Cyclooxygenase-2 Expression as a Predictor of Para-Aortic Lymph Node Recurrence in Uterine Cervical Cancer

International Journal of Radiation Oncology Biology Physics

Volumn 70, Issue 5, 2008, Pages 1516-1521

  Kim, Jun Sang ^a,b   Li, Shengjin ^a   Kim, Jin Man ^a,b   Yeo, Seung Gu ^a   Kim, Ki Hwan ^a   Cho, Moon June ^a,b  

^a Chungnam National University College of Medicine   (South Korea)

^b Chungnam National University   (South Korea)

Author keywords

Cyclooxygenase 2; Para aortic nodes; Uterine cervix cancer

Indexed keywords

PATIENT MONITORING; RADIOTHERAPY; TUMORS;

CYCLOOXYGENASE; PARA-AORTIC NODES; UTERINE CERVIX CANCER;

ONCOLOGY;

CYCLOOXYGENASE 2; FORMALDEHYDE; MONOCLONAL ANTIBODY; PACLITAXEL; PARAFFIN;

ADULT; AGED; ARTICLE; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER STAGING; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; HUMAN; HUMAN CELL; HUMAN TISSUE; PARAAORTIC LYMPH NODE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR BIOPSY; UTERINE CERVIX CANCER;

AORTA; CYCLOOXYGENASE 2; FEMALE; HUMANS; LOGISTIC MODELS; LYMPHATIC METASTASIS; MATCHED-PAIR ANALYSIS; MIDDLE AGED; TUMOR MARKERS, BIOLOGICAL; UTERINE CERVICAL NEOPLASMS;

EID: 40949141847     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2007.08.048     Document Type: Article

References (30)

