Dihydrodiol dehydrogenases regulate the generation of reactive oxygen species and the development of cisplatin resistance in human ovarian carcinoma cells

Cancer Chemotherapy and Pharmacology

Volumn 61, Issue 6, 2008, Pages 979-987

  Chen, Jianli ^a   Adikari, Mahesha ^a   Pallai, Rajash ^a   Parekh, Hemant K ^a   Simpkins, Henry ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cisplatin resistance; Dihydrodiol dehydrogenases; Human ovarian carcinoma cells; Reactive oxygen species

Indexed keywords

CISPLATIN; DIHYDRODIOL DEHYDROGENASE; DIHYDRODIOL DEHYDROGENASE 1; DIHYDRODIOL DEHYDROGENASE 2; HYDROGEN PEROXIDE; ISOPROTEIN; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; COLONY FORMATION; CONTROLLED STUDY; DETOXIFICATION; ENZYME REGULATION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; OVARY CARCINOMA; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ALCOHOL OXIDOREDUCTASES; ANTINEOPLASTIC AGENTS; BLOTTING, WESTERN; CELL LINE, TUMOR; CISPLATIN; CLONE CELLS; DRUG RESISTANCE, NEOPLASM; ENZYME INDUCTION; ESTERASES; FEMALE; HEME OXYGENASE (DECYCLIZING); HUMANS; HYDROGEN PEROXIDE; ISOENZYMES; OVARIAN NEOPLASMS; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; TERT-BUTYLHYDROPEROXIDE;

EID: 41049113672     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-007-0554-0     Document Type: Article

References (33)

