Augmented antioxidant status in Tamoxifen treated postmenopausal women with breast cancer on co-administration with Coenzyme Q10, Niacin and Riboflavin

Cancer Chemotherapy and Pharmacology

Volumn 61, Issue 6, 2008, Pages 933-941

  Yuvaraj, Srinivasan ^a   Premkumar, Vummidi Giridhar ^a   Vijayasarathy, Kothandaraman ^b   Gangadaran, Sitthu Govindaswamy Dinakaran ^b   Sachdanandam, Panchanatham ^a  

^a UNIVERSITY OF MADRAS   (India)

^b Kilpauk Medical College   (India)

Author keywords

Breast cancer; Combinatorial therapy; CoQ 10; Niacin; Oxidative stress; Riboflavin; Tamoxifen

Indexed keywords

HYDROGEN PEROXIDE; HYDROXYL RADICAL; LIPID PEROXIDE; NICOTINIC ACID; REACTIVE OXYGEN METABOLITE; RIBOFLAVIN; SUPEROXIDE; TAMOXIFEN; UBIDECARENONE;

ADULT; AGED; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD SAMPLING; BREAST CANCER; CANCER ADJUVANT THERAPY; CANCER PATIENT; CARCINOGENESIS; CONTROLLED STUDY; ENDOMETRIUM; FEMALE; HUMAN; HYPERTRIGLYCERIDEMIA; LIPID BLOOD LEVEL; LIPID PEROXIDATION; LIVER; MAJOR CLINICAL STUDY; OXIDATIVE STRESS; PATHOGENESIS; POSTMENOPAUSE; PRIORITY JOURNAL; TUMOR PROMOTION; VITAMIN SUPPLEMENTATION;

ADULT; AGED; ANTINEOPLASTIC AGENTS, HORMONAL; ANTIOXIDANTS; BREAST NEOPLASMS; ENZYMES; FEMALE; HUMANS; LIPID PEROXIDATION; LIPIDS; MIDDLE AGED; NIACIN; OXIDATIVE STRESS; RIBOFLAVIN; TAMOXIFEN; THIOBARBITURIC ACID REACTIVE SUBSTANCES; UBIQUINONE;

EID: 41049106955     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-007-0547-z     Document Type: Article

References (60)

