Nerve injury induces gap junctional coupling among axotomized adult motor neurons

Journal of Neuroscience

Volumn 20, Issue 2, 2000, Pages 674-684

  Chang, Qiang ^a   Pereda, Alberto ^b   Pinter, Martin J ^c   Balice Gordon, Rita J ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Axotomy; Connexin; Gap junction; Injury; Motor neuron; Nerve; Skeletal muscle

Indexed keywords

GAP JUNCTION PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CAT; CONTROLLED STUDY; GAP JUNCTION; INTERNEURON; LUMBAR SPINE; MOTONEURON; NERVE FIBER TRANSECTION; NERVE INJURY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PYRAMIDAL NERVE CELL; SECOND MESSENGER; SKELETAL MUSCLE; STIMULUS SECRETION COUPLING; SYNAPTIC TRANSMISSION;

EID: 0034651094     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.20-02-00674.2000     Document Type: Article

References (58)

1. Aldskogius H, Kozlova EN (1998) Central neuron-glial and glial-glial interactions following axon injury. Prog Neurobiol 55:1-26.
2. Baker R, Llinas R (1971) Electrotonic coupling between neurones in the rat mesencephalic nucleus. J Physiol (Lond) 212:45-63.
3. Balice-Gordon RJ, Pereda A, Pinter MJ (1996) Functional gap junctions couple motor neurons in development and reinnervation. Soc Neurosci Abstr 22:1487.
4. Barry JA, Ribchester RR (1995) Persistent polyneuronal innervation in partially denervated rat muscle after reinnervation and recovery from prolonged nerve conduction block. J Neurosci 15:6327-6339.
5. Beyer EC, Paul DL, Goodenough DA (1987) Connexin43: a protein from rat heart homologous to a gap junction protein from liver. J Cell Biol 105:2621-2629.
6. Bruzzone R, Ressot C (1997) Connexins, gap junctions and cell-cell signalling in the nervous system. Eur J Neurosci 9:1-6.
7. Burke RE, Dum RP, Fleshman JW, Glenn LL, Lev-Tov A, O'Donovan MJ, Pinter MJ (1982) A HRP study of the relation between cell size and motor unit type in cat ankle extensor motoneurons. J Comp Neurol 209:17-28.
8. Carlson J, Lais AC, Dyck PJ (1979) Axonal atrophy from permanent peripheral axotomy in adult cat. J Neuropathol Exp Neurol 38:579-585.
9. Chandross KJ, Kessler JA, Cohen RI, Simburger E, Spray DC, Bieri P, Dermietzel R (1996) Altered connexin expression after peripheral nerve injury. Mol Cell Neurosci 7:501-518.
10. Chang Q, Balice-Gordon RJ (1997) Developmental regulation of connexin expression in motor neurons. Soc Neurosci Abstr 23:1677.
11. Chang Q, Gonzalez M, Pinter MJ, Balice-Gordon RJ (1999) Gap junctional coupling and connexin expression among neonatal rat lumbar spinal motor neurons. J Neurosci 19:10813-10828.
12. Condorelli DF, Parenti R, Spinella F, Salinaro AT, Belluardo N, Cardile V, Cicirata F (1998) Cloning of a new gap junction gene (Cx36) highly expressed in mammalian brain neurons. Eur J Neurosci 10:1202-1208.
13. Connors BW, Benardo LS, Prince DA (1983) Coupling between neurons of the developing rat neocortex. J Neurosci 3:773-782.
14. Cope TC, Pinter MJ (1995) The size principle: still working after all these years. News Physiol Sci 10:280-286.
15. Dermietzel R, Hofstadter F (1998) Gap junctions in health and disease. Virchows Arch 432:177-186.
16. Dermietzel R, Spray DC (1993) Gap junctions in the brain: where, what type, how many and why? Trends Neurosci 16:186-192.
17. Fallon MB, Nathanson MH, Mennone A, Saez JC, Burgstahler AD, Anderson JM (1995) Altered expression and function of hepatocyte gap junctions after common bile duct ligation in the rat. Am J Physiol 268:C1186-C1194.
18. Frank E (1993) New life in an old structure: the development of synaptic pathways in the spinal cord. Curr Opin Neurobiol 3:82-86.