1. Andrew PA, Velury S, Mann SC, Howell SB (1988) cis- diamminedichloroplatinum (II) accumulation in sensitive and resistant human ovarian carcinoma cells. Cancer Res 48:68-73
2. Andrews PA, Albright KD (1992) Mitochondrial defects in cis-diamminedichloroplatinum (II)-resistant human ovarian carcinoma cells. Cancer Res 52:1895-1901
3. Ax W, Soldan M, Koch L, Maser E (2000) Development of duanorubicin resistance in tumor cells by induction of carbonyl reductase. Biochem Pharmacol 59:293-300
4. Biroccio A, Benassi B, Amodei S, Gabellini C, Del Bufalo D, Zupi G (2001) c-Myc down-regulation increases susceptibility to cisplatin through reactive oxygen species-mediated apoptosis in M14 human melanoma cells. Mol Pharmacol 60:174-182
5. Burczynski ME, Lin HK, Penning TM (1999) Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase. Cancer Res 59:607-614
6. Christen RJ, Jekunen AP, Jones JA, Thiebaut F, Shalinsky DR, Howell SB (1993) In vitro modulation of cisplatin accumulation in human ovarian carcinoma cells by pharmacological alteration of microtubules. J Clin Invest 92:431-440
7. Chung YM, Yoo YD, Park JK, Kim YT, Kim HJ (2001) Increased expression of peroxiredoxin II confers resistance to cisplatin. Anticancer Res 21:1129-1133
8. Ciaccio PJ, Stuart JE, Tew KD (1993) Overproduction of a 37.5-kDa cytosolic protein structurally similar to prostaglandin F synthase in ethacrynic acid-resistant human colon cells. Mol Pharmacol 43:845-853
9. Deng HB, Parekh HK, Chow KC, Simpkins H (2002) Increased expression of dihydrodiol dehydrogenase induces resistance to cisplatin in human ovarian carcinoma cells. J Biol Chem 277:15035-15043
10. Deng HB, Adikari M, Parekh HK, Simpkins H (2004) Ubiquitous induction of resistance to platinum drugs in human ovarian, cervical, germ-cell and lung carcinoma tumor cells overexpressing isoforms 1 and 2 of dihydrodiol dehydrogenase. Cancer Chemother Pharmacol 54:301-307
11. Gebauer G, Mirakhur B, Nguyen Q, Shore SK, Simpkins H, Dhanasekaran N (2000) Cisplatin-resistance involves the defective processing of MEKK1 in human ovarian adenocarcinoma 2008/C13 cells. Int J Oncol 16:321-325
12. Gius D, Spitz DR (2006) Redox signaling in cancer biology. Antioxid Redox Signal 8:1249-1252
13. Hamers T, Molin KR, Koeman JH, Murk AJ (2000) A small-volume bioassay for quantification of the esterase inhibiting potency of mixtures of organophosphate and carbamate insecticides in rainwater:development and optimization. Toxicol Sci 58:60-67
14. Isonishi S, Jekunen AP, Hom DH, Eastman A, Edelstein PS, Thiebaut FB, Christen RD, Howell SB (1992) Modulation of cisplatin sensitivity and growth rate of an ovarian carcinoma cell line by bombesin and tumor necrosis factor α. J Clin Invest 90:1436-1442
15. Jeong WS, Jun M, Kong AN (2006) Nrf2: a potential molecular target for cancer chemoprevention by natural compounds. Antioxid Redox Signal 8:99-106
16. Loehrer PJ, Einhorn LH (1984) Drugs five years later. Cisplatin Ann Intern Med 100:704-713
17. Mamenta EL, Poma EE, Kaufmann WK, Delmastro DA, Grady HL, Chaney SG (1994) Enhanced replicative bypass of platinum-DNA adducts in cisplatin-resistant human ovarian carcinoma cell lines. Cancer Res 54:3500-3505
18. Mann SC, Andrews PA, Howell SB (1991) Modulation of cis- diamminedichloroplatinum (II) accumulation and sensitivity by forkolin and 3 isobutyl-1 methylxanthine in sensitive and resistant human ovarian carcinoma cells. Int J Cancer 48:866-872
19. Mirakhur B, Parekh HK, Simpkins H (1996) Expression of the cisplatin resistance phenotype in a human ovarian carcinoma cell line segregates with chromosome 11 and 16. Cancer Res 56:2256-2262
20. Moorehead RA, Singh G (2000) Influence of the proto-oncogene c-fos on cisplatin sensitivity. Biochem Pharmacol 59:337-345
21. Mattiasson G (2004) Analysis of mitochondrial generation and release of reactive oxygen species. Cytometry A 62:89-96
22. Ogasawara H, Nishio K, Kanzawa F, Lee YS, Funayama Y, Ohira T, Kuraishi Y, Isogai Y, Saijo N (1995) Intracellular carboxyl esterase activity is a determinant of cellular sensitivity to the antineoplastic agent KW-2189 in cell lines resistant to cisplatin and CPT-11. Jpn J Cancer Res 86:124-129
23. Ozols RF, Williams SD (1989) Testicular cancer. Curr Prob Cancer 13:287-335
24. Parekh HK, Simpkins H (1995) The differential expression of cytokeratin 18 in cisplatin-sensitive and -resistant human ovarian adenocarcinoma cells and its association with drug sensitivity. Cancer Res 55:5203-5206
25. Penning TM, Burczynski ME, Jez JM, Hung CF, Lin HK, Ma H, Moore M, Palackal N, Ratnam K (2000) Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones. Biochem J 351:67-77
26. Smithgall TE, Harvey RG, Penning TM (1986) Regio- and stereospecificity of homogeneous 3 alpha-hydroxysteroid-dihydrodiol dehydrogenase for trans-dihydrodiol metabolites of polycyclic aromatic hydrocarbons. J Biol Chem 261:6184-6191
27. Smithgall TE, Harvey RG, Penning TM (1988) Oxidation of the trans-3,4-dihydrodiol metabolites of the potent carcinogen 7,12-dimethylbenz(a) anthracene and other benz(a)anthracene derivatives by 3 alpha-hydroxysteroid- dihydrodiol dehydrogenase: effects of methyl substitution on velocity and stereochemical course of trans-dihydrodiol oxidation. Cancer Res 48:1227-1232
28. Smithgall TE, Harvey RG, Penning TM (1988) Spectroscopic identification of ortho-quinones as the products of polycyclic aromatic trans-dihydrodiol oxidation catalyzed by dihydrodiol dehydrogenase. A potential route of proximate carcinogen metabolism. J Biol Chem 263:1814-1820
29. -) by murine macrophages in vitro after cis-platin treatment. Int J Immunopharmacol 8:709-714
30. Spitz DR, Phillips JW, Adams DT, Sherman CM, Deen DF, Li GC (1993) Cellular resistance to oxidative stress is accompanied by resistance to cisplatin: the significance of increased catalase activity and total glutathione in hydrogen peroxide-resistant fibroblasts. J Cell Physiol 156:72-79
31. Sung YJ, Cheng CL, Chen CS, Huang HB, Huang FL, Wu PC, Shiao MS, Tsay HJ (2003) Distinct mechanisms account for beta-amyloid toxicity in PC12 and differentiated PC12 neuronal cells. J Biomed Sci 10:379-388
32. Timmer-Bosscha H, Mulder NH, de Vries EGE (1992) Modulation of cis-diamminedichloroplatinum(II) resistance: a review. Br J Cancer 66:227-238
33. Zvereva E, Serebrov V, Glupov V, Dubovskiy I (2003) Activity and heavy metal resistance of non-specific esterases in leaf beetle Chrysomela lapponica from polluted and unpolluted habitats. Comp Biochem Physiol C Toxicol Pharmacol 135:383-391