Miyazono, K., Ichijo, H., 1998. Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1. EMBO J., 17(9):2596-2606. [doi:10.1093/emboj/17.9.2596]
18. Sasada, T., Nakamura, H., Ueda, S., Sato, N., Kitaoka, Y., Gon, Y., Takabayashi, A., Apyrou, G., Holmgren, A., Yodoi, J., 1999. Possible involvement of thioredoxin reductase as well as thioredoxin in cellular sensitivity to cis-diamminedichloroplatinum(II). Free Radic. Biol. Med., 27(5-6):504-514. [doi:10.1016/S0891-5849(99)00101-X]
19. Shao, L., Diccianni, M.B., Tanaka, T., Gribi, R., Yu, A.L., Pullen, J.D., Camitta, B.M., Yu, J., 2001. Thioredoxin expression in primary T-cell acute lymphoblastic leukemia and its therapeutic implication. Cancer Res., 61(10):7333-7338.
20. Shi, C., Yu, L., Yang, F., Yan, J., Zeng, H., 2003. A novel organoselenium compound induces cell cycle arrest and apoptosis in prostate cancer cell lines. Biochem. Biophys. Res. Commun., 309(3):578-583. [doi:10.1016/j.bbrc.2003.08.032]
21. Söderberg, A., Sahaf, B., Rosn, A., 2000. Thioredoxin reductase, a redox-active selenoprotein, is secreted by normal and neoplastic cells: presence in human plasma. Cancer Res., 60(4):2281-2289.
22. Soini, Y., Kahlos, K., Näpänkangas, U., Kaarteenaho-Wiik, R., Säily, M., Koistinen, P., Pääakkö, P., Holmgren, A., Kinnula, V.L., 2001. Widespread expression of thioredoxin and thioredoxin reductase in non-small cell lung carcinoma. Clin. Cancer Res., 7(6):1750-1757.
23. Teshigawara, K., Maeda, M., Nishino, K., Nikaido, T., Uchiyama, T., Tsudo, M., Wano, Y., Yodoi, J., 1985. Adult T leukemia cells produce a lymphokine that augments interleukin 2 receptor expression. J. Mol. Cell. Immunol., 2(1):17-26.
24. Wang, J., Kobayashi, M., Sakurada, K., Imamura, M., Moriuchi, T., Hosokawa, M., 1997. Possible roles of an adult T-cell leukemia (ATL)-derived factor/thioredoxin in the drug resistance of ATL to Adriamycin. Blood, 89(7):2480-2487.
25. Yokomizo, A., Ono, M., Nanri, H., Makino, Y., Ohga, T., Wada, M., Okamoto, Y., Yodoi, J., Kuwano, M., Kohno, K., 1995. Cellular levels of thioredoxin associated with drug sensitivity to cisplatin, mitomycin C, doxorubicin, and etoposide. Cancer Res., 55(19):4293-4296.
26. Zhao, F., Yan, J., Deng, S., Lan, L., He, F., Kuang, B., Zeng, H., 2006. A thioredoxin reductase inhibitor induces growth inhibition and apoptosis in five cultured human carcinoma cell lines. Cancer Lett., 236(1):46-53. [doi:10.1016/j.canlet.2005.05.010]