19. Fulton BP, Walton K (1986) Electrophysiological properties of neonatal rat motoneurones studied in vitro. J Physiol (Lond) 370:651-678.
20. Fulton BP, Miledi R, Takahashi T (1980) Electrical synapses between motoneurons in the spinal cord of the newborn rat. Proc R Soc Lond B Biol Sci 208:115-120.
21. Funakoshi H, Frisen J, Barbany G, Timmusk T, Zachrisson O, Verge VM, Persson H (1993) Differential expression of mRNAs for neurotrophins and their receptors after axotomy of the sciatic nerve. J Cell Biol 123:455-465.
22. Gogan P, Oueritaud JP, Horcholle-Bossavit G, Tyc-Dumont S (1974) Electrotonic coupling between motoneurones in the abducens nucleus of the cat. Exp Brain Res 21:139-154.
23. Goliger JA, Paul DL (1995) Wounding alters epidermal connexin expression and gap junction-mediated intercellular communication. Mol Biol Cell 6:1491-1501.
24. Goodman CS, Shatz CJ (1993) Developmental mechanisms that generate precise patterns of neuronal connectivity. Neuron 10:77-98.
25. Gustafsson B, Pinter MJ (1984) Effects of axotomy on the distribution of passive electrical properties of cat motoneurones. J Physiol (Lond) 356:433-442.
26. Haefliger JA, Bruzzone R, Jenkins NA, Gilbert DJ, Copeland NG, Paul DL (1992) Four novel members of the connexin family of gap junction proteins. Molecular cloning, expression, and chromosome mapping. J Biol Chem 267:2057-2064.
27. Kandler K, Katz LC (1998) Coordination of neuronal activity in developing visual cortex by gap junction-mediated biochemical communication. J Neurosci 18:1419-1427.
28. Kita H, Armstrong W (1991) A biotin-containing compound N-(2-aminoethyl)biotinamide for intracellular labeling and neuronal tracing studies: comparison with biocytin. J Neurosci Methods 37:141-150.
29. Koliatsos VE, Price DL, Clatterbuck RE (1990) Motor neurons in Onuf's nucleus and its rat homologues express the p75 nerve growth factor receptor: sexual dimorphism and regulation by axotomy. J Comp Neurol 345:510-527.
30. Korn H, Sotelo C, Bennett MVL (1977) The lateral vestibular nucleus of the toadfish Opsanus tau: ultrastructural and electrophysiological observations with special reference to clectrotonic transmission. Neuroscience 2:851-884.
31. Kumar NM (1999) Molecular biology of the interactions between connexins. Novartis Found Symp 219:6-16.
32. Kunzelmann P, Blumcke I, Traub O, Dermietzel R, Willecke K (1997) Coexpression of connexin45 and -32 in oligodendrocytes of rat brain. J Neurocytol 26:17-22.
33. Li J, Hertzberg EL, Nagy JI (1997) Connexin32 in oligodendrocytes and association with myelinated fibers in mouse and rat brain. J Comp Neurol 379:571-591.
34. Llinas R, Sasaki K (1989) The functional organization of the olivocerebellar system as examined by multiple purkinje cell recordings. Eur J Neurosci 1:587-602.
35. MacVicar BA, Dudek FE (1981) Electrotonic coupling between pyramidal cells: a direct demonstration in rat hippocampal slices. Science 213:782-784.
36. Mann-Metzer P, Yarom Y (1999) Electrotonic coupling interacts with intrinsic properties to generate synchronized activity in cerebellar networks of inhibitory interneurons. J Neurosci 19:3298-3306.
37. Matic M, Petrov IN, Rosenfeld T, Wolosin JM (1997) Alterations in connexin expression and cell communication in healing corncal epithelium. Invest Ophthalmol Vis Sci 38:600-609.
38. Matthews MA, Willis WD, Williams V (1971) Dendrite bundles in lamina IX of cat spinal cord: a possible source for electrical interaction between motoneurons? Anat Rec 171:313-327.
39. Nadarajah B, Thomaidou D, Evans WH, Parnavelas JG (1996) Gap junctions in the adult cerebral cortex: regional differences in their distribution and cellular expression of connexins. J Comp Neurol 376:326-342.
40. Nagaoka T, Oyamada M, Okajima S, Takamatsu T (1999) Differential expression of gap junction proteins connexin26, 32, and 43 in normal and crush-injured rat sciatic nerves. Close relationship between connexin43 and occludin in the perineurium. J Histochem Cytochem 47:937-948.
41. Pastor A, Kremer M, Moller T, Kettenmann H, Dermietzel R (1998) Dye coupling between spinal cord oligodendrocytes: differences in coupling efficiency between gray and white matter. Glia 24:108-120.
42. Paul DL (1986) Molecular cloning of cDNA for rat liver gap junction protein. J Cell Biol 103:123-134.
43. Pinter MJ, Vanden Noven S (1989) Effects of preventing reinnervation on axotomized spinal motoneurons in the cat. I. Motoneuron electrical properties. J Neurophysiol 62:311-324.
44. Ribchester RR (1988) Activity-dependent and -independent synaptic interactions during reinnervation of partially denervated rat muscle. J Physiol (Lond) 401:53-75.
45. Rich MM, Lichtman JW (1989) In vivo visualization of pre- and postsynaptic changes during synapse elimination in reinnervated mouse muscle. J Neurosci 9:1781-1805.
46. Rohlmann A, Laskawi R, Hofer A, Dobo E, Dermietzel R, Wolff JR (1993) Facial nerve lesions lead to increased immunostaining of the astrocytic gap junction protein (connexin 43) in the corresponding facial nucleus of rats. Neurosci Lett 154:206-208.
47. Rohlmann A, Laskawi R, Hofer A, Dermietzel R, Wolff JR (1994) Astrocytes as rapid sensors of peripheral axotomy in the facial nucleus of rats. NeuroReport 5:409-412.
48. Romanes GJ (1951) The motor cell columns of the lumbo-sacral spinal cord of the cat. J Anat 85:313-358.
49. Schwarz HJ, Chang YS, Hennemann H, Dahl E, Lalley PA, Willecke K (1992) Chromosomal assignments of mouse connexin genes, coding for gap junctional proteins, by somatic cell hybridization. Somat Cell Mol Genet 18:351-359.
50. Steinberg TH, Civitelli R, Geist ST, Robertson AJ, Hick E, Veenstra RD, Wang HZ, Warlow PM, Westphale EM, Laing JG, Beyer EC (1994) Connexin43 and connexin45 form gap junctions with different molecular permeabilities in osteoblastic cells. EMBO J 13:744-750.
51. Swett JE, Wikholm RP, Blanks RH, Swett AL, Conley LC (1986) Motoneurons of the rat sciatic nerve. Exp Neurol 93:227-252.
52. Theriault E, Frankenstein UN, Hertzberg EL, Nagy JI (1997) Connexin43 and astrocytic gap junctions in the rat spinal cord after acute compression injury. J Comp Neurol 382:199-214.
53. Titmus MJ, Faber DS (1990) Axotomy-induced alterations in the electrophysiological characteristics of neurons. Prog Neurobiol 35:1-51.
54. Ulfhake B, Kellerth JO (1982) Does alpha-motoneurone size correlate with motor unit type in cat triceps surae? Brain Res 251:201-209.
55. van der Want JJ, Gramsbergen A, Ijkema-Paassen J, de Weerd H, Liem RS (1998) Dendro-dendritic connections between motoneurons in the rat spinal cord: an electron microscopic investigation. Brain Res 779:342-345.
56. Walton KD, Navarette R (1991) Postnatal changes in motoneurone electrotonic coupling studied in the in vitro rat lumbar spinal cord. J Physiol (Lond) 433:283-305.
57. Wu W (1996) Potential roles of gene expression change in adult rat spinal motoneurons following axonal injury: a comparison among c-jun, off-affinity nerve growth factor receptor (LNGFR), and nitric oxide synthase (NOS). Exp Neurol 141:190-200.
58. Zhang JT, Nicholson BJ (1989) Sequence and tissue distribution of a second protein of hepatic gap junctions, Cx26, as deduced from its cDNA. J Cell Biol 109:3391-3401.