1. Fagundes H., Perez C.A., Grigsby P.W., et al. Distant metastases after irradiation alone in carcinoma of the uterine cervix. Int J Radiat Oncol Biol Phys 24 (1992) 197-204
2. Grigsby P.W., Vest M.L., and Perez C.A. Recurrent carcinoma of the cervix exclusively in the paraaortic nodes following radiation therapy. Int J Radiat Oncol Biol Phys 28 (1994) 451-455
3. Kim J.S., Kim J.S., Kim S.Y., et al. Hyperfractionated radiotherapy with concurrent chemotherapy for para-aortic lymph node recurrence in carcinoma of the cervix. Int J Radiat Oncol Biol Phys 55 (2003) 16-20
4. Niibe Y., Kazumoto T., Toita T., et al. Frequency and characteristics of isolated para-aortic lymph node recurrence in patients with uterine cervical carcinoma in Japan: A multi-institutional study. Gynecol Oncol 103 (2006) 435-438
5. Ryu H.S., Chang K.H., Yang H.W., et al. High cyclooxygenase-2 expression in stage IB cervical cancer with lymph node metastasis or parametrial Invasion. Gynecol Oncol 76 (2000) 320-325
6. Kim Y.B., Kim G.E., Cho N.H., et al. Overexpression of cyclooxygenase-2 is associated with a poor prognosis in patients with squamous cell carcinoma of the uterine cervix treated with radiation and concurrent chemotherapy. Cancer 95 (2002) 531-539
7. Kim H.J., Wu H.G., Park I.A., et al. SW. High cyclooxygenase-2 expression is related with distant metastasis in cervical cancer treated with radiotherapy. Int J Radiat Oncol Biol Phys 55 (2003) 1247-1253
8. Gaffney D.K., Holden J., Davis M., et al. Elevated cyclooxygenase-2 expression correlates with diminished survival in carcinoma of the cervix treated with radiotherapy. Int J Radiat Oncol Biol Phys 49 (2001) 1213-1217
9. Tomozawa S., Tsuno N.H., Sunami E., et al. Cyclooxygenase-2 overexpression correlates with tumour recurrence, especially haematogenous metastasis, of colorectal cancer. Br J Cancer 83 (2000) 324-328
10. Xi H., Baldus S.E., Warnecke-Eberz U., et al. High cyclooxygenase-2 expression following neoadjuvant radiochemotherapy is associated with minor histopathologic response and poor prognosis in esophageal cancer. Clin Cancer Res 11 (2005) 8341-8347
11. Cohen B.L., Gomez P., Omori Y., et al. Cyclooxygenase-2 (COX-2) expression is an independent predictor of prostate cancer recurrence. Int J Cancer 119 (2006) 1082-1087
12. Fowler J.F. Brief summary of radiobiological principles in fractionated radiotherapy. Semin Radiat Oncol 2 (1992) 16-21
13. Remmele W., and Stegner H.E. Recommendation for uniform definition of an immunoreactive score (IRS) for immunohistochemical estrogen receptor detection (ER-ICA) in breast cancer tissue. Pathologe 8 (1987) 138-140
14. Kersemaekers A.M., Fleuren G.J., Kenter G.G., et al. Oncogene alterations in carcinomas of the uterine cervix: Overexpression of the epidermal growth factor receptor is associated with poor prognosis. Clin Cancer Res 5 (1999) 577-586
15. Masunaga R., Kohno H., Dhar D.K., et al. Cyclooxygenase-2 expression correlates with tumor neovascularization and prognosis in human colorectal carcinoma patients. Clin Cancer Res 6 (2000) 4064-4068
16. Scambia G., Benedetti Panici P., Foti E., et al. Squamous cell carcinoma antigen: Prognostic significance and role in the monitoring of neoadjuvant chemotherapy response in cervical cancer. J Clin Oncol 12 (1994) 2309-2316
17. Bolli J.A., Doering D.L., Bosscher J.R., et al. Squamous cell carcinoma antigen: Clinical utility in squamous cell carcinoma of the uterine cervix. Gynecol Oncol 55 (1994) 169-173
18. Kulkarni S., Rader J.S., Zhang F., et al. Cyclooxygenase-2 is overexpressed in human cervical cancer. Clin Cancer Res 7 (2001) 429-434
19. Ferrandina G., Ranelletti F.O., Legge F., et al. Cyclooxygenase-2 (COX-2) expression in locally advanced cervical cancer patients undergoing chemoradiation plus surgery. Int J Radiat Oncol Biol Phys 55 (2003) 21-27
20. Kang S., Kim M.H., Park I.A., et al. Elevation of cyclooxygenase-2 is related to lymph node metastasis in adenocarcinoma of uterine cervix. Cancer Lett 237 (2006) 305-311
21. Remmele W., and Schicketanz K.H. Immunohistochemical determination of estrogen and progesterone receptor content in human breast cancer: Computer-assisted image analysis (QIC score) vs. subjective grading (IRS). Pathol Res Pract 189 (1993) 862-866
22. Sarian L.O., Derchain S.F., Yoshida A., et al. Expression of cyclooxygenase-2 (COX-2) and Ki67 as related to disease severity and HPV detection in squamous lesions of the cervix. Gynecol Oncol 102 (2006) 537-541
23. Fux R., Schwab M., Thon K.P., et al. Cyclooxygenase-2 expression in human colorectal cancer is unrelated to overall patient survival. Clin Cancer Res 11 (2005) 4754-4760
24. Sheehan K.M., Sheahan K., O'Donoghue D.P., et al. The relationship between cyclooxygenase-2 expression and colorectal cancer. JAMA 282 (1999) 1254-1257
25. Chou H.H., Wang C.C., Lai C.H., et al. Isolated paraaortic lymph node recurrence after definitive irradiation for cervical carcinoma. Int J Radiat Oncol Biol Phys 51 (2001) 442-448
26. Yoo H., Kim M., Cho C., et al. Isolated periaortic lymph node metastasis from uterine cervical cancer treated by stereotactic radiation therapy using CyberKnife. [Abstract]. Int J Radiat Oncol Biol Phys 63 Suppl. 1 (2005) S342
27. Chatani M., Matayoshi Y., Masaki N., et al. Prophylactic irradiation of para-aortic lymph nodes in carcinoma of the uterine cervix: A prospective randomized study. Strahlenther Onkol 171 (1995) 655-660
28. Rotman M., Pajak T.F., Choi K., et al. Prophylactic extended-field irradiation of para-aortic lymph nodes in stages IIB and bulky IB and IIA cervical carcinomas: Ten-year treatment results of RTOG 79-20. JAMA 274 (1995) 387-393
29. Rotman M., Choi K., Guse C., et al. Prophylactic irradiation of the para-aortic lymph node chain in stage IIB and bulky stage IB carcinoma of the cervix, initial treatment results of RTOG 7920. Int J Radiat Oncol Biol Phys 19 (1990) 513-521
30. Haie C., Pejovic M.H., Gerbaulet A., et al. Is prophylactic para-aortic irradiation worthwhile in the treatment of advanced cervical carcinoma? Results of a controlled clinical trial of the EORTC radiotherapy group. Radiother Oncol 11 (1988) 101-112