Rectal immunization generates protective immunity in the female genital tract against herpes simplex virus type 2 infection: Relative importance of myeloid differentiation factor 88

Antiviral Research

Volumn 78, Issue 3, 2008, Pages 202-214

  Tengvall, Sara ^a   O'Hagan, Derek ^b   Harandi, Ali M ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b Novartis Vaccines and Diagnostics   (United States)

Author keywords

Adjuvant; Genital herpes; Mucosal vaccine; MyD88; Rectal immunization; Sex hormones

Indexed keywords

CHOLERA TOXIN; CPG OLIGODEOXYNUCLEOTIDE; ESTRADIOL; GAMMA INTERFERON; GLYCOPROTEIN P 15095; HERPES VACCINE; MEDROXYPROGESTERONE ACETATE; MYELOID DIFFERENTIATION FACTOR 88; THYMIDINE KINASE; VIRUS GLYCOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CELLULAR IMMUNITY; CONTROLLED STUDY; DENDRITIC CELL; FEMALE; FEMALE GENITAL SYSTEM; GENITAL HERPES; HERPES SIMPLEX VIRUS 2; HORMONAL REGULATION; HOST RESISTANCE; IMMUNIZATION; IMMUNOHISTOCHEMISTRY; IMMUNOREGULATION; INTERFERON PRODUCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECTUM MUCOSA; VIRUS ATTENUATION; VIRUS INHIBITION; VIRUS REPLICATION; VIRUS RESISTANCE;

ADJUVANTS, IMMUNOLOGIC; ADMINISTRATION, INTRAVAGINAL; ADMINISTRATION, RECTAL; ANIMALS; ANTIBODIES, VIRAL; CELL LINE; CHOLERA TOXIN; FEMALE; HERPES GENITALIS; HERPES SIMPLEX VIRUS VACCINES; HERPESVIRUS 2, HUMAN; HUMANS; IMMUNITY, MUCOSAL; IMMUNIZATION; IMMUNOGLOBULIN G; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYELOID DIFFERENTIATION FACTOR 88; VIRAL ENVELOPE PROTEINS;

HERPES; HUMAN HERPESVIRUS 2; MUS; SIMPLEXVIRUS;

EID: 41049103060     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.antiviral.2007.12.014     Document Type: Article

References (38)