1. American Cancer Society (2007) Breast cancer facts and figures 2005-2006. http://www.cancer.org/docroot/STT/stt/0/2006.asp. cited 13 Mar 2007
2. Yancik R, Ries LA (2000) Aging and cancer in America. Demographic and epidemiologic perspectives. Hematol Oncol Clin North Am 14:17-23
3. Parkin DM (1998) The global burden of cancer. Semin Cancer Biol 8:219-235
4. Gajalakshmi CK, Shanta V, Swaminathan R, Sankaranarayanan R, Black RJ (1997) A population-based survival study on female breast cancer in Madras, India. Br J Cancer 75:771-775
5. Sies H (1997) Oxidative stress: oxidants and antioxidants. Exp Physiol 82:291-295
6. Ray G, Batra S, Shukla NK, Deo S, Raina V, Ashok S, Husain SA (2000) Lipid peroxidation, free radical production and antioxidant status in breast cancer. Breast Cancer Res Treat 59:163-170
7. Vaca CE, Wilhelm J, Harms-Ringdahl M (1988) Interaction of lipid peroxidation products with DNA. A review. Mutat Res 195:137-149
8. Polat MF, Taysi S, Gul M, Cikman O, Yilmaz I, Bakan E, Erdogan F (2002) Oxidant/antioxidant status in blood of patients with malignant breast tumour and benign breast disease. Cell Biochem Funct 20:327-331
9. Bakan N, Taysi S, Yilmaz O, Bakan E, Kuskay S, Uzun N, Gundogdu M (2003) Glutathione peroxidase, glutathione reductase, Cu-Zn superoxide dismutase activities, glutathione, nitric oxide, and malondialdehyde concentrations in serum of patients with chronic lymphocytic leukemia. Clin Chim Acta 338:143-149
10. Howell A, Osborne CK, Morris C, Wakeling AE (2000) ICI 182,780 (Faslodex): development of a novel, "pure" antiestrogen. Cancer 89:817-825
11. Adlard JW, Campbell J, Bishop JM, Dodwell DJ (2002) Morbidity of tamoxifen-perceptions of patients and healthcare professionals. Breast 11:335-339
12. Elefsiniotis IS, Pantazis KD, Ilias A, Pallis L, Mariolis A, Glynou I, Kada H, Moulakakis A (2004) Tamoxifen induced hepatotoxicity in breast cancer patients with pre-existing liver steatosis: the role of glucose intolerance. Eur J Gastroenterol Hepatol 16:593-598
13. Yuvaraj S, Premkumar VG, Vijayasarathy K, Gangadaran SG, Sachdanandam P (2007) Ameliorating effect of coenzyme Q(10), riboflavin and niacin in tamoxifen-treated postmenopausal breast cancer patients with special reference to lipids and lipoproteins. Clin Biochem 40:623-628
14. Lox C, Ronaghan C, Cobos E (1998) Blood chemistry profiles in menopausal women administered tamoxifen for breast cancer. Gen Pharmacol 30:121-124
15. El-Beshbishy HA (2005) The effect of dimethyl dimethoxy biphenyl dicarboxylate (DDB) against tamoxifen-induced liver injury in rats: DDB use is curative or protective. J Biochem Mol Biol 38:300-306
16. Da Costa GG, McDaniel-Hamilton LP, Heflich RH, Marques MM, Beland FA (2001) DNA adduct formation and mutant induction in Sprague-Dawley rats treated with tamoxifen and its derivatives. Carcinogenesis 22:1307-1315
17. Tabassum H, Rehman H, Banerjee BD, Raisuddin S, Parvez S (2001) Attenuation of tamoxifen-induced hepatotoxicity by taurine in mice. Clin Chim Acta 370:129-136
18. Nohl H, Gille L, Kozlov AV (1999) Critical aspects of the antioxidant function of coenzyme Q in biomembranes. Biofactors 9:155-161
19. Yalcin A, Kilinc E, Sagcan A, Kultursay H (2004) Coenzyme Q10 concentrations in coronary artery disease. Clin Biochem 37:706-709
20. Premkumar VG, Yuvaraj S, Vijayasarathy K, Gangadaran SG, Sachdanandam P (2007) Effect of coenzyme Q10, riboflavin and niacin on serum CEA and CA 15-3 levels in breast cancer patients undergoing tamoxifen therapy. Biol Pharm Bull 30:367-370
21. Perumal SS, Shanthi P, Sachdanandam P (2005) Augmented efficacy of tamoxifen in rat breast tumorigenesis when gavaged along with riboflavin, niacin, and CoQ10: effects on lipid peroxidation and antioxidants in mitochondria. Chem Biol Interact 152:49-58
22. Imada Y, Iida H, Ono S, Murahashi S (2003) Flavin catalyzed oxidations of sulfides and amines with molecular oxygen. J Am Chem Soc 125:2868-2869
23. Ganji SH, Kamanna VS, Kashyap ML (2003) Niacin and cholesterol: role in cardiovascular disease (review). J Nutr Biochem 14:298-305
24. Yagi K (1976) A simple fluorometric assay for lipoperoxide in blood plasma. Biochem Med 15:212-216
25. Rouser G, Fkeischer S, Yamamoto A (1970) Two dimensional thin layer chromatographic separation of polar lipids and determination of phospholipids by phosphorus analysis of spots. Lipids 5:494-496
26. Marklund S, Marklund G (1974) Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 47:469-474
27. Sinha AK (1972) Colorimetric assay of catalase. Anal Biochem 47:389-394
28. Habig WH, Jakoby WB (1981) Assays for differentiation of glutathione S-transferases. Methods Enzymol 77:398-405
29. Beutler E, Duron O, Kelly BM (1963) Improved method for the determination of blood glutathione. J Lab Clin Med 61:882-888
30. Omaye ST, Turnbull JD, Sauberlich HE (1979) Selected methods for the determination of ascorbic acid in animal cells, tissues, and fluids. Methods Enzymol 62:3-11
31. Hansen LG, Warwick WJ (1969) A fluorometric micromethod for serum vitamins A and E. Tech Bull Regist Med Technol 39:70-73
32. Baker H, Frank O, De Angelis B, Feingold S (1989) Plasma tocopherol in man at various times after ingesting free or acetylated tocopherol. Nutr Rep Int 21:531-536
