Advanced endothelial dysfunction in diabetic patients with multiple risk factors; importance of insulin resistance

Journal of Atherosclerosis and Thrombosis

Volumn 14, Issue 6, 2007, Pages 303-309

  Tsuchiya, Kyoichiro ^a   Nakayama, Chisato ^a   Iwashima, Fumiko ^a   Sakai, Haruna ^a   Izumiyama, Hajime ^a   Doi, Masaru ^a   Hirata, Yukio ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Diabetes; Endothelium

Indexed keywords

ADULT; AGED; ARTICLE; CARDIOVASCULAR DISEASE; CASE CONTROL STUDY; FEMALE; HOMEOSTASIS; HUMAN; HYPERTENSION; INSULIN RESISTANCE; MALE; MIDDLE AGED; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOLOGY; PATHOPHYSIOLOGY; RISK FACTOR; VASCULAR ENDOTHELIUM; VASODILATATION;

ADULT; AGED; CARDIOVASCULAR DISEASES; CASE-CONTROL STUDIES; DIABETES MELLITUS, TYPE 2; ENDOTHELIUM, VASCULAR; FEMALE; HOMEOSTASIS; HUMANS; HYPERTENSION; INSULIN RESISTANCE; MALE; MIDDLE AGED; RISK FACTORS; VASODILATION;

EID: 41049088190     PISSN: 13403478     EISSN: 18803873     Source Type: Journal    
DOI: 10.5551/jat.E525     Document Type: Article

References (34)

