LPS-stimulated apert syndrome gingival keratinocytes snow markedly suppressed inflammatory cytokine production

Journal of Oral Biosciences

Volumn 50, Issue 1, 2008, Pages 59-67

  Kurata, Kazuyuki ^a   Ara, Toshiaki ^a   Kurihara, Saburo ^a   Yamada, Kazuhiro ^a   Wang, Pao Li ^a  

^a MATSUMOTO DENTAL UNIVERSITY   (Japan)

Author keywords

Apert syndrome; Inflammatory cytokines; Keratinocyte; LPS; Matrix metalloproteinase

Indexed keywords

EID: 40949138530     PISSN: 13490079     EISSN: None     Source Type: Journal    
DOI: 10.2330/joralbiosci.50.59     Document Type: Article

References (25)

1. Cohen, M. M. Jr, Kreiborg, S., Lammer, E. J., Cordero, J. F., Mastroiacovo, P., Erickson, J. D., Roeper, P. and Martinez Frias, M. L. : Birth prevalence study of the Apert syndrome. Am. J. Med. Genet. 42: 655-659, 1992.
2. Wilkie, A. O., Slaney, S. F., Oldridge, M., Poole, M. D., Ashworth, G. J., Hockley, A.D., Hayward, R. D., David, D. J., Pulleyn, L. J., Rutland, P., Malcolm, S., Winter, R. M. and Reardon, W : Apert syndrome results from localized mutations of FGFR2 and is allelic with Crouzon syndrome. Nat. Genet. 9: 165-172, 1995.
3. Miki, T., Bottaro, D. P., Fleming, T. P., Smith, C. L., Burgess, W. H., Chan, A. M. and Aaronson, S. A. : Determination of ligand-binding specificity by alternative splicing : two distinct growth factor receptors encoded by a single gene. Proc. Natl. Acad. Sci. USA 89: 246-250, 1992.
4. Ornitz, D. M., Xu, J., Colvin, J. S., McEwen, D. G., MacArthur, C. A., Coulier, F., Gao, G. and Goldfarb, M. : Receptor specificity of the fibroblast growth factor family. J. Biol. Chem. 271: 15292-15297, 1996.
5. Orr-Urtreger, A., Givol, D., Yayon, A., Yarden, Y. and Lonai, P : Developmental expression of two murine fibroblast growth factor receptors, flg and bek. Development 113: 1419-1434, 1991.
6. Shi, D. L., Launay, C., Fromentoux, V., Feige, J. J. and Boucaut, J. C. : Expression of fibroblast growth factor receptor-2 splice variants is developmentally and tissue-specifically regulated in the amphibian embryo. Dev. Biol. 164: 173-182, 1994.
7. Igarashi, M., Finch, P. W. and Aaronson, S. A. : Characterization of recombinant human fibroblast growth factor (FGF) - 10 reveals functional similarities with keratinocyte growth factor (FGF-7). J. Biol. Chem. 273: 13230-13235, 1998.
8. Anderson, J., Burns, H. D., Enriquez-Harris, P., Wilkie, A. O. and Heath, J. K. : Apert syndrome mutations in fibroblast growth factor receptor 2 exhibit increased affinity for FGF ligand. Hum. Mol. Genet. 7: 1475-1483, 1998.
9. Yu, K., Herr, A. B., Waksman, G. and Ornitz, D. M. : Loss of fibroblast growth factor receptor 2 ligand-binding specificity in Apert syndrome. Proc. Natl. Acad. Sci. USA 97: 14536-14541, 2000.
10. Ibrahimi, O. A., Eliseenkova, A. V., Plotnikov, A. N., Yu, K., Ornitz, D. M. and Mohammadi, M. : Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome. Proc. Natl. Acad. Sci. USA 98: 7182-7187, 2001.
11. Mansukhani, A., Bellosta, P., Sahni, M. and Basilico, C.: Signaling by fibroblast growth factors (FGF) and fibroblast growth factor receptor 2 (FGFR2) -activating mutations blocks mineralization and induces apoptosis in osteoblasts. J. Cell Biol. 149: 1297-1308, 2000.