33. Darbkin DL, Austin JM (1932) Spectrophotometric studies, spectrophotometric constants for common haemoglobin derivatives in human, dog and rabbit blood. J Biol Chem 98:719-733
34. Ray G, Husain SA (2001) Role of lipids, lipoproteins and vitamins in women with breast cancer. Clin Biochem 34:71-76
35. Summerfield FW, Tappel AL (1983) Determination by fluorescence quenching of the environment of DNA crosslinks made by malondialdehyde. Biochim Biophys Acta 740:185-189
36. Szepsenwol J (1966) Carcinogenic effect of cholesterol in mice. Proc Soc Exp Biol Med 21:168-171
37. Babu JR, Sundravel S, Arumugam G, Renuka R, Deepa N, Sachdanandam P (2000) Salubrious effect of vitamin C and vitamin E on tamoxifen-treated women in breast cancer with reference to plasma lipid and lipoprotein levels. Cancer Lett 151:1-5
38. Takatani O, Okumoto T, Kosano H (1991) Genesis of breast cancer in Japanese: a possible relationship between sex hormone binding globulin (SHBG) and serum lipid components. Breast Cancer Res Treat 18(Suppl 1):S27-S29
39. Premkumar VG, Yuvaraj S, Vijayasarathy K, Gangadaran SG, Sachdanandam P (2007) Serum cytokine levels of interleukin-1beta, -6, -8, tumour necrosis factor-alpha and vascular endothelial growth factor in breast cancer patients treated with Tamoxifen and supplemented with Co-enzyme Q(10), Riboflavin and Niacin. Basic Clin Pharmacol Toxicol 100:387-391
40. Jablonska E, Kiluk M, Markiewicz W, Piotrowski L, Grabowska Z, Jablonski J (2001) TNF-α, IL-6 and their soluble receptor serum levels and secretion by neutrophils in cancer patients. Arch Immunol Ther Exp 49:63-69
41. Zhao SP, Wu J (2004) Fenofibrate reduces tumor necrosis factor-alpha serum concentration and adipocyte secretion of hypercholesterolemic rabbits. Clin Chim Acta 347:145-150
42. James AM, Smith RA, Murphy MP (2004) Antioxidant and prooxidant properties of mitochondrial Coenzyme Q. Arch Biochem Biophys 423:47-56
43. Kagan V, Serbinova E, Packer L (1990) Antioxidant effects of ubiquinones in microsomes and mitochondria are mediated by tocopherol recycling. Biochem Biophys Res Commun 169:851-857
44. Powers HJ (1999) Current knowledge concerning optimum nutritional status of riboflavin, niacin and pyridoxine. Proc Nutr Soc 58:435-440
45. Jin FY, Kamanna VS, Kashyap ML (1999) Niacin accelerates intracellular ApoB degradation by inhibiting triacylglycerol synthesis in human hepatoblastoma (HepG2) cells. Arterioscler Thromb Vasc Biol 19:1051-1059
46. Ferlini C, Scambia G, Marone M, Distefano M, Gaggini C, Ferrandina G, Fattorossi A, Isola G, Benedetti Panici P, Mancuso S (1999) Tamoxifen induces oxidative stress and apoptosis in oestrogen receptor-negative human cancer cell lines. Br J Cancer 79:257-263
47. Nazarewicz RR, Zenebe WJ, Parihar A, Larson SK, Alidema E, Choi J, Ghafourifar P (2007) Tamoxifen induces oxidative stress and mitochondrial apoptosis via stimulating mitochondrial nitric oxide synthase. Cancer Res 67:1282-1290
48. Yeh CC, Hou MF, Tsai SM, Lin SK, Hsiao JK, Huang JC, Wang LH, Wu SH, Hou LA, Ma H, Tsai LY (2005) Superoxide anion radical, lipid peroxides and antioxidant status in the blood of patients with breast cancer. Clin Chim Acta 361:104-111
49. Buzby GP, Mullen JL, Stein TP, Miller EE, Hobbs CL, Rosato EF (1980) Host-tumor interaction and nutrient supply. Cancer 45:2940-2948
50. Simeone AM, Ekmekcioglu S, Broemeling LD, Grimm EA, Tari AM (2002) A novel mechanism by which N-(4-hydroxyphenyl)retinamide inhibits breast cancer cell growth: the production of nitric oxide. Mol Cancer Ther 1:1009-1017
51. Michiels C, Raes M, Toussaint O, Remacle J (1994) Importance of Se-glutathione peroxidase, catalase, and Cu/Zn-SOD for cell survival against oxidative stress. Free Radic Biol Med 17:235-248
52. Yan Q, Briehl M, Crowley CL, Payne CM, Bernstein H, Bernstein C (1999) The NAD+ precursors, nicotinic acid and nicotinamide upregulate glyceraldehyde-3-phosphate dehydrogenase and glucose-6-phosphate dehydrogenase mRNA in Jurkat cells. Biochem Biophys Res Commun 255:133-136
53. Lee CK, Pugh TD, Klopp RG, Edwards J, Allison DB, Weindruch R, Prolla TA (2004) The impact of alpha-lipoic acid, coenzyme Q10 and caloric restriction on life span and gene expression patterns in mice. Free Radic Biol Med 36:1043-1057
54. Fernandez-Ayala DJ, Lopez-Lluch G, Garcia-Valdes M, Arroyo A, Navas P (2005) Specificity of coenzyme Q10 for a balanced function of respiratory chain and endogenous ubiquinone biosynthesis in human cells. Biochim Biophys Acta 1706:174-183
55. Abiaka C, Al-Awadi F, Al-Sayer H, Gulshan S, Behbehani A, Farghally M (2002) Activities of erythrocyte antioxidant enzymes in cancer patients. J Clin Lab Anal 16:167-171
56. Khanzode SS, Muddeshwar MG, Khanzode SD, Dakhale GN (2004) Antioxidant enzymes and lipid peroxidation in different stages of breast cancer. Free Radic Res 38:81-85
57. Saygili EI, Akcay T, Konukoglu D, Papilla C (2003) Glutathione and glutathione-related enzymes in colorectal cancer patients. J Toxicol Environ Health 66:411-415
58. Fang YZ, Yang S, Wu G (2002) Free radicals, antioxidants, and nutrition. Nutrition 18:872-879
59. Crane FL (2001) Biochemical functions of coenzyme Q10. J Am Coll Nutr 20:591-598
60. Kamat JP, Devasagayam TP (1996) Methylene blue plus light-induced lipid peroxidation in rat liver microsomes: inhibition by nicotinamide (vitamin B3) and other antioxidants. Chem Biol Interact 99:1-16