1. Wilson PW and Grundy SM: The metabolic syndrome: practical guide to origins and treatment: Part I. Circulation, 2003; 108:1422-1424
2. Isomaa B, Almgren P, Tuomi T, Forsen B, Lahti K, Nissen M, Taskinen MR, and Groop L: Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care, 2001; 24:683-689
3. Despres JP, Lamarche B, Mauriege P, Cantin B, Dagenais GR, Moorjani S, and Lupien PJ: Hyperinsulinemia as an independent risk factor for ischemic heart disease. N Engl J Med, 1996; 334:952-957
4. Zimmet P, Magliano D, Matsuzawa Y, Alberti G, and Shaw J: The metabolic syndrome: a global public health problem and a new definition. J Atheroscler Thromb, 2005; 12:295-300
5. Deanfield JE, Halcox JP, and Rabelink TJ: Endothelial function and dysfunction: testing and clinical relevance. Circulation, 2007; 115:1285-1295
6. Deedwania PC: Metabolic syndrome and vascular disease: is nature or nurture leading the new epidemic of cardiovascular disease? Circulation, 2004; 109:2-4
7. Celermajer DS, Sorensen KE, Gooch VM, Spiegelhalter DJ, Miller OI, Sullivan ID, Lloyd JK, and Deanfield JE: Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet, 1992; 340:1111-1115
8. Celermajer DS, Sorensen KE, Bull C, Robinson J, and Deanfield JE: Endothelium-dependent dilation in the systemic arteries of asymptomatic subjects relates to coronary risk factors and their interaction. J Am Coll Cardiol, 1994; 24:1468-1474
9. Thorne S, Mullen MJ, Clarkson P, Donald AE, and Deanfield JE: Early endothelial dysfunction in adults at risk from atherosclerosis: different responses to L-arginine. J Am Coll Cardiol, 1998; 32:110-116
10. Panza JA, Quyyumi AA, Brush JE Jr., and Epstein SE: Abnormal endothelium-dependent vascular relaxation in patients with essential hypertension. N Engl J Med, 1990; 323:22-27
11. Creager MA, Cooke JP, Mendelsohn ME, Gallagher SJ, Coleman SM, Loscalzo J, and Dzau VJ: Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans. J Clin Invest, 1990; 86:228-234
12. Matsuzawa Y: Metabolic syndrome-definition and diagnostic criteria in Japan. J Atheroscler Thromb, 2005; 12:301
13. Sorensen KE, Celermajer DS, Spiegelhalter DJ, Georgakopoulos D, Robinson J, Thomas O, and Deanfield JE: Non-invasive measurement of human endothelium dependent arterial responses: accuracy and reproducibility. Br Heart J, 1995; 74:247-253
14. Tomiyama H, Yamashina A, Arai T, Hirose K, Koji Y, Chikamori T, Hori S, Yamamoto Y, Doba N, and Hinohara S: Influences of age and gender on results of noninvasive brachial-ankle pulse wave velocity measurement-a survey of 12517 subjects. Atherosclerosis, 2003; 166:303-309
15. Emoto M, Nishizawa Y, Maekawa K, Hiura Y, Kanda H, Kawagishi T, Shoji T, Okuno Y, and Morii H: Homeostasis model assessment as a clinical index of insulin resistance in type 2 diabetic patients treated with sulfonylureas. Diabetes Care, 1999; 22:818-822
16. Williams SB, Cusco JA, Roddy MA, Johnstone MT, and Creager MA: Impaired nitric oxide-mediated vasodilation in patients with non-insulin-dependent diabetes mellitus. J Am Coll Cardiol, 1996; 27:567-574
17. Steinberg HO, Chaker H, Learning R, Johnson A, Brechtel G, and Baron AD: Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance. J Clin Invest, 1996; 97:2601-2610
18. Ross R: Atherosclerosis-an inflammatory disease. N Engl J Med, 1999; 340:115-126
19. Barac A, Campia U, and Panza JA: Methods for evaluating endothelial function in humans. Hypertension, 2007; 49:748-760
20. Raitakari OT and Celermajer DS: Testing for endothelial dysfunction. Ann Med, 2000; 32:293-304
21. Anderson TJ, Uehata A, Gerhard MD, Meredith IT, Knab S, Delagrange D, Lieberman EH, Ganz P, Creager MA, Yeung AC, and Selwyn AP: Close relation of endothelial function in the human coronary and peripheral circulations. J Am Coll Cardiol, 1995; 26:1235-1241
22. Corretti MC, Anderson TJ, Benjamin EJ, Celermajer D, Charbonneau F, Creager MA, Deanfield J, Drexler H, Gerhard-Herman M, Herrington D, Vallance P, Vita J, and Vogel R: Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. J Am Coll Cardiol, 2002; 39:257-265
23. Gokce N, Keaney JF Jr., Hunter LM, Watkins MT, Nedeljkovic ZS, Menzoian JO, and Vita JA: Predictive value of noninvasively determined endothelial dysfunction for long-term cardiovascular events in patients with peripheral vascular disease. J Am Coll Cardiol, 2003; 41:1769-1775
24. Brevetti G, Silvestro A, Schiano V, and Chiariello M: Endothelial dysfunction and cardiovascular risk prediction in peripheral arterial disease: additive value of flow-mediated dilation to ankle-brachial pressure index. Circulation, 2003; 108:2093-2098
25. O'Rourke MF and Mancia G: Arterial stiffness. J Hypertens, 1999; 17:1-4
26. Behrendt D and Ganz P: Endothelial function. From vascular biology to clinical applications. Am J Cardiol, 2002; 90:40L-48L
27. Simon A, Gariepy J, Chironi G, Megnien JL, and Levenson J: Intima-media thickness: a new tool for diagnosis and treatment of cardiovascular risk. J Hypertens, 2002; 20:159-169
28. Celermajer DS, Sorensen KE, Georgakopoulos D, Bull C, Thomas O, Robinson J, and Deanfield JE: Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults. Circulation, 1993; 88:2149-2155
29. Vita JA, Treasure CB, Nabel EG, McLenachan JM, Fish RD, Yeung AC, Vekshtein VI, Selwyn AP, and Ganz P: Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease. Circulation, 1990; 81:491-497
30. Hashimoto M, Kozaki K, Eto M, Akishita M, Ako J, Iijima K, Kim S, Toba K, Yoshizumi M, and Ouchi Y: Association of coronary risk factors and endothelium-dependent flow-mediated dilatation of the brachial artery. Hypertens Res, 2000; 23:233-238
31. Bonora E, Targher G, Formentini G, Calcaterra F, Lombardi S, Marini F, Zenari L, Saggiani F, Poli M, Perbellini S, Raffaelli A, Gemma L, Santi L, Bonadonna RC, and Muggeo M: The Metabolic Syndrome is an independent predictor of cardiovascular disease in Type 2 diabetic subjects. Prospective data from the Verona Diabetes Complications Study. Diabet Med, 2004; 21:52-58
32. Rask-Madsen C, Dominguez H, Ihlemann N, Hermann T, Kober L, and Torp-Pedersen C: Tumor necrosis factor-alpha inhibits insulin's stimulating effect on glucose uptake and endothelium-dependent vasodilation in humans. Circulation, 2003; 108:1815-1821
33. Tan KC, Xu A, Chow WS, Lam MC, Ai VH, Tam SC, and Lam KS: Hypoadiponectinemia is associated with impaired endothelium-dependent vasodilation. J Clin Endocrinol Metab, 2004; 89:765-769
34. Ceriello A, Taboga C, Tonutti L, Quagliaro L, Piconi L, Bais B, Da Ros R, and Motz E: Evidence for an independent and cumulative effect of postprandial hypertriglyceridemia and hyperglycemia on endothelial dysfunction and oxidative stress generation: effects of short- and long-term simvastatin treatment. Circulation, 2002; 106:1211-1218