12. Lemonnier, J., Haä, E., Delannoy, P., Fromigué, O., Lomri, A., Modrowski, D. and Marie, P. J. : Increased osteoblast apoptosis in apert craniosynostosis : role of protein kinase C and interleukin - 1. Am. J. Pathol. 158: 1833-1842, 2001.
13. Tanimoto, Y., Yokozeki, M., Hiura, K., Matsumoto, K., Nakanishi, H., Matsumoto, T., Marie, P. J. and Moriyama, K. : A soluble form of fibroblast growth factor receptor 2 (FGFR2) with S252W mutation acts as an efficient inhibitor for the enhanced osteoblastic differentiation caused by FGFR2 activation in Apert syndrome. J. Biol. Chem. 279: 45926-45934, 2004.
14. Baroni, T., Carinci, P., Lilli, C., Bellucci, C., Aisa, M. C., Scapoli, L., Volinia, S., Carinci, F., Pezzetti, F., Calvitti, M., Farina, A., Conte, C. and Bodo, M. : P253R fibroblast growth factor receptor-2 mutation induces RUNX2 transcript variants and calvarial osteoblast differentiation. J. Cell Physiol. 202: 524-535, 2005.
15. Kaloust, S., Ishii, K. and Vargervik, K. : Dental development in Apert syndrome, Cleft. Palate Craniofac. J. 34: 117-121, 1997.
16. Mustafa, D., Lucas, V. S., Junod, P., Evans, R., Mason, C. and Roberts, G.J. : The dental health and caries-related microflora in children with craniosynostosis. Cleft. Palate Craniofac. J. 38: 629-635, 2001.
17. So, F., Daley, T. D., Jackson, L. and Wysocki, G. P.: Immunohistochemical localization of fibroblast growth factors FGF-1 and FGF-2, and receptors FGFR2 and FGFR3 in the epithelium of human odontogenic cysts and tumors. J. Oral Pathol. Med. 30: 428-433, 2001.
18. Wakulich, C., Jackson-Boeters, L., Daley, T. D. and Wysocki, G. P. : Immunohistochemical localization of growth factors fibroblast growth factor-1 and fibro-blast growth factor-2 and receptors fibroblast growth factor receptor-2 and fibroblast growth factor receptor-3 in normal oral epithelium, epithelial dysplasias, and squamous cell carcinoma. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 93: 573-579, 2002.
19. Ropiquet, F., Huguenin, S., Villette, J. M., Ronfle, V., Le Brun, G., Maitland, N. J., Cussenot, O., Fiet, J. and Berthon, P. : FGF7/KGF triggers cell transformation and invasion on immortalised human prostatic epithelial PNT1A cells. Int. J. Cancer 82: 237-243, 1999.
20. Slaney, S. F., Oldridge, M., Hurst, J. A., Moriss-Kay, G. M., Hall, C. M., Poole, M. D. and Wilkie, A. O. : Differential effects of FGFR2 mutations on syndactyly and cleft palate in Apert syndrome. Am. J. Hum. Genet. 58: 923-932, 1996.
21. Heussen, C. and Dowdle, E. B. : Electrophoretic analysis of plasminogen activators in polyacrylamide gels containing sodium dodecyl sulfate and copolymerized substrates. Anal. Biochem. 102: 196-202, 1980.
22. Portnoy, J., Curran-Everett, D. and Mason, R.J.: Keratinocyte growth factor stimulates alveolar type II cell proliferation through the extracellular signal-regulated kinase and phosphatidylinositol 3-OH kinase pathways. Am. J. Respir. Cell Mol. Biol. 30: 901-907, 2004.
23. Bartold, P. M. and Haynes, D. R. : Interleukin-6 production by human gingival fibroblasts. J. Periodontal Res. 26: 339-345, 1991.
24. Takada, H., Mihara, J., Morisaki, I. and Hamada, S. : Induction of interleukin-1 and -6 in human gingival fibroblast cultures stimulated with Bacteroides lipopolysaccharides. Infect. Immun. 59: 295-301, 1991.
25. Okada, H. and Murakami, S. : Cytokine expression in periodontal health and disease. Crit. Rev. Oral Biol. Med. 9: 248-266, 1998.