1. Brandtzaeg P. Mucosal immunity in the female genital tract. J. Reprod. Immunol. 36 (1997) 23-50
2. Bromander A., Holmgren J., and Lycke N. Cholera toxin stimulates IL-1 production and enhances antigen presentation by macrophages in vitro. J. Immunol. 146 (1991) 2908-2914
3. Bromander A.K., Kjerrulf M., Holmgren J., and Lycke N. Cholera toxin enhances alloantigen presentation by cultured intestinal epithelial cells. Scand. J. Immunol. 37 (1993) 452-458
4. Corey L., Wald A., Celum C.L., and Quinn T.C. The effects of herpes simplex virus-2 on HIV-1 acquisition and transmission: a review of two overlapping epidemics. J. Acquir. Immune Defic. Syndr. 35 (2004) 435-445
5. Crowley-Nowick P.A., Bell M.C., Brockwell R., Edwards R.P., Chen S., Partridge E.E., and Mestecky J. Rectal immunization for induction of specific antibody in the genital tract of women. J. Clin. Immunol. 17 (1997) 370-379
6. Gallichan W.S., Woolstencroft R.N., Guarasci T., McCluskie M.J., Davis H.L., and Rosenthal K.L. Intranasal immunization with CpG oligodeoxynucleotides as an adjuvant dramatically increases IgA and protection against herpes simplex virus-2 in the genital tract. J. Immunol. 166 (2001) 3451-3457
7. Gavin A.L., Hoebe K., Duong B., Ota T., Martin C., Beutler B., and Nemazee D. Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling. Science 314 (2006) 1936-1938
8. Gillgrass A.E., Ashkar A.A., Rosenthal K.L., and Kaushic C. Prolonged exposure to progesterone prevents induction of protective mucosal responses following intravaginal immunization with attenuated herpes simplex virus type 2. J. Virol. 77 (2003) 9845-9851
9. Gillgrass A.E., Fernandez S.A., Rosenthal K.L., and Kaushic C. Estradiol regulates susceptibility following primary exposure to genital herpes simplex virus type 2, while progesterone induces inflammation. J. Virol. 79 (2005) 3107-3116
10. Gillgrass A.E., Tang V.A., Towarnicki K.M., Rosenthal K.L., and Kaushic C. Protection against genital herpes infection in mice immunized under different hormonal conditions correlates with induction of vagina-associated lymphoid tissue. J. Virol. 79 (2005) 3117-3126
11. Harandi A.M. The potential of immunostimulatory CpG DNA for inducing immunity against genital herpes: opportunities and challenges. J. Clin. Virol. 30 (2004) 207-210
12. Harandi A.M., Svennerholm B., Holmgren J., and Eriksson K. Differential roles of B cells and IFN-gamma-secreting CD4(+) T cells in innate and adaptive immune control of genital herpes simplex virus type 2 infection in mice. J. Gen. Virol. 82 (2001) 845-853
13. Holmgren J., Harandi A.M., and Czerkinsky C. Mucosal adjuvants and anti-infection and anti-immunopathology vaccines based on cholera toxin, cholera toxin B subunit and CpG DNA. Expert Rev. Vaccines 2 (2003) 205-217
14. Kinghorn G.R. Epidemiology of genital herpes. J. Int. Med. Res. 22 Suppl. 1 (1994) 14A-23A
15. Krieg A.M. CpG motifs in bacterial DNA and their immune effects. Annu. Rev. Immunol. 20 (2002) 709-760
16. Krug A., Luker G.D., Barchet W., Leib D.A., Akira S., and Colonna M. Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9. Blood 103 (2004) 1433-1437
17. Kurt-Jones E.A., Chan M., Zhou S., Wang J., Reed G., Bronson R., Arnold M.M., Knipe D.M., and Finberg R.W. Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis. Proc. Natl. Acad. Sci. U.S.A. 101 (2004) 1315-1320
18. Kwant A., and Rosenthal K.L. Intravaginal immunization with viral subunit protein plus CpG oligodeoxynucleotides induces protective immunity against HSV-2. Vaccine 22 (2004) 3098-3104
19. Langman J.M., and Rowland R. The number and distribution of lymphoid follicles in the human large intestine. J. Anat. 149 (1986) 189-194
20. Lund J., Sato A., Akira S., Medzhitov R., and Iwasaki A. Toll-like receptor 9-mediated recognition of herpes simplex virus-2 by plasmacytoid dendritic cells. J. Exp. Med. 198 (2003) 513-520
21. Lycke N., Bromander A.K., Ekman L., Karlsson U., and Holmgren J. Cellular basis of immunomodulation by cholera toxin in vitro with possible association to the adjuvant function in vivo. J. Immunol. 142 (1989) 20-27
22. Mahajan A., Naylor S., Mills A.D., Low J.C., Mackellar A., Hoey D.E., Currie C.G., Gally D.L., Huntley J., and Smith D.G. Phenotypic and functional characterisation of follicle-associated epithelium of rectal lymphoid tissue. Cell Tissue Res. 321 (2005) 365-374
23. McDermott M.R., Brais L.J., and Evelegh M.J. Mucosal and systemic antiviral antibodies in mice inoculated intravaginally with herpes simplex virus type 2. J. Gen. Virol. 71 (1990) 1497-1504
24. Milligan G.N., and Bernstein D.I. Interferon-gamma enhances resolution of herpes simplex virus type 2 infection of the murine genital tract. Virology 229 (1997) 259-268
25. Mitchell E.A., Bergmeier L.A., Doyle C., Brookes R., Hussain L.A., Wang Y., and Lehner T. Homing of mononuclear cells from iliac lymph nodes to the genital and rectal mucosa in non-human primates. Eur. J. Immunol. 28 (1998) 3066-3074
26. Owen R.L., Piazza A.J., and Ermak T.H. Ultrastructural and cytoarchitectural features of lymphoreticular organs in the colon and rectum of adult BALB/c mice. Am. J. Anat. 190 (1991) 10-18
27. Parez N., Fourgeux C., Mohamed A., Dubuquoy C., Pillot M., Dehee A., Charpilienne A., Poncet D., Schwartz-Cornil I., and Garbarg-Chenon A. Rectal immunization with rotavirus virus-like particles induces systemic and mucosal humoral immune responses and protects mice against rotavirus infection. J. Virol. 80 (2006) 1752-1761
28. Parr M.B., Kepple L., McDermott M.R., Drew M.D., Bozzola J.J., and Parr E.L. A mouse model for studies of mucosal immunity to vaginal infection by herpes simplex virus type 2. Lab. Invest. 70 (1994) 369-380
29. Parr M.B., and Parr E.L. Mucosal immunity to herpes simplex virus type 2 infection in the mouse vagina is impaired by in vivo depletion of T lymphocytes. J. Virol. 72 (1998) 2677-2685
30. Parr M.B., and Parr E.L. The role of gamma interferon in immune resistance to vaginal infection by herpes simplex virus type 2 in mice. Virology 258 (1999) 282-294
31. Parr M.B., and Parr E.L. Intravaginal administration of herpes simplex virus type 2 to mice leads to infection of several neural and extraneural sites. J. Neurovirol. 9 (2003) 594-602
32. Parr M.B., and Parr E.L. Vaginal immunity in the HSV-2 mouse model. Int. Rev. Immunol. 22 (2003) 43-63
33. Sato A., Linehan M.M., and Iwasaki A. Dual recognition of herpes simplex viruses by TLR2 and TLR9 in dendritic cells. Proc. Natl. Acad. Sci. U.S.A. 103 (2006) 17343-17348
34. Shen X., Lagergård T., Yang Y., Lindblad M., Fredriksson M., and Holmgren J. Systemic and mucosal immune responses in mice after mucosal immunization with group B streptococcus type III capsular polysaccharide-cholera toxin B subunit conjugate vaccine. Infect. Immun. 68 (2000) 5749-5755
35. Stanberry L.R., Spruance S.L., Cunningham A.L., Bernstein D.I., Mindel A., Sacks S., Tyring S., Aoki F.Y., Slaoui M., Denis M., Vandepapeliere P., and Dubin G. Glycoprotein-D-adjuvant vaccine to prevent genital herpes. N. Engl. J. Med. 347 (2002) 1652-1661
36. Straus S.E., Wald A., Kost R.G., McKenzie R., Langenberg A.G., Hohman P., Lekstrom J., Cox E., Nakamura M., Sekulovich R., Izu A., Dekker C., and Corey L. Immunotherapy of recurrent genital herpes with recombinant herpes simplex virus type 2 glycoproteins D and B: results of a placebo-controlled vaccine trial. J. Infect. Dis. 176 (1997) 1129-1134
37. Tengvall S., Lundqvist A., Eisenberg R.J., Cohen G.H., and Harandi A.M. Mucosal administration of CpG oligodeoxynucleotide elicits strong CC and CXC chemokine responses in the vagina and serves as a potent Th1-tilting adjuvant for recombinant gD2 protein vaccination against genital herpes. J. Virol. 80 (2006) 5283-5291
38. Whitley R.J. Herpes simplex virus infection. Semin. Pediatr. Infect. Dis. 13 (2002) 6-11