Design and synthesis of biologically active analogues of vitamin K2: Evaluation of their biological activities with cultured human cell lines

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 6, 2008, Pages 3108-3117

  Suhara, Yoshitomo ^a   Hirota, Yoshihisa ^a   Nakagawa, Kimie ^a   Kamao, Maya ^a   Tsugawa, Naoko ^a   Okano, Toshio ^a  

^a KOBE PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Oxidation; K acid; Menaquinone 4; Metabolite; Vitamin K

Indexed keywords

12 (1,4 DIHYDRO 2 METHYL 1,4 DIOXANAPHTHALEN 3 YL) 2,6,10 TRIMETHYLDODECA 2,6,10 TRIENAL; 16 (1,4 DIHYDRO 2 METHYL 1,4 DIOXONAPHTHALEN 3 YL) 2,6,10,14 TETRAMETHYLHEXADECA 2,6,10,14 TETRAENAL; 2 (12 HYDROXY 3,7,11 TRIMETHYLDODECA 2,6,10 TRIENYL) 3 METHYLNAPHTHALENE 1,4 DIONE; 2 (16 HYDROXY 3,7,11,15 TETRAMETHYLHEXADECA 2,6,10,14 TETRAENYL) 3 METHYLNAPHTHALENE 1,4 DIONE; 2 (8 HYDROXY 3,7 DIMETHYLOCTA 2,6 DIENYL)3 METHYLNAPHTHALENE 1,4 DIONE; 8 (1,4 DIHYDRO 2 METHYL 1,4 DIOXONAPHTHALEN 3 YL) 2,6 DIMETHYLOCTA 2,6 DIENAL; FARNOQUINONE; MENAQUINONE; MENATETRENONE; PHYTOMENADIONE; UNCLASSIFIED DRUG; VITAMIN K GROUP;

APOPTOSIS; ARTICLE; CELL CULTURE; DRUG ACTIVITY; DRUG DESIGN; DRUG SYNTHESIS; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION;

APOPTOSIS; CELL LINE; DRUG DESIGN; HUMANS; STRUCTURE-ACTIVITY RELATIONSHIP; VITAMIN K 2;

EID: 40949163426     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.12.025     Document Type: Article

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