Immunohistochemical detection of connexin36 in sympathetic preganglionic and somatic motoneurons in the adult rat

Autonomic Neuroscience: Basic and Clinical

Volumn 139, Issue 1-2, 2008, Pages 15-23

  Marina, Nephtali ^a   Becker, David L ^a   Gilbey, Michael P ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Gap junctions; Motoneurons; Rhythmic; Spinal cord; Sympathetic

Indexed keywords

CHOLINE ACETYLTRANSFERASE; CONNEXIN 36;

ANIMAL TISSUE; ARTICLE; BRAIN REGION; DENDRITIC CELL; GAP JUNCTION; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MOTONEURON; NONHUMAN; PREGANGLIONIC NERVE; PRIORITY JOURNAL; PROTEIN ANALYSIS; RAT; SPINAL CORD VENTRAL HORN; STAINING; SYMPATHETIC NERVE; THORACIC SPINAL CORD; TISSUE SECTION;

ANIMALS; AUTONOMIC FIBERS, PREGANGLIONIC; CHOLINE O-ACETYLTRANSFERASE; CONNEXINS; MALE; MOTOR NEURONS; OLIVARY NUCLEUS; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD;

EID: 41049083299     PISSN: 15660702     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.autneu.2007.12.004     Document Type: Article

References (39)

1. Becker D.L., and Navarrete R. Dye coupling between lumbar motoneurones in the embryonic and neonatal rat spinal cord: an in vitro study. J. Physiol. 423 (1990) 98P
2. Belluardo N., Mudô G., Trovato-Salinaro A., Le Gurun S., Charollais A., Serre-Beinier V., Amato G., Haefliger J.A., Meda P., and Condorelli D.F. Expression of connexin36 in the adult and developing rat brain. Brain Res. 865 (2000) 121-138
3. Bennett M.V. Gap junctions as electrical synapses. J. Neurocytol. 26 (1997) 349-366
4. Bennett M.V., and Zukin R.S. Electrical coupling and neuronal synchronization in the mammalian brain. Neuron. 41 (2004) 495-511
5. Bittman K., Becker D.L., Cicirata F., and Parnavelas J.G. Connexin expression in homotypic and heterotypic cell coupling in the developing cerebral cortex. J Comp Neurol. 443 (2002) 201-212
6. Buhl D.L., Harris K.D., Hormuzdi S.G., Monyer H., and Buzsaki G. Selective impairment of hippocampal gamma oscillations in connexin-36 knock-out mouse in vivo. J Neurosci. 23 (2003) 1013-1018
7. Cabot J.B. Sympathetic preganglionic neurons, cytoarchitecture, ultrastructure and biophysical properties. In: Lowey A.D., and Spyer K.M. (Eds). Central Regulation of Autonomic Functions (1990), Oxford University Press 44-67
8. Cabot J.B., Alessi V., Carroll J., and Ligorio M. Spinal cord lamina V and lamina VII interneuronal projections to sympathetic preganglionic neurons. J Comp Neurol. 347 (1994) 515-530
9. Chang Q., Gonzalez M., Pinter M.J., and Balice-Gordon R.J. Gap junctional coupling and patterns of connexin expression among neonatal rat lumbar spinal motor neurons. J Neurosci. 19 (1999) 10813-10828
10. Chang Q., Pereda A., Pinter M.J., and Balice-Gordon R.J. Nerve injury induces gap junctional coupling among axotomized adult motor neurons. J Neurosci. 20 (2000) 674-684
11. Christie J.M., Bark C., Hormuzdi S.G., Helbig I., Monyer H., and Westbrook G.L. Connexin36 mediates spike synchrony in olfactory bulb glomeruli. Neuron. 46 (2005) 761-772
12. Condorelli D.F., Belluardo N., Trovato-Salinaro A., and Mudo G. Expression of Cx36 in mammalian neurons. Brain Res Brain Res Rev. 32 (2000) 72-85
13. De Zeeuw C.I., Chorev E., Devor A., Manor Y., Van Der Giessen R.S., De Jeu M.T., Hoogenraad C.C., Bijman J., Ruigrok T.J., French P., Jaarsma D., Kistler W.M., Meier C., Petrasch-Parwez E., Dermietzel R., Sohl G., Gueldenagel M., Willecke K., and Yarom Y. Deformation of network connectivity in the inferior olive of connexin 36-deficient mice is compensated by morphological and electrophysiological changes at the single neuron level. J Neurosci. 23 (2003) 4700-4711
14. Deans M.R., Gibson J.R., Sellitto C., Connors B.W., and Paul D.L. Synchronous activity of inhibitory networks in neocortex requires electrical synapses containing connexin36. Neuron. 31 (2001) 477-485
15. Gogan P., Gueritaud J.P., Horcholle-Bossavit G., and Tyc-Dumont S. Direct excitatory interactions between spinal motoneurones of the cat. J Physiol. 272 (1977) 755-767
16. Hormuzdi S.G., Pais I., LeBeau F.E., Towers S.K., Rozov A., Buhl E.H., Whittington M.A., and Monyer H. Impaired electrical signaling disrupts gamma frequency oscillations in connexin 36-deficient mice. Neuron. 31 (2001) 487-495
17. Kiehn O., and Tresch M.C. Gap junctions and motor behavior. Trends Neurosci. 25 (2002) 108-115
18. Landisman C.E., Long M.A., Beierlein M., Deans M.R., Paul D.L., and Connors B.W. Electrical synapses in the thalamic reticular nucleus. J Neurosci. 22 (2002) 1002-1009
19. Lee I.H., Lindqvist E., Kiehn O., Widenfalk J., and Olson L. Glial and neuronal connexin expression patterns in the rat spinal cord during development and following injury. J Comp Neurol. 489 (2005) 1-10
20. Leznik E., and Llinas R. Role of gap junctions in synchronized neuronal oscillations in the inferior olive. J Neurophysiol. 94 (2005) 2447-2456
21. Logan S.D., Pickering A.E., Gibson I.C., Nolan M.F., and Spanswick D. Electrotonic coupling between rat sympathetic preganglionic neurons in vitro. J Physiol. 495 (1996) 491-502
22. Long M.A., Deans M.R., Paul D.L., and Connors B.W. Rhythmicity without synchrony in the electrically uncoupled inferior olive. J Neurosci. 22 (2002) 10898-10905
23. Marina N., Morales T., Diaz N., and Mena F. Suckling-induced activation of neural c-fos expression at lower thoracic rat spinal cord segments. Brain Res. 954 (2002) 100-114
24. Marina N., Taheri M., and Gilbey M.P. Generation of a physiological sympathetic motor rhythm in the rat following spinal application of 5-HT. J Physiol. 571 (2006) 441-450
25. Martin P.E., and Evans W.H. Incorporation of connexins into plasma membranes and gap junctions. Cardiovasc Res. 62 (2004) 378-387
26. Matsumoto A., Arnold A.P., Zampighi G.A., and Micevych P.E. Androgenic regulation of gap junctions between motoneurons in the rat spinal cord. J Neurosci. 8 (1988) 4177-4183
27. Mentis G.Z., Diaz E., Moran L.B., and Navarrete R. Increased incidence of gap junctional coupling between spinal motoneurons following transient blockade of NMDA receptors in neonatal rats. J Physiol. 544 (2002) 757-764
28. Nagy J.I., Dudek F.E., and Rash J.E. Update on connexins and gap junctions in neurons and glia in the mammalian nervous system. Brain Res Brain Res Rev. 47 (2004) 191-215
29. Nolan M.F., Logan S.D., and Spanswick D. Electrophysiological properties of electrical synapses between rat sympathetic preganglionic neurones in vitro. J Physiol. 519 (1999) 753-764
30. Parenti R., Gulisano R.M., Zappala' A., and Cicirata F. Expression of connexin36 mRNA in adult rodent brain. Neuroreport 11 (2000) 1497-1502
31. Paxinos G., and Watson C. The Rat Brain in Stereotaxic Coordinates. 4th ed. (1998), Academic Press, San Diego Fig. 117-b
32. Placantonakis D.G., Bukovsky A.A., Aicher S.A., Kiem H.P., and Welsh J.P. Continuous electrical oscillations emerge from a coupled network: a study of the inferior olive using lentiviral knock-down of connexin36. J Neurosci. 26 19 (2006) 5008-5016 May 10
33. Qin M., Wang J.J., Cao R., Zhangh H., Duan L., Gao B., Xiong Y.F., Chen L.W., and Rao Z.R. The lumbar spinal cord glial cells actively modulate subcutaneous formalin induced hyperalgesia in the rat. Neurosci Res. 55 (2006) 442-450
34. Rash J.E., Staines W.A., Yasumura T., Patel D., Furman C.S., Stelmack G.L., and Nagy J.I. Immunogold evidence that neuronal gap junctions in adult rat brain and spinal cord contain connexin-36 but not connexin-32 or connexin-43. Proc Natl Acad Sci. 97 (2000) 7573-7578
35. Shen E., and Dun M.J. Neonate rat sympathetic preganglionic neurons intracellularly labelled with lucifer yellow in thin spinal cord slices. J Auton Nerv Syst. 29 (1990) 247-254
36. Tresch M.C., and Kiehn O. Motor coordination without action potentials in the mammalian spinal cord. Nat Neurosci. 3 (2000) 593-599
37. van der Want J.J., Gramsbergen A., Ijkema-Paassen J., de Weerd H., and Liem R.S. Dendro-dendritic connections between motoneurons in the rat spinal cord: an electron microscopic investigation. Brain Res. 779 (1998) 342-345
38. Walton K.D., and Navarrete R. Postnatal changes in motoneurone electrotonic coupling studied in the in vitro rat lumbar spinal cord. J Physiol. 433 (1991) 283-305
39. Yeager M., Unger V.M., and Falk M.M. Synthesis, assembly and structure of gap junction intercellular channels. Curr Opin Struct Biol. 8 (1998) 517-524