T-oligos as differential modulators of human scalp hair growth and pigmentation: A new "time lapse system" for studying human skin and hair follicle biology in vitro?

Archives of Dermatological Research

Volumn 300, Issue 4, 2008, Pages 155-159

  Hadshiew, Ina ^a   Barre, Kirsten ^a   Bódó, Enikö ^b   Funk, Wolfgang ^c   Paus, Ralf ^b  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^c Klinik Dr Kozlowski   (Germany)

Author keywords

Hair follicle pigmentation; Hair matrix proliferation; Hair shaft elongation; Oligonucleotides

Indexed keywords

OLIGONUCLEOTIDE; T OLIGOS; UNCLASSIFIED DRUG;

ADULT; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; HAIR FOLLICLE; HAIR GROWTH; HAIR ROOT; HUMAN; HUMAN CELL; IN VITRO STUDY; KERATINOCYTE; MELANOCYTE; PIGMENTATION; PRIORITY JOURNAL; SCALP HAIR; SKIN; TELOMERE;

APOPTOSIS; CELL PROLIFERATION; FEMALE; HAIR; HAIR FOLLICLE; HUMANS; KERATINOCYTES; MELANOCYTES; MIDDLE AGED; OLIGONUCLEOTIDES; ORGAN CULTURE TECHNIQUES; SCALP; SKIN PIGMENTATION; TIME FACTORS;

EID: 41049115180     PISSN: 03403696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00403-008-0833-6     Document Type: Article

References (26)

1. Hadshiew IM, Eller MS, Gasparro FP, Gilchrest BA (2001) Stimulation of melanogenesis by DNA oligonucleotides: effect of size, sequence and 5′ phosphorylation. J Dermatol Sci 25:127-138
2. Hadshiew IM, Eller MS, Gilchrest BA (2000) Stimulation of melanogenesis by oligonucleotides in vitro and in vivo. Arch Dermatol Res 292:117
3. Eller MS, Puri N, Hadshiew IM, Venna SS, Gilchrest BA (2002) Induction of apoptosis by telomere 3′ overhang-specific DNA. Exp Cell Res 276:185-193
4. Marwaha V, Chen YH, Helms E, Arad S, Inoue H, Bord E, Kishore R, Sarkissian RD, Gilchrest BA, Goukassian DA (2005) T-oligo treatment decreases constitutive and UVB-induced COX-2 levels through p53- and NFkappaB-dependent repression of the COX-2 promoter. J Biol Chem 16:32379-32388
5. Eller MS, Maeda T, Magnoni C, Atwal D, Gilchrest BA (1997) Enhancement of DNA repair in human skin cells by thymidine dinucleotides: evidence for a p53-mediated mammalian SOS response. Proc Natl Acad Sci USA 94:12627-12632
6. Hadshiew IM, Khlgatian MK, Giese H, Eller MS, Vijg J, Gilchrest BA (1999) Reduktion der UV-induzierten Mutationstrate durch Behandlung mit dem Thymidin Dinucleotid (pTpT) (Reduction of UV-induced mutation frequency by treatment with thymidine dinucleotide, pTpT). In: Meigel (ed). Dermatologie an der Schwelle zum neuen Jahrtausend- Aktueller Stand von Klinik und Forschung. Springer, Berlin, pp 652-654
7. Hadshiew I, Barre K, Bódó E, Paus R (2005) T-oligos stimulate human scalp hair follicle pigmentation, but inhibit human hair matrix keratinocyte proliferation and hair shaft elongation. J Invest Dermatol Suppl abstr 789
8. Ito T, Ito N, Saathoff M, Bettermann A, Takigawa M, Paus R (2005) Interferon-γ is a potent inducer of catagen-like changes in cultured human anagen hair follicle. Br J Dermatol 152:623-631
9. Paus R, Cotsarelis G (1999) The biology of hair follicles. N Engl J Med 341(7):491-497
10. Peters EM, Stieglitz MG, Liezman C, Overall RW, Nakamura M, Hagen E, Klapp BF, Arck P, Paus R (2006) p75 neurotrophin receptor-mediated signaling promotes human hair follicle regression (Catagen). Am J Pathol 168(1):221-234
11. Philpott M (1999) In vitro maintenance of isolated hair follicles: current status and future development. Exp Dermatol 8:317-319
12. Botchkareva NV, Khlgatian M, Longley BJ, Botchkarev VA, Gilchrest BA (2001) Scf/c-Kit signaling is required for cyclic regeneration of the hair pigmentation unit. FASEB J 15:645-658
13. Slominski A, Wortsman J, Plonka PM et al (2005) Hair follicle pigmentation. J Invest Dermatol 124:13-21
14. Slominski A, Paus R, Plonka P et al (1994) Melanogenesis during the anagen-catagen-telogen transformation of the murine hair cycle. J Invest Dermatol 102:862-869
15. Slominski A, Paus R (1993) Melanogenesis is coupled to murine anagen: toward new concepts for the role of melanocytes and the regulation of melanogenesis in hair growth. J Invest Dermatol 101(1):90-97
16. Tobin DJ, Slominski A, Botchkarev V, Paus R (1999) The fate of hair follicle melanocytes during the hair growth cycle. J Invest Dermatol Symp Proc 4:323-332
17. Nishimura EK, Granter SR, Fisher DE (2005) Mechanisms of hair graying: incomplete melanocyte stem cell maintenance in the niche. Science 307(5710):720-724
18. Tobin DJ, Paus R (2001) Graying: gerontobiology of the hair follicle pigmentary unit. Exp Gerontol 36:29-54
19. Bodó E, Tobin DJ, Kamenisch Y, Bíró T, Berneburg M, Funk W, Paus R (2007) Dissecting the impact of chemotherapy on the human hair follicle: a pragmatic in vitro assay for studying the pathogenesis and potential management of hair follicle dystrophy. Am J Pathol 171:1153-1167
20. Nylander K, Bourdon JC, Bray SE, Gibbs NK, Kay R, Hart I, Hall PA (2000) Transcriptional activation of tyrosinase and TRP-1 by p53 links UV irradiation to the protective tanning response. J Pathol 190(1):39-46
21. Atoyan RY, Sharov AA, Eller MS, Sargsyan A, Botchkarev VA, Gilchrest BA (2007) Oligonucleotide treatment increases eumelanogenesis, hair pigmentation and melanocortin-1 receptor expression in the hair follicle. Exp Dermatol 16(8):671-677
22. Gilchrest BA, Eller MS (1999) DNA photodamage stimulates melanogenesis and other photoprotective responses. J Investig Dermatol Symp Proc 4:35-40
23. Eller MS, Ostrom K, Gilchrest BA (1996) DNA damage enhances melanogenesis. Proc Natl Acad Sci USA 93:1087-1092
24. Eller MS, Yaar M, Gilchrest BA (1994) DNA damage and melanogenesis. Nature 372:413-414
25. Gilchrest BA, Park HY, Eller MS, Yaar M (1996) Mechanisms of ultraviolet light-induced pigmentation. Photochem Photobiol 63:1-10
26. Khlgatian MK, Hadshiew IM, Asawanonda P, Yaar M, Eller MS, Fujita M, Norris DA, Gilchrest BA (2002) Tyrosinase gene expression is regulated by p53. J Invest Dermatol 118(1):126-132