Coagulopathy after cardiac surgery may be influenced by a functional plasminogen activator inhibitor polymorphism

Anesthesia and Analgesia

Volumn 104, Issue 6, 2007, Pages 1343-1347

  Duggan, Edel ^a   O'Dwyer, Michael J ^a   Caraher, Emma ^a,b   Diviney, Dara ^a   McGovern, Eilis ^c   Kelleher, Dermot ^a,b   McManus, Ross ^a,b   Ryan, Thomas ^a,c  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b Dublin Molecular Medicine Centre   (Ireland)

^c ST JAMES S HOSPITAL   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; MESSENGER RNA; PLASMINOGEN ACTIVATOR INHIBITOR 1;

ADULT; ALLELE; ARTICLE; BLOOD CLOTTING DISORDER; BLOOD SAMPLING; CARDIOPULMONARY BYPASS; CONTROLLED STUDY; DATA ANALYSIS; DNA DETERMINATION; ELECTIVE SURGERY; FEMALE; GENE EXPRESSION; GENETIC POLYMORPHISM; GENOTYPE; HEART SURGERY; HOMOZYGOSITY; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; MONONUCLEAR CELL; MORBIDITY; OPERATION DURATION; PERIOPERATIVE PERIOD; PRIORITY JOURNAL; TRANSFUSION;

BLOOD COAGULATION DISORDERS; CARDIOVASCULAR SURGICAL PROCEDURES; FEMALE; GENE EXPRESSION REGULATION; GENETIC MARKERS; HUMANS; MALE; MIDDLE AGED; PLASMINOGEN ACTIVATOR INHIBITOR 1; POLYMORPHISM, GENETIC; POSTOPERATIVE COMPLICATIONS;

EID: 34249005539     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/01.ane.0000261267.28891.00     Document Type: Article

References (7)

1. Hermans PW, Hibberd ML, Booy R, et al. 4G/5G promoter polymorphism in the plasminogen activator inhibitor 1 gene and outcome of meningococcal disease. Lancet 1999;354:556-60.
2. Sartori MT, Danesin C, Saggiorato G, et al. The PAI-1 gene 4G/5G polymorphism and deep vein thrombosis in patients with inherited thrombophilia. Clin Appl Thromb Hemost 2003;9:299-307.
3. Menges T, Hermans PW, Little SG, et al. Plasminogen activator inhibitor-1 4G/5G promoter polymorphism and prognosis of severely injured patients. Lancet 2001;357:1096-7.
4. Schleef RR, Higgins DL, Pillemer E, Levitt LJ. Bleeding diathesis due to decreased functional activity of type 1 plasminogen activator inhibitor. J Clin Invest 1989;83:1747-52.
5. Lee MH, Vosburgh E, Anderson K, McDonagh J. Deficiency of plasma plasminogen activator inhibitor 1 results in hyperfibrinolytic bleeding. Blood 1993;81:2357-62.
6. Fay WP, Parker AC, Condrey LR, Shapiro AD. Human plasminogen activator inhibitor-1 (PAI-1) deficiency: characterization of a large kindred with a null mutation in the PAI-1 gene. Blood 1997;90:204-8.
7. Eriksson P, Kallin B, van't Hooft FM, et al. Allele-specific increase in basal transcription of the plasminogen-activator inhibitor 1 gene is associated with myocardial infarction. Proc Natl Acad Sci USA 1995;92:1851-5.