Blockade of OX40 Signals Enhance Survival of Xenoislet Grafts in Spontaneously Diabetic NOD Mice

Transplantation Proceedings

Volumn 40, Issue 2, 2008, Pages 483-485

  Honkanen Scott, M ^a   Johnson, J ^a   Hering, B ^a   Bansal Pakala, P ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; IMMUNOGLOBULIN; OX40 LIGAND; OX40 LIGAND ANTIBODY; STREPTOZOCIN; UNCLASSIFIED DRUG;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FEMALE; GLUCOSE BLOOD LEVEL; GRAFT REJECTION; GRAFT SURVIVAL; INSULIN DEPENDENT DIABETES MELLITUS; KIDNEY CAPSULE; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; PANCREAS; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; SPLEEN; STATISTICAL SIGNIFICANCE; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; XENOGRAFT;

ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; FEMALE; GRAFT SURVIVAL; IMMUNOCONJUGATES; IMMUNOSUPPRESSIVE AGENTS; ISLETS OF LANGERHANS TRANSPLANTATION; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED NOD; TUMOR NECROSIS FACTORS;

EID: 40949152873     PISSN: 00411345     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.transproceed.2008.02.020     Document Type: Article

References (8)

1. Hering B.J., Wijkstrom M., Graham M.I., et al. Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates. Nat Med 12 (2006) 301
2. Kirchhof N., Shibata S., Wijkstrom M., et al. Reversal of diabetes in non-immunosuppressed rhesus macaques by intraportal porcine islet xenografts precedes acute cellular rejection. Xenotransplantation 11 (2004) 396
3. Watts T.H. TNF/TNFR family members in costimulation of T cell responses. Annu Rev Immunol 23 (2005) 23
4. Pakala S.V., Bansal-Pakala P., Halteman B.S., et al. Prevention of diabetes in NOD mice at a late stage by targeting OX40/OX40 ligand interactions. Eur J Immunol 34 (2004) 3039
5. Vu M.D., Clarkson M.R., Yagita H., et al. Critical, but conditional, role of OX40 in memory T cell-mediated rejection. J Immunol 176 (2006) 1394
6. Wang G.M., Yang Y., Jin Y.Z., et al. Blockade of both CD28/B7 and OX40/OX40L co-stimulatory signal pathways prolongs the survival of islet xenografts. Transplant Proc 37 (2005) 4449
7. Guo Z., Wu T., Kirchhof N., et al. Immunotherapy with nondepleting anti-CD4 monoclonal antibodies but not CD28 antagonists protects islet graft in spontaneously diabetic nod mice from autoimmune destruction and allogeneic and xenogeneic graft rejection. Transplantation 71 (2001) 1656
8. Tang Q., Boden E.K., Henriksen K.J., et al. Distinct roles of CTLA-4 and TGF-beta in CD4+CD25+ regulatory T cell function. Eur J Immunol 34 (2